Protein Alignment MAST2 and gwl

DIOPT Version :9

• Sequence 1: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_524860.2
• Gene: gwl / 45969
• FlyBaseID: FBgn0260399
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 800
• Identity: 143/800 - (17%)
• Similarity: 213/800 - (26%)
• Gaps: 479/800 - (59%)

Human   567 EGHGASLPSKKTPSEEDFETIKLISNGAYGAVFL-VRHKSTRQRFAMKKINKQNLILRNQIQQAF 630
            |.|.   .:.|.|:.:||..||.||.||:|.||| .::..:::.||:|.:.|..:|.:|.:.|..
  Fly    43 ENHS---QNAKLPTIKDFVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVI 104

Human   631 VERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLAL 695
            .||:.|..:.:.|.||:|.|..:..::.:||||:.|||..:||...|.......|.|.||.|:||
  Fly   105 TERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMAL 169

Human   696 EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIG------------------------LMSL 736
            :|||.:||||||:||||:|::|.||:||||||||||.                        |:||
  Fly   170 QYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSL 234

Human   737 TTNLYEG---------------------------------------------------------- 743
            |::|..|
  Fly   235 TSHLSFGSEKKLNDFGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTS 299

Human   744 ----------------------------------------------------------------- 743
                                                                             
  Fly   300 DSKISGVSPFFSAEEANESITHTCTTNVNPQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNA 364

Human   744 -----------------------------------HIEK-------------------DAR---- 750
                                               |:.|                   |.|
  Fly   365 IPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRIS 429

Human   751 ----------------------------------------------------------------- 750
                                                                             
  Fly   430 KGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSG 494

Human   751 -----------------EFL--------------------------------------------- 753
                             :||
  Fly   495 INMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNGSTNTGLTQEIEILNIG 559

Human   754 ----------------------------------------------------------------- 753
                                                                             
  Fly   560 SSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKL 624

Human   754 ----------------------------------------------------------------- 753
                                                                             
  Fly   625 KATRFALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTP 689

Human   754 ----------DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQ 808
                      ::::.|||:|:|||::|:||:|..|||||:|:..|||:.|..||..:||:::|..
  Fly   690 KSVRRGARVSNERILGTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDN 754

Human   809 VISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 873
            :::..|.||||||||..::.:....||..:|.||   .:|.||:|...|..:||..:...:..|:
  Fly   755 ILNKNIEWPEGDEALSVESMEAVELLLTMDPNER---PAAKEVQQMRHFACIDWENIGNTEPPFV 816

Human   874 PQLESEDDTSYFDTRSERYH 893
            |..::..||.|||.|:...|
  Fly   817 PTPDNPTDTGYFDARNNLQH 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070
		STKc_MAST	583..862	CDD:270760	128/751 (17%)
		S_TKc	584..857	CDD:214567	126/745 (17%)
		PDZ_signaling	1177..1258	CDD:238492
gwl	NP_524860.2	STKc_MASTL	52..>255	CDD:270761	78/202 (39%)
		S_TKc	57..>205	CDD:214567	68/147 (46%)
		PKc_like	<655..835	CDD:304357	55/182 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900