DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST2 and mast2

DIOPT Version :9

Sequence 1:	XP_011539361.1	Gene:	MAST2 / 23139	HGNCID:	19035	Length:	1870	Species:	Homo sapiens
Sequence 2:	XP_009300769.1	Gene:	mast2 / 100001267	ZFINID:	ZDB-GENE-050309-150	Length:	1934	Species:	Danio rerio

Alignment Length:	1979	Identity:	1243/1979 - (62%)
Similarity:	1404/1979 - (70%)	Gaps:	281/1979 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    55 EGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSV 119
            |||::: :....|||||||||||:..:.||.||||||||||.:..|.::|..|:||||||||||:
Zfish    23 EGKDEE-LPAPPPLLFRKLSNPDLSPAAGKTKLQRQLSQDDSRGRRSSMAGILTGKQLLPLSSSM 86

Human   120 HSSVGQVTWQS-SGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSLISTLCRGAEVNQHMFS 183
            |..|.|:.||. :||.:||||||:||.|||||||||||||||||||||.
Zfish    87 HGGVSQLAWQQHTGEPNNLVRMRSQSFGQSAPSLTAGLKELSLPRRGSF---------------- 135

Human   184 PTSAPALFLTKVPFSADCALATSPLAIFLNPRAHSSPGTPCSSRPLPWSCRTSNRKSLIVTSSTS 248
                                                             ||||||||||||||||
Zfish   136 -------------------------------------------------CRTSNRKSLIVTSSTS 151

Human   249 PTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARSHSHRADRTDGRRWSLASLPSSGYGT 313
            |||||||||||||.|:||||||||||||..|||||||||||.|||||||||||||||||||||||
Zfish   152 PTLPRPHSPLHGHPGSSPLDSPRNFSPNTAAHFSFVPARSHGHRADRTDGRRWSLASLPSSGYGT 216

Human   314 NTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSP 378
            |||||||||||||||||||||||||||||||||||||:||:.||:||:|||||||||||||||||
Zfish   217 NTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSSESITDEDGRRSPAMRPRSRSLSPGRSP 281

Human   379 VSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLD 443
            :|||.||:||||||||||||||||||.|||:||||:.|:.|:|||||.||||||||||::|||||
Zfish   282 ISFDHEIVMMNHVYKERFPKATAQMEVRLADFISSSAPEKVMPLADGVLSFIHHQVIELSRDCLD 346

Human   444 KSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEE 508
            |||.|||||:||||||:|||||.|||||||||.||.||.||||||||||||||||||||||||||
Zfish   347 KSREGLITSRYFYELQENLEKLHQDAHERSESGEVTFVTQLVKKLMIIIARPARLLECLEFDPEE 411

Human   509 FYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETD-DSIEGHG 570
            |||||||||||||||||||.||||||:||||||||||||||||||.||  |:||||: ||.:..|
Zfish   412 FYHLLEAAEGHAKEGQGIKSDIPRYIISQLGLTRDPLEEMAQLSSYDSGNPETPETETDSTDSRG 476

Human   571 ASL----------PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQ 625
            |::          |..|||.||||||||||||||||||||||||.||||||||||||||||||||
Zfish   477 ATVQPLQPQPQPQPKTKTPREEDFETIKLISNGAYGAVFLVRHKETRQRFAMKKINKQNLILRNQ 541

Human   626 IQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAE 690
            ||||||||||||||||||||||||||:|:||||||||||||||||||||:||||||||.|:||||
Zfish   542 IQQAFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKHIGALPVDMARMYFAE 606

Human   691 TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDK 755
            ||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||.||||||
Zfish   607 TVLALEYLHNYGIVHRDLKPDNLLITSMGHVKLTDFGLSKIGLMSLTTNLYEGHIEKDTREFLDK 671

Human   756 QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGD 820
            |||||||||||||||||||||||||||||:|||||||||.|||||||||||||||||||:|||||
Zfish   672 QVCGTPEYIAPEVILRQGYGKPVDWWAMGVILYEFLVGCAPFFGDTPEELFGQVISDEIIWPEGD 736

Human   821 EALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYF 885
            ||||||||||.||||.||||||||||||:|||||.|||.|||..|||||||||||||||||||||
Zfish   737 EALPPDAQDLISKLLRQNPLERLGTGSAFEVKQHRFFTDLDWNSLLRQKAEFIPQLESEDDTSYF 801

Human   886 DTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEE 950
            ||||:||||:|||:|::.::|..|||||||||||||:|||||||||||.||:|||||||||||||
Zfish   802 DTRSDRYHHVDSEEEDDTNDDDHLEIRQFSSCSPRFSKVYSSMERLSLHEEKRTPPPTKRSLSEE 866

Human   951 KEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRR-CSGLLDAPRFPEG 1014
            ..:..|.|:|||.|||||::|||||||||||||||||||||||||:||||| ||.:::.|||...
Zfish   867 GGERIDSLSGLKSRDRSWLVGSPEILRKRLSVSESSHTESDSSPPLTVRRRCCSAIIEMPRFAIS 931

Human  1015 PEEASST-LRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSS---------- 1068
            .||.|.. .|:.|..|      |.|:.:...:.|...|:..:|||......|.||
Zfish   932 SEEDSCVGSRKTPVRG------PRGDDLPQAIPELPVERELRLDESPTTPGSTSSQISQSTLTPG 990

Human  1069 ---PAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSL 1130
               ..::...|.:::::|.:|.:||||||.||||||||||| |:|.|:||::|||||||||.|||
Zfish   991 SSGDVLDRASRYSAEVSENSTPRAISDLAARRARHRLLSGD-TDKHTSRPLSKVIKSASATTLSL 1054

Human  1131 LIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRV 1195
            :||::||..|||||||||||.||||||||||||||..||:.|::|.|||||||||||||||||||
Zfish  1055 MIPADHHGASPLASPMSPHSLSSNPSSRDSSPSRDLSPAVCSVKPAIIIHRAGKKYGFTLRAIRV 1119

Human  1196 YMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAIST 1260
            ||||:|:||||||||||||||||.|||||:||||||||||||||||||||||||||||:||:||.
Zfish  1120 YMGDTDIYTVHHMVWHVEDGGPAHEAGLREGDLITHVNGEPVHGLVHTEVVELILKSGSKVSISA 1184

Human  1261 TPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNR 1325
            ||.||||||||||||.|||:|||||:||::.::||:|:||:||||||||||:|||||||||||||
Zfish  1185 TPFENTSIKVGPARKTSYKSKMARRNKRTKTREGQDSKKRNSLFRKITKQATLLHTSRSLSSLNR 1249

Human  1326 SLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSS 1390
            |:|||||.||||||   :||||||||.|.|||:.||||||||||||||||||:|||.||..||||
Zfish  1250 SVSSGESVPGSPTH---MSPRSPTQGCRSTPDSAHSVGGNSSQSSSPSSSVPNSPASSGQIRPSS 1311

Human  1391 LHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGH------VAQAFPTK 1449
            |||||||||||||||||||||:|||||||.||||.|.:.|||||||||..|      :.|:||.|
Zfish  1312 LHGLAPKLQRQYRSPRRKSAGNIPLSPLARTPSPTPQSTSPQRSPSPLPSHGLITSSIGQSFPVK 1376

Human  1450 LHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAAL----------AASEKKL--ATSRKHSL 1502
            ||.||||.||:||||||:||||||||||||||||||:|          :|::|||  ..||||||
Zfish  1377 LHSSPPLVRQISRPKSADPPRSPLLKRVQSAEKLAASLSSSSSSPSPSSAADKKLPVGASRKHSL 1441

Human  1503 DLPHSELKKELPPREVS--PLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQD--------- 1556
            |..|||.|||:..|:.|  .|:...:.:::.|:.:...||.||.:..|.||  ||:
Zfish  1442 DTSHSEFKKEMLQRDPSLQSLQESASETLMGGRVSPAEKGSLQKSSVRKLG--RQEGPESGTGTL 1504

Human  1557 ----------------RAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSV 1605
                            |||||||||||:||.|||||||:|:||.|:||..:....||...|.:..
Zfish  1505 GLVPGKSKLKDKLSAIRAERRESLQKQDAIHEVDSSEDETDEGSEDSQDGRRTCYAPPSHVLRPT 1569

Human  1606 APKGAGESGEEDPFPSRDPRSLG--------PMVPSLLTGI------TLGPPRMESPSGPHRRLG 1656
            ....:..:....|   ..|.:||        |..|.|:.|:      |.......|.|.|.:...
Zfish  1570 TVMASPHTIRMGP---AAPPTLGLFPSTVAPPCSPQLIRGLQIQNQSTTQSQTQTSTSQPAQAAV 1631

Human  1657 SP---QAIEEAASSSSA--GPNLGQSGATD----PIPPEGCWKAQHLHTQ--ALTALS------P 1704
            .|   :.|.....|||.  ..:..||.|.|    |.|.:....:....||  |.|::|      |
Zfish  1632 KPPEQKPITSVKDSSSTIIDDSKKQSQAQDIQSRPSPHQPSPLSSTFSTQGSAFTSVSKDPFVKP 1696

Human  1705 STSGLTP--TSSCSPP-SSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLEN------ 1760
            :|..|.|  |...|.| |.|||:..    .|...|..|.:|.......|....:::.:|
Zfish  1697 TTPPLDPRRTPKMSEPRSKTSGRTD----SSTTSGVARDTPVATTPTGGITKEMKEADNRRQAAA 1757

Human  1761 ---------TTPAQ-----------------------------PKNLSPREQGKTQPPSAP---- 1783
                     ||.|.                             |......|:.|.|...|.
Zfish  1758 AAAASAAAATTSASTASESGMDKVVSQLATVAKSVLGPVKLNIPGTKETMERTKDQRTQADATHP 1822

Human  1784 -----RLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCPLTQKSEP- 1842
                 ||.||  :.|.|    .|..|.:..:.|.|  |:.|...             .:.||||
Zfish  1823 KIKECRLEHP--DSPDQ----LSPSAASGSQSPRL--TESPSKQ-------------TSSKSEPA 1866

Human  1843 --SLRRGQEPG-----------GHQKHRD 1858
              |.|..:.||           ..::|:|
Zfish  1867 STSQRPLEVPGTFKRQTSPIPQAREEHQD 1895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	250/280 (89%)
		STKc_MAST	583..862	CDD:270760	262/278 (94%)
		S_TKc	584..857	CDD:214567	257/272 (94%)
		PDZ_signaling	1177..1258	CDD:238492	75/80 (94%)
mast2	XP_009300769.1	DUF1908	169..450	CDD:286070	250/280 (89%)
		STKc_MAST	499..778	CDD:270760	262/278 (94%)
		S_TKc	500..773	CDD:214567	257/272 (94%)
		PDZ_signaling	1101..1182	CDD:238492	75/80 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341279
Domainoid	1	1.000	539	1.000	Domainoid score	I2258
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7428
Inparanoid	1	1.050	2238	1.000	Inparanoid score	I345
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43936
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm26781
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11433
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300