DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST2 and cek1

DIOPT Version :9

Sequence 1:	XP_011539361.1	Gene:	MAST2 / 23139	HGNCID:	19035	Length:	1870	Species:	Homo sapiens
Sequence 2:	NP_588310.1	Gene:	cek1 / 2539208	PomBaseID:	SPCC1450.11c	Length:	1338	Species:	Schizosaccharomyces pombe

Alignment Length:	1018	Identity:	249/1018 - (24%)
Similarity:	382/1018 - (37%)	Gaps:	332/1018 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   371 SLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLAD----------- 424
            ::.|.:..|:||.  :....|...|..|||.:::......  .|...:|:.|.:
pombe   316 TIPPVKIIVNFDK--VDSLRVQSPRSEKATIELDNYNPSL--ENCSSAVIALWEDIKTAVDTKIT 376

Human   425 GALSF-------------IHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLL------QDAH 470
            |.|..             |.|.|.|:..|.:    |.|:|:.....| .:||..|      .||.
pombe   377 GVLRLRNAIYYSERIRLEIDHHVQEIIDDVV----SNLVTNHSSTSL-GHLESKLAPSITFPDAC 436

Human   471 ERSESSEVAFVMQLVKKLMIIIARPA---------RLLECLEFDPEEFY--HLLEAAEG------ 518
            :..|:.|             .|.||.         |.|:..:......|  ||...:..
pombe   437 DALEAEE-------------CITRPGSATNTPQSDRSLDINDLSRSSSYSRHLSHVSLSNPDFAI 488

Human   519 ---------------HAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSS-----CDSPDTPETD 563
                           |.::........||:         |.|:.::..||     .|.|:.|.::
pombe   489 GSPMSQDSSNYSSPLHRRKASDSNFSDPRF---------DDLKYLSPNSSPRFVASDGPNRPASN 544

Human   564 -----------DSIEGHGASLPS-------------KKTPSEEDFETIKLISNGAYGAVFLVRHK 604
                       .::...|..|||             .:.||..|::.:|.||.||:|:|:|.:.:
pombe   545 GRSSLFSRGRASNLGDVGLRLPSPSPRIHTIVPNSAPEHPSINDYKILKPISKGAFGSVYLAQKR 609

Human   605 STRQRFAMKKINKQNLILRNQIQQAFVERDIL-TFAENPFVVSMFCSFDTKRHLCMVMEYVEGGD 668
            :|...||:|.:.|.|:|.:||:.....||.|| :..|:|||..::.:|.:|.:|.:||||:.|||
pombe   610 TTGDYFAIKILKKSNMIAKNQVINVRAERAILMSQGESPFVAKLYYTFQSKDYLYLVMEYLNGGD 674

Human   669 CATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGL 733
            |.:|||.:|.|.:|.:|.|.|||||.|..||:.||:|||:||:||||:..||:||||||||::|.
pombe   675 CGSLLKTMGVLDLDWIRTYIAETVLCLGDLHDRGIIHRDIKPENLLISQNGHLKLTDFGLSRVGY 739

Human   734 M--------------------------SLTT---------------------------------- 738
            |                          ||:|
pombe   740 MKRHRRKQSSSIPVLDLRDRSSAISDLSLSTASSVLEAQSLITPERPKRPSLNEKLLSLDGTSIR 804

Human   739 -----------------------------NLYEGHIEKDAREFLD-----KQVCGTPEYIAPEVI 769
                                         |::........:.|.:     |:..|||:|||||||
pombe   805 LAGQSFNYENSAEDSPTATNTPTSQVDESNIFRSTDSPRVQPFFENKDPSKRFIGTPDYIAPEVI 869

Human   770 LRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWP------EGDEALPPDAQ 828
            |.....|..|||::|.:::|||.|..||..:||:::|..:::..|.||      |...||
pombe   870 LGNPGIKASDWWSLGCVVFEFLFGYPPFNAETPDQVFQNILARRINWPAEVFTAESSVAL----- 929

Human   829 DLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYH 893
            ||..:||..||..|||.....|:|.||||..::|..:|.:...|:|:..|.:||.|||:|.
pombe   930 DLIDRLLCMNPANRLGANGVEEIKAHPFFKSVNWDTILEEDPPFVPKPFSPEDTVYFDSRG---- 990

Human   894 HMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYS--SMERLSLLEERRTPPPTKRSLSEEKEDHSD 956
                             ::.|.     |::.|:  ::.....|||.|......:.:|..:
pombe   991 -----------------LKGFD-----FSEYYNQPTVTEAQKLEEERPASSIPQHVSGNR----- 1028

Human   957 GLAGLKGRDRSWVIGSPEI---------------------LRKRLSVSESSHTE----------- 989
                 |||.||..|.:||.                     |||.....:|:.|.
pombe  1029 -----KGRLRSNTISTPEFGSFTYRNLDFLNKANRNTIQKLRKEHMAVKSAKTSVDDTFSQYMSR 1088

Human   990 -------SDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTE 1047
                   |.|..|:...||.| :.|        .|||:|.|.|.      :|..|.:.:....:.
pombe  1089 FKAKLSTSQSVGPVKSSRRAS-MAD--------YEASTTTRVQD------ITTDSIDSIDDFDSL 1138

Human  1048 HSGEQRPKLDEEAVGRSSGSSPAMETRGRGTS------QLAEGATAKAISDLAVRRARHRLLSGD 1106
            ..|......|..|:....|.|..|......:|      .:.||.::.  ....:::.|...|...
pombe  1139 KEGRMLSFFDNLALEDHKGVSSTMSASQSQSSMHTALPDVTEGTSSD--EHTTIQKGRIDNLQAQ 1201

Human  1107 S-TEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSP 1148
            | |.||.|.....:.:   ...|.::||.:....:.:...:.|
pombe  1202 SLTHKRNAISYPGLFQ---LDRLQMIIPKDEIELAEILKKIFP 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	43/237 (18%)
		STKc_MAST	583..862	CDD:270760	128/379 (34%)
		S_TKc	584..857	CDD:214567	125/373 (34%)
		PDZ_signaling	1177..1258	CDD:238492
cek1	NP_588310.1	S_TKc	589..958	CDD:214567	125/373 (34%)
		STKc_Rim15_like	592..964	CDD:270762	127/376 (34%)
		S_TK_X	959..1049	CDD:214529	27/125 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010