DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST2 and dop

DIOPT Version :9

Sequence 1:	XP_011539361.1	Gene:	MAST2 / 23139	HGNCID:	19035	Length:	1870	Species:	Homo sapiens
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	2098	Identity:	753/2098 - (35%)
Similarity:	994/2098 - (47%)	Gaps:	605/2098 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    81 STGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSS-----VGQVTWQS--------SG 132
            ||....:.|.|          ||..|.|| .|...|||:||.     :.::::|.        ||
  Fly   168 STNGSSMMRNL----------NLTKSSSG-GLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSG 221

Human   133 EASNLVRMRNQSLGQSAPSLTAGL--KELSLPRRGSLISTLCRGAEVNQHMFSPTSAPALFLT-- 193
            |.|||:|||:.|||:|||.||...  .||:.|                    .|...|....:
  Fly   222 ETSNLLRMRHSSLGKSAPCLTGNYFRHELTAP--------------------LPVQPPGFGASPL 266

Human   194 ---KVPFSADCALATSPLAIFLNPRAH----------SSPGTPCSSRPLPWSCRTSNRKSLIVTS 245
               .:..|..||      .|.|....|          .|.|....|.....|....:|.||:..|
  Fly   267 GGHNISRSGSCA------GIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNS 325

Human   246 STSPTL--PRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVP-ARSHSHRADRTDGRRWSLASLP 307
            :.....  .|.|||...    ||:||||   .|:|..|:|.| .|..|.|....||||||:||||
  Fly   326 AAVAAAGGSRTHSPYSA----SPVDSPR---LNSPMPFAFAPIKRIASCRGVVADGRRWSVASLP 383

Human   308 SSGYGTNTPSSTVSSSCSSQEKLHQL--------------------------------------- 333
            ||||||...||.:||.|||||.|:||
  Fly   384 SSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLA 448

Human   334 ---------PFQPT---------------ADELHFL---------------TKHFSTESVPDEEG 359
                     |.:||               ..||...               :.:.|..|.....|
  Fly   449 VSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGG 513

Human   360 RQSPAMRPRSRSL-SPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLA 423
            |.||..||||||| ||.|||: .|:||.:||.:|||||||||.||||||..||:.|...:.....
  Fly   514 RMSPYFRPRSRSLSSPSRSPI-VDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFR 577

Human   424 DG--ALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVK 486
            |.  .:.|:||||:|||||||.||.:.||||||||||.:|||:||.:..|:|..: .|.:..::|
  Fly   578 DSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKSPEA-AAELNGVIK 641

Human   487 KLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEM--- 548
            ||::||:|||||||||||||:|||.||||||||||....||.|||:||:.:|||.|||:.|:
  Fly   642 KLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQE 706

Human   549 -----------------------------------AQLSS-------CDS----------PDTP- 560
                                               .||||       .||          |.||
  Fly   707 LRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPV 771

Human   561 ---ETDDSI----------------------------------------EGHGASLPSKKTPSEE 582
               :|..|.                                        .|.||..||   |.|.
  Fly   772 ATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGSGAQQPS---PQEN 833

Human   583 DFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM 647
            ||:.:|||||||||||:||:||:||||||||||||.|||||||::|.|.|||||:||:|||||||
  Fly   834 DFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSM 898

Human   648 FCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDN 712
            :|||:||:|||:||||||||||.|||||||.||.||.|.||||||||:||||:||||||||||||
  Fly   899 YCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDN 963

Human   713 LLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKP 777
            ||||::||||||||||||:|||||.||||||:|:.:.|:|.||||.|||||||||||||||||||
  Fly   964 LLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKP 1028

Human   778 VDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDE-ALPPDAQDLTSKLLHQNPLE 841
            ||||:|||||||||:|||||||:|.||||...::|:|.||:.:: .:..:|:|:.|:||.|||.:
  Fly  1029 VDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRD 1093

Human   842 RLGTGS-AYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHH----MDSEDEE 901
            ||||.| |.|:|:|.:|.|:||..||||||||:|||..:|||||||||.:||:|    .|::|.:
  Fly  1094 RLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDTD 1158

Human   902 EVSEDGCLEIRQFSSCSPRFNKVYSSMER-----------------LSLLEER--RTP------- 940
            :....|     .|:|.:|::.|.:.|..|                 ||.|..|  .||
  Fly  1159 DTPVFG-----SFNSYTPQYRKQHYSWSRHATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGAT 1218

Human   941 -----PPTKRSLSEEKEDHSDGLAGLKGRDR--SWVIGSPEILRKRLSVSES-----SHTESD-- 991
                 |..|..:.......|...:|....|.  :..:.:|::  ::|.:|.|     |..::|
  Fly  1219 STGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQL--RKLDLSSSCLKVPSTPDADYL 1281

Human   992 -------------------------------------SSPPMTVRRRCSGLLDAPRFPEGPEEAS 1019
                                                 |.||.|     :.::..|..|. |.:..
  Fly  1282 PELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNT-----TTIISTPATPP-PTQTQ 1340

Human  1020 STLRRQPQE----GIWVLTPPSGEGVSGPVTEHSGEQR---------PK----LDEEAVGRSSGS 1067
            :|:...|..    .....||.|.:..|...:.....:|         |:    :::|.:...|.|
  Fly  1341 ATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSS 1405

Human  1068 SPAMETRGRGTSQLA--------EGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSAS 1124
            :..|.. .|..|.||        :|:|                 ||.|.:...:|   .::||||
  Fly  1406 TENMNL-PREQSPLALQHQPKSMDGST-----------------SGSSVKHHRSR---SIVKSAS 1449

Human  1125 ATALSLLIPSEH-----HTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGK 1184
            |..|||:...::     ..|. :.||....:.||..||||:||.|:..|.:.:::|||||.|..:
  Fly  1450 ALGLSLMTSLDNSQLAAQLCG-IQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGPR 1513

Human  1185 KYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELI 1249
            .:|||:..||||.||:|.||:||:|..|::|.||.|||||..|||||||||.|.||.||:|::|:
  Fly  1514 GFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLL 1578

Human  1250 LKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRS---KRSRGKDGQESRKRSSLFRKITKQA 1311
            |..|..|.:..||||:|||:.|..::...::|:|::.   ::.:.|...:.::::||||:|
  Fly  1579 LSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRI---- 1639

Human  1312 SLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSV 1376
                :|:..::..:..|:|.|.|.:|: :.:|||..  ..|.  .....|...:||||:|||||.
  Fly  1640 ----SSKRANAEMQQYSAGTSSPTTPS-ARNLSPLD--SSYH--SSCCQSAANSSSQSTSPSSSS 1695

Human  1377 PSSPAGSG--------------------------------------------------------- 1384
            |::|.||.
  Fly  1696 PNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTG 1760

Human  1385 -----HTRPSSLHGLAPKLQR---------QYRSP-----------------RRKSAGSIPLSPL 1418
                 :.|||:||||..||..         ...:|                 ||||.|.||||||
  Fly  1761 VVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPL 1825

Human  1419 AHTPSPPPPTASPQRSPSPLS----GHVAQAFPTKLHLSPPLGRQL----------------SRP 1463
            |.||||.|..:||.||||||:    ||...|..|....||  |..|                :|.
  Fly  1826 ARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSYSP--GSTLPTLQTAVNANTKKAGFART 1888

Human  1464 KSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGA-- 1526
            |||| |.||||:|..|.::|..  .::|.|:            |.|....|.::.:...||..
  Fly  1889 KSAE-PSSPLLRRALSPDRLHP--RSAETKI------------SPLCCSPPIKQPTHQRVVTTTW 1938

Human  1527 RSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQ 1591
            ||...|..:..|..|| .|||  :..|:...|...|| |:|.|:..|.|:   |..|.:.|..|
  Fly  1939 RSTPGGSASGAGGAVL-GAPS--VQPLQLVPAASEES-QRQTAMATVVST---TAAGTDPSATA- 1995

Human  1592 ELSLA---PHPEVSQSVAPKGAGESGEEDPFPSRDPRSLG----PMVPSLLTGITLGPPRMESPS 1649
            .::||   |.|.:::.          ::.|..::|..|:.    |.:.....|        ||.|
  Fly  1996 VVTLANCEPLPRIAEE----------KDSPTSTQDSSSVSEGFMPAIEEFAEG--------ESSS 2042

Human  1650 GPHRRLGSPQAIE--EAASSSSAGPN--LGQSGATDPIPPE------GCWKAQHLHTQALTALSP 1704
            .|.:.|..|..::  |......||.:  :.|...|.|..|:      ||       ..::|...|
  Fly  2043 SPTQTLEKPTKVKATEQPEMEPAGKSKKVDQGKTTTPGTPKTKPHNSGC-------KTSMTTTKP 2100

Human  1705 STSGLTPTSSCSPPSSTS 1722
            ::..:  |.|.:|...||
  Fly  2101 ASPSV--TISTAPRKDTS 2116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	164/362 (45%)
		STKc_MAST	583..862	CDD:270760	207/280 (74%)
		S_TKc	584..857	CDD:214567	204/274 (74%)
		PDZ_signaling	1177..1258	CDD:238492	47/80 (59%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	164/362 (45%)
		STKc_MAST	834..1115	CDD:270760	207/280 (74%)
		S_TKc	835..1110	CDD:214567	204/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	47/80 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154015
Domainoid	1	1.000	441	1.000	Domainoid score	I548
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	982	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm41421
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760