Protein Alignment KDM6B and CYC8

DIOPT Version :10

• Sequence 1: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Sequence 2: NP_009670.3
• Gene: CYC8 / 852410
• SGDID: S000000316
• Length: 966
• Species: Saccharomyces cerevisiae
• Alignment Length: 883
• Identity: 162/883 - (18%)
• Similarity: 251/883 - (28%)
• Gaps: 241/883 - (27%)

Human     5 VDPPGARAAREAFALGGL-SCAGAWSSC----------PPHPPPR-SAWLPGGRCSASIG----- 52
            :||...:|....|.||.: ...|.||..          ||.|... ..|...|....|:|
Yeast   179 LDPHFEKANEIYFRLGIIYKHQGKWSQALECFRYILPQPPAPLQEWDIWFQLGSVLESMGEWQGA 243

Human    53 ---------QPPLPAPLPPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLH------------GC 96
                     |....|.:....|...|..:..:|.|    .:.|...|:||.            |.
Yeast   244 KEAYEHVLAQNQHHAKVLQQLGCLYGMSNVQFYDP----QKALDYLLKSLEADPSDATTWYHLGR 304

Human    97 V---------------QALLREPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPR 146
            |               ||:.|:...|..|..:|.||.......:|...|..|:|.....:|:...
Yeast   305 VHMIRTDYTAAYDAFQQAVNRDSRNPIFWCSIGVLYYQISQYRDALDAYTRAIRLNPYISEVWYD 369

Human   147 IGRLQQAQLWNFHTGSCQHR-AKVLPPLEQVWNL----LHLEHKRNYGAKRGGPPVKRAAEPPVV 206
            :|.|.:         :|.:: :..|...:|...|    :|:..:.....|:
Yeast   370 LGTLYE---------TCNNQLSDALDAYKQAARLDVNNVHIRERLEALTKQ-------------- 411

Human   207 QPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGL-PLPPPPLPPPPPPPPPPPPPL----- 265
                   |..|              |..::..|.|... |.|||.:..|...|.....||
Yeast   412 -------LENP--------------GNINKSNGAPTNASPAPPPVILQPTLQPNDQGNPLNTRIS 455

Human   266 --PGLATSP------PFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTA 322
              ...||:.      |.|.|.....:|::.:...|:.:..|..:.|.|..:.............|
Yeast   456 AQSANATASMVQQQHPAQQTPINSSATMYSNGASPQLQAQAQAQAQAQAQAQAQAQAQAQAQAQA 520

Human   323 HPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAP 387
            .........|...........|::.....|.....:..::.:.|:.:..................
Yeast   521 QAQAQAQAQAQAQAQAHAQAQAQAQAQAQAQAQAQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 585

Human   388 SRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGA 452
            .:...||     ..........::.:.|..|.|    |.|....:..|         ..:||  :
Yeast   586 QQLQPLP-----RQQLQQKGVSVQMLNPQQGQP----YITQPTVIQAH---------QLQPF--S 630

Human   453 PAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKG-PACRAAR-------EDGEILEELFF--- 506
            ..|..|      |.|...||..:.|:....|..|:| |..:|.:       |...:.::.:.
Yeast   631 TQAMEH------PQSSQLPPQQQQLQSVQHPQQLQGQPQAQAPQPLIQHNVEQNVLPQKRYMEGA 689

Human   507 -----------------GTEGPPRP--APPPLPHREGFLG--PPASRFSVGTQDSHTPPTPPTPT 550
                             .|:.|.:|  |.|......|...  |...:..:.:.:|:......|.|
Yeast   690 IHTLVDAAVSSSTHTENNTKSPRQPTHAIPTQAPATGITNAEPQVKKQKLNSPNSNINKLVNTAT 754

Human   551 TSSSNSNSGSHSSSPA------GPVSFPPPPYLARSIDPL------PRPPSPAQNPQDPPLV-PL 602
            :...|:.|...:.|||      ...|....|..|.||..:      |:..|||:.......| |.
Yeast   755 SIEENAKSEVSNQSPAVVESNTNNTSQEEKPVKANSIPSVIGAQEPPQEASPAEEATKAASVSPS 819

Human   603 TLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARG 667
            |..|...|.||..|.|..|    ||...:.:...|.|.               :......:||..
Yeast   820 TKPLNTEPESSSVQPTVSS----ESSTTKANDQSTAET---------------IELSTATVPAEA 865

Human   668 PRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASL 732
                    :|:||:..:                      ..:||....||. ||.....||.||.
Yeast   866 --------SPVEDEVRQ----------------------HSKEENGTTEAS-APSTEEAEPAASR 899

Human   733 QSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKK 770
            .:....|....||...:..|..|..|....|...||::
Yeast   900 DAEKQQDETAATTITVIKPTLETMETVKEEAKMREEEQ 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88		8/49 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680		93/548 (17%)
		PRK12323	<572..718	CDD:481241	30/152 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807		19/67 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325
		JmjC	1343..1407	CDD:214721
		JmjC	1377..1485	CDD:396791
CYC8	NP_009670.3	LapB	46..326	CDD:442196	30/150 (20%)
		TPR repeat	46..74	CDD:276809
		TPR repeat	80..108	CDD:276809
		TPR repeat	113..143	CDD:276809
		TPR repeat	150..178	CDD:276809
		TPR repeat	184..211	CDD:276809	7/26 (27%)
		TPR repeat	223..253	CDD:276809	4/29 (14%)
		TPR	251..>414	CDD:440225	34/196 (17%)
		TPR repeat	258..290	CDD:276809	8/35 (23%)
		TPR repeat	296..324	CDD:276809	4/27 (15%)
		TPR repeat	329..359	CDD:276809	8/29 (28%)
		TPR repeat	364..393	CDD:276809	6/37 (16%)
		MSCRAMM_ClfA	695..>910	CDD:468110	54/264 (20%)