DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPB41L3 and cora

DIOPT Version :9

Sequence 1:NP_001371614.1 Gene:EPB41L3 / 23136 HGNCID:3380 Length:1105 Species:Homo sapiens
Sequence 2:NP_523791.2 Gene:cora / 37205 FlyBaseID:FBgn0010434 Length:1698 Species:Drosophila melanogaster


Alignment Length:1752 Identity:431/1752 - (24%)
Similarity:608/1752 - (34%) Gaps:803/1752 - (45%)


- Green bases have known domain annotations that are detailed below.


Human    90 KSSSSKLSRSPLKIVKKPKSMQ--------CKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLL 146
            |.|:.....:|.|  .||||..        .:|.|||||.....:::::.|:.:.:.:|..|||:
  Fly     6 KPSAPAEPETPTK--SKPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLI 68

Human   147 EKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRD 211
            |||||||||....:.:.|||..|.:.|..|:..|..:|.||||||:|:||.||||||:||||:|:
  Fly    69 EKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRN 133

Human   212 DIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGS-DYISEFRFAPNHTKELEDKVIELHKSHR 275
            ||:.|||||:|||.||||||.||||:||||.:|..: .|:.:|:.|||.|.||||||::|||:|:
  Fly   134 DILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHK 198

Human   276 GMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKI 340
            |.:|||||:|:|||||||:|||||||.|||||||:|||||||||||:|||:||||||||||:|||
  Fly   199 GQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKI 263

Human   341 SYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPE--APPKKFLTLG 403
            ||||::||||||||||||:||||||||.||||||:|||.||||||||||:.||  :..|.|...|
  Fly   264 SYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFG 328

Human   404 SKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLD----------------------- 445
            |.:||.|||||::  .:..:||..|.|.|:.|.....|||:|                       
  Fly   329 STYRYKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDR 391

Human   446 ----------------------------------------------------------------- 445
                                                                             
  Fly   392 NADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGA 456

Human   446 --GASVNENHEI--YMKDSMSAAEVGTGQYAT---------------------TKGISQTNLITT 485
              ||:||.|.|:  ..|...|:...|.|.:::                     .|.:.:..|:.|
  Fly   457 AAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVT 521

Human   486 -------------------------------------------VTPEKKAEE----ERDEEEDKR 503
                                                       .:|.:|:..    ..|::.:.|
  Fly   522 SGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSR 586

Human   504 RKG----EEVTPISAIRHEGKSPGLGTDSCP------------------------------LSP- 533
            :.|    |:::|.|    :.|..||..:..|                              ||| 
  Fly   587 KSGADGQEQLSPTS----QQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPK 647

Human   534 ------------PSTHC----------------------APT------------------SPT-- 544
                        |:|..                      :||                  .||  
  Fly   648 SRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTKGPQGYSSGAPGSYKPISDPTAD 712

Human   545 --ELRRRCKENDCKLPGY-EPSRAEHLPG-EPALDSDGPGRPYLGDQDVAFSYRQQTGKG----- 600
              |.:|..||     ||| .||:|:...| ..|..|..||.|            .:||||     
  Fly   713 FLESQRYNKE-----PGYVGPSKADVAAGLAGAAGSKKPGSP------------TKTGKGAPGAA 760

Human   601 ---------------------------TTLFSFSLQLPESFPSLLDDDGYLSFPNLSETNLLPQS 638
                                       |:.|.                     |:....:....|
  Fly   761 AAAAAGAAGAAAAAAKPKKRRVKIMVITSKFD---------------------PSTKRIDAENGS 804

Human   639 LQHYLPIRSPSLVPCFLFIFFFLLSASFSV--PYALTL--------------------SFPLALC 681
            ::|...|..|:.         .|:...:.|  |...||                    :..|.|.
  Fly   805 IEHSTGILDPAT---------GLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLV 860

Human   682 LCYLEPKAASLSASLDN----DPSDSSEEETD--SERTDTAADGETTATESDQEED--------- 731
            ....:||...|..:|..    .|.|:...|..  :.|.|.|. |:......|.|..         
  Fly   861 SGVADPKTGRLDDTLGQIVCITPQDNPVVELTVITSRIDPAT-GKIDTVNGDVERSLGVLNLDTG 924

Human   732 -------------AELKA----------------------------------------------- 736
                         .||||                                               
  Fly   925 LLDTKYGEINTRTGELKAIDPKSGKIVVSKNVKVDPGTGQITILGIVDPKTNKIDPNQGRLIEVG 989

Human   737 QELE---------------------KT----------------------QDDLMKHQTNISELK- 757
            |:::                     ||                      |.||:||....::.| 
  Fly   990 QQIDPIVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKS 1054

Human   758 -RTF-----LETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLVPEETK----QSSGEKLMD 812
             :|.     :|.:|...|........:..|.:..||.....:::..|...||    :.|..|..|
  Fly  1055 GKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLRIVQQRVDPATKAPITEVSASKDKD 1119

Human   813 ------GSEIF---SLLESARKPTEFIGGVTSTSQSWV-------------QKMETKTESSGIET 855
                  .::|:   ...:.|.|..::|.........:|             .|.:||.:.:.|:.
  Fly  1120 IVVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKI 1184

Human   856 EPTVHHLPLSTEKVVQET-------------------------------VLV--------EER-- 879
            |||...:..:|.:|.|.|                               |:|        :||  
  Fly  1185 EPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKLARVDPKTGKIVIVRILLISKTDERGR 1249

Human   880 ----------------------------------------------------------------- 879
                                                                             
  Fly  1250 PEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQVDPNDPRFAGARTTVTHTMTLTGE 1314

Human   880 ------RVVHASGDASYSAGDSGDAAA-------------------------------------- 900
                  |:....||...:.||...|.|                                      
  Fly  1315 IDPVTGRIKSEYGDIDPNTGDIDPATAVTDPVTGKLILNYAQIDPSHFGKQAQVQTTTETVPITR 1379

Human   901 QPAFTGIKGKEGSAL---TEGAKEE------GGEEV----------------------------- 927
            |..|.|:|.....||   :||:.::      |.::|                             
  Fly  1380 QQFFDGVKHISKGALRRDSEGSSDDDMTAQYGADQVNEILIGSPAGQAGGKLGKPVSTPTVVKTT 1444

Human   928 AKAVL-----------EQE-------ETAAASRERQEE------------------QSAAIH--- 953
            .|.||           |:|       |...:::|.:.:                  ::|..|   
  Fly  1445 TKQVLTKNIDGVTHNVEEEVRNLGTGEVTYSTQEHKADATPTDLSGAYVTATAVTTRTATTHEDL 1509

Human   954 ----ISETLEQK---------PHFESSTVKTETI----------------SFGSVSPG--GVKLE 987
                .:|.||:|         |:.:...|.|:.:                |..|.|.|  |..::
  Fly  1510 GKNAKTEQLEEKTVATTRTHDPNKQQQRVVTQEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPID 1574

Human   988 ISTKEVPVVHTE--------TKTIT---YESSQVDPGTDLEPGV-----LMSAQTITSETTSTTT 1036
            .......||.|:        |...|   .||::|..|.| .||.     ::|.||::|:|.:..|
  Fly  1575 GPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVLGED-TPGFSGHGEIISTQTVSSKTRTVET 1638

Human  1037 TTHITKTVKGGISETRIEKRIVITGDAD-IDHDQALAQAIKEAKEQHPDMSVTKVVVHKETE 1097
            .|:  ||.:.||.|||:|::|.|..|.| ||||:|||:||:||...:|||:|.|:.:.::|:
  Fly  1639 ITY--KTERDGIVETRVEQKITIQSDGDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQTQ 1698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPB41L3NP_001371614.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
B41 112..301 CDD:214604 108/189 (57%)
FERM_C_4_1_family 296..389 CDD:270005 81/92 (88%)
FA 398..441 CDD:400882 16/42 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..547 24/207 (12%)
Spectrin--actin-binding. /evidence=ECO:0000255 532..878 99/648 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581 9/23 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..733 10/67 (15%)
SAB 735..783 CDD:398195 16/144 (11%)
C-terminal (CTD) 879..1101 87/455 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 955..983 11/54 (20%)
4_1_CTD 992..1097 CDD:399118 47/121 (39%)
coraNP_523791.2 B41 34..224 CDD:214604 108/189 (57%)
FERM_N 36..98 CDD:286467 25/61 (41%)
FERM_M 116..224 CDD:278785 73/107 (68%)
FERM_C_4_1_family 219..312 CDD:270005 81/92 (88%)
FA 323..363 CDD:285894 16/41 (39%)
PQQ_2 829..>972 CDD:290097 21/143 (15%)
4_1_CTD 1612..1698 CDD:283537 38/88 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151662
Domainoid 1 1.000 168 1.000 Domainoid score I3823
eggNOG 1 0.900 - - E1_KOG3530
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 519 1.000 Inparanoid score I1279
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001068
OrthoInspector 1 1.000 - - otm41652
orthoMCL 1 0.900 - - OOG6_101605
Panther 1 1.100 - - O PTHR23280
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4459
SonicParanoid 1 1.000 - - X1151
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.780

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