Protein Alignment MAST2 and kin-4

DIOPT Version :9

• Sequence 1: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_001255551.1
• Gene: kin-4 / 178068
• WormBaseID: WBGene00002192
• Length: 1831
• Species: Caenorhabditis elegans
• Alignment Length: 1781
• Identity: 634/1781 - (35%)
• Similarity: 866/1781 - (48%)
• Gaps: 400/1781 - (22%)

Human    13 PPPDRREDGVQRAAELSQSL----------------------------PPRRRAPPGRQRLEERT 49
            ||||||.......::.:.|:                            ||...:|       .|:
 Worm   126 PPPDRRTSFASTMSDTNSSITIPMSSSYQNLLSPMWSTMKYSSDDNETPPNEPSP-------RRS 183

Human    50 GPAGPEGKEQDVVTGVSPLLF--------RKLS-------------NPDIFSSTGK----VKLQR 89
            ..|.......|.: .|.|::|        |.:|             |.|..|.||.    |.|..
 Worm   184 KSALSNRSSSDCI-NVPPIVFSPVLSRPIRSMSPTMSMSPTFRTHHNSDSESDTGAQAAGVCLFA 247

Human    90 QLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRM----RNQSLG---- 146
            ..|.....:|:|      ||..::|...|.|...|.....||...||:.|:    |.:::.
 Worm   248 CTSSASGLVWKG------SGSLMIPPRRSFHRPQGGGGNDSSDSNSNVERLLKRNRRRTMAIHGV 306

Human   147 QSAPSLTAGLKELSLPRRGSLISTLCRGAEVNQH---MFSPTSAPALFLTKVPFSADCALATSPL 208
            ::.|..||.    |.....:.::.|||......|   ..|.:|..:...:..........:|:.|
 Worm   307 ETEPGQTAA----STGWTSASMTNLCRVRSSLGHSDPQLSSSSTNSFNTSTSSLHPATKSSTTAL 367

Human   209 AIFLNPRAHSSPGTPCSSRPLPWSCRTSNRKSLIVTSSTSP-TLPRPHSPLHGHTGNSPLDSPRN 272
            :.|....|:.||               :||.||  .||||| ||.|..||:  ........|..|
 Worm   368 SSFSTSSANRSP---------------ANRPSL--HSSTSPVTLQRCRSPM--RVPQRSTSSSHN 413

Human   273 F--------SPNAPAHFSFVP---ARSHSHR------ADRTDGRRWSLASLPS-SGYGT--NTPS 317
            |        |..:..|...:.   .|::|.|      |...|.|||||||||| |||||  ...:
 Worm   414 FGAAGAGPSSSGSSVHSGTITLSVCRTYSARNGSSLMAPVQDTRRWSLASLPSTSGYGTPGTGSN 478

Human   318 STVSSSCSSQEKLHQL--------PFQPTADELHFLTKHFSTESVPDEEGRQSPAM------RPR 368
            |.|||..||.|::.::        |.:..:      ::..|.:|..|....|..|.      |||
 Worm   479 SGVSSQYSSSEQIGEMLDQTRISGPVRQNS------SRFDSNDSYDDMASHQQAAAQNAFLNRPR 537

Human   369 SRSLSPGRSPVSFDSE--IIMMNH--VYKERFPKATAQMEERLAEFISSNTP------------- 416
            ||||:   ||:.|.:|  |.|:|.  |||||||:|..||||||..|::.|.|
 Worm   538 SRSLT---SPMKFLNEYNIEMVNRTSVYKERFPRAKLQMEERLNAFVAENGPLSGGISQQSARDD 599

Human   417 ---------------------DSVLP------------------------LADGALSFIHHQVIE 436
                                 |||..                        :.|||..|:|||::|
 Worm   600 TDRVDDLSARQSGSSSGLKAKDSVEEAVMRSRRSTVLEAESYADRSLLRLIGDGATRFLHHQIVE 664

Human   437 MARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLEC 501
            :|.|||.||:..|||..||.|:...||:.|.:|..::....:.::.:|||||::|::||||||||
 Worm   665 IALDCLGKSKDDLITCSYFCEMSQRLEETLNEAQMKTSPESLEYLSKLVKKLLMIVSRPARLLEC 729

Human   502 LEFDPEEFYHLLEAAEGHAKE--GQGIK--CDIPRYIVSQLGLTRDPLEEMAQL--SSCDSPDTP 560
            |||||:|||||||.|||..:|  |.|..  .|:|:||:.:|||.||||.:..:.  ||.::..|.
 Worm   730 LEFDPDEFYHLLEEAEGVVREQLGSGTARVPDLPQYIIGKLGLDRDPLIDSTEHVDSSENTHATT 794

Human   561 ETDDSIEGHGAS-LPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRN 624
            ....|.:|.|:: ..:.:.|.|:||:||:|:||||||||:||||:.||||||:||:|||.|:|||
 Worm   795 SGTTSAKGAGSAWQETNRAPCEDDFDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRN 859

Human   625 QIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFA 689
            |:.|.|.||||||.|:||||||.:.||:|:::|||:||||||||||.|||:.|.|||::||||.|
 Worm   860 QVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVELVRLYVA 924

Human   690 ETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDA----R 750
            ||:||:||||:||||||||||||||||:|||||||||||||||||:.||.:.||:   ||    :
 Worm   925 ETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGY---DAVVETQ 986

Human   751 EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIV 815
            :|.|||:||||||||||||||:||||||||||:||||||||||.|||||:|||.||.:|||:::.
 Worm   987 QFQDKQLCGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVE 1051

Human   816 WPEGDEALPPDAQDLTSKLLHQNPLERLGT-GSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESE 879
            :||.||||||:|.||..:||.:||.||||| ..|.::..|.||..||:|.||||||||:|||::|
 Worm  1052 YPEEDEALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFFILLDFTSLLRQKAEFVPQLDNE 1116

Human   880 DDTSYFDTRSERYHH-MDSEDEEEV---SEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTP 940
            :||||||||::||:| .:|..|||:   |....:....||:.|||.:.|......|..|..
 Worm  1117 EDTSYFDTRTDRYNHEAESCGEEEIVGSSAASSMMFHSFSTASPRHSIVSIDPAHLPHLLS---- 1177

Human   941 PPTKRSLSEEKE-DHSDGLAGLKGR-----DRSWVIGS--PEI-------------LRKRLSVSE 984
              |..:.::|.| .||   ..:..|     :||:..|.  ||:             ||:|.|...
 Worm  1178 --TANAAAKEIERSHS---VSMSSRPETRPERSYSTGQAPPELFKVGDDNTSTAVNLRRRFSAQR 1237

Human   985 SSHTESDSSPPMTVRRRC--------SGLLDAPRFP--EGPEEASSTLR--RQPQEGIWVLTPPS 1037
              |..|.:|...|....|        ...:||...|  :.|..:|...|  |.|.....:    |
 Worm  1238 --HNVSTTSSSGTGSGTCFATAASSTDSSIDASSLPLFQPPSRSSIAERGSRSPLPKFSI----S 1296

Human  1038 GEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRL 1102
            .||.:|  ...||:....||:      |.:|..:.|...|      ||      |..||..|
 Worm  1297 CEGEAG--VSRSGDDHDDLDD------SRNSTIVSTASSG------GA------DETVRFRR--- 1338

Human  1103 LSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTC---------SPLASPMSP--HSQSSNPS 1156
               .|:.:..|..:..||.|.|::..|........||         :.:.|.:||  .|.||..|
 Worm  1339 ---QSSGRTPASQLQLVIPSISSSQSSQSAEPARETCYVMYPSGPSTSVGSQLSPGGASVSSASS 1400

Human  1157 SRD-SSP------------SRDFLPALGSMRP--PIIIHRAGKKYGFTLRAIRVYMGD-SDVYTV 1205
            |.| .||            |.|...|..|..|  .|.|.:....:||||:::|||:|: |:.||:
 Worm  1401 SNDVGSPHPLPLHHEHPLTSHDSSAASSSTAPSKTITIRKGPFGFGFTLKSVRVYLGEHSEYYTI 1465

Human  1206 HHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKV 1270
            .|:|..|.:|.||..|.|:..|:||||||.|||.|.|.:::..:|.:||::.:...||.||||:.
 Worm  1466 EHIVTAVVEGSPAFHANLQAEDMITHVNGHPVHNLTHPQLMHRLLANGNELILRLVPLANTSIRE 1530

Human  1271 GPARK--GSYKAKMARRSKRSRGKDGQESRKRSSLFRKIT---------------KQASLLHTSR 1318
            |.||:  |....|..:|.:|......:::||.|:|.|:::               |||.:   .|
 Worm  1531 GAARRTVGKMARKKPKRPQRRVVPLEKKTRKPSALLRRLSGKRATNDIVPGSSSQKQAFM---PR 1592

Human  1319 SLSSLN----------RSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSP- 1372
            |.||.:          ..:|..|:.....|.|..:..||..:.....|.::.|...:......|
 Worm  1593 SASSQDGCILTHLPGTSKISQQEASQEPSTSSQGMVRRSVNEIETNRPSSLRSTSNSHHHHHHPA 1657

Human  1373 -SSSVPSSPAGSGHTRPSSLHGLAPKLQRQ------YRSPRRKSAG---------SIPLSPLAHT 1421
             :|||.|:||....|.||:|..:|......      ..||...|:|         ||.:||||..
 Worm  1658 STSSVASAPATLPSTTPSNLSRMASSSPSSSASNSGTSSPAATSSGISIVKQKSQSIAVSPLARD 1722

Human  1422 PSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRP-------KSAEPPRSPLLKRVQS 1479
                    :..||||          |:.||..|......:||       .|:.|..|..::.:.|
 Worm  1723 --------TRMRSPS----------PSHLHHRPASSSYTTRPDGVVTPATSSSPNNSGFVQDLIS 1769

Human  1480 AEKLAAALAASEKKLATSRKHSLDLP 1505
            :.: :..|:|..:....:...|:.:|
 Worm  1770 SRQ-SPNLSARRRSYQPTTTTSMIVP 1794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	139/380 (37%)
		STKc_MAST	583..862	CDD:270760	199/283 (70%)
		S_TKc	584..857	CDD:214567	195/277 (70%)
		PDZ_signaling	1177..1258	CDD:238492	36/81 (44%)
kin-4	NP_001255551.1	DUF1908	455..779	CDD:286070	130/332 (39%)
		STKc_MAST	818..1099	CDD:270760	199/283 (70%)
		S_TKc	819..1094	CDD:214567	195/277 (70%)
		PDZ_signaling	1434..1521	CDD:238492	36/86 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161462414
Domainoid	1	1.000	404	1.000	Domainoid score	I400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	800	1.000	Inparanoid score	I268
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm15440
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980