Protein Alignment KDM6B and kdm6b

DIOPT Version :10

• Sequence 1: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Sequence 2: XP_031753875.1
• Gene: kdm6b / 779446
• XenbaseID: XB-GENE-6067077
• Length: 1740
• Species: Xenopus tropicalis
• Alignment Length: 1935
• Identity: 854/1935 - (44%)
• Similarity: 1024/1935 - (52%)
• Gaps: 501/1935 - (25%)

Human     1 MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHG 65
            |:|:.|..|:|..|::| :.|::.  .||  ||||.|   |.|..|||:::.||.||..||..|.
 Frog     1 MYRSQDQFGSRFPRDSF-ISGVNT--TWS--PPHPRP---WAPVSRCSSNMNQPQLPPYLPSGHV 57

Human    66 SSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEATRCY 130
            ::.||||||||...:| |.|..||||.:|.|||||||:..||.|||||||:||||.:.|:|..||
 Frog    58 TNLGHPSKPYYPISSP-PGPRIGKLERVHSCVQALLRDEQQPSLWEQLGQIYESEQEWEDAIHCY 121

Human   131 HSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGP 195
            .:|.||.|.: |||.||.|||||.:||.| .:..||.|.||||:|||:|:..|.||::||||..|
 Frog   122 QTAARYHGGY-ELGARISRLQQAHMWNMH-ATPHHRPKSLPPLQQVWDLMQHEQKRHFGAKRCLP 184

Human   196 PVKRAAEPPVVQPVPPAALSGPSGEEGLSP----GG-----KRRRGCNSEQTGL-PPGLPLPPPP 250
            .:||        ||||:    .|....|||    ||     ||||..:.||... .|||
 Frog   185 QLKR--------PVPPS----DSSALQLSPHNPHGGEEQPMKRRRSRSPEQQRRGNPGL------ 231

Human   251 LPPPPPPPPPPPPPLPGLATSPPFQL-TKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYP 314
                      ..||..|.:.|...|. .||.:|:.|....|...|      ||||.|.  ||...
 Frog   232 ----------HSPPASGGSGSLYHQAPVKPSVWNPLTHVPWAERR------ERQEPRP--PHAPS 278

Human   315 YPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAAT 379
            ||              |..||.|.|.||.....     .||| |||.|:|.||..  .:|.||..
 Frog   279 YP--------------PYCPPRPLPPPPPLHQQ-----PRPP-SDLSEARGQRCA--EAVPPAPP 321

Human   380 TACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHS 444
            ...|||...||...|.||..:..::||                |.||..|
 Frog   322 PLHVPYDQRRPRATPPTTPRTDLTTSS----------------DRYQNSA--------------- 355

Human   445 SRKPFLGAPA-ATPHL--SLPPGPSSPPPPPCPRLLRPPPP--PAWLKGPACRAAREDGEILEEL 504
                  |:|: ..|.|  .|.| |.:...|..|.:.|||||  ..||..|| :...:.|:.||::
 Frog   356 ------GSPSRICPPLVEQLDP-PQTICQPQLPAVSRPPPPLQQGWLPPPA-KEEMKKGDPLEDI 412

Human   505 FFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPV 569
            .:| :||.:      ..:|||. |.......|...:|.|....|....|.....||..
 Frog   413 LYG-DGPTK------VKQEGFY-PSRDTQREGNVYNHQPQGITTSKARSEAYQPGSLD------- 462

Human   570 SFPPPPYLARSIDP--LPRPPSPAQNPQDPPLVPLTLALPPAPPSSCH--QNTSGSFR----RPE 626
                  ::.:.:|.  |..|....:..|:....|||..|......|.|  ....||:.    .||
 Frog   463 ------HVLQKMDESGLIAPKKEEEIKQEVRNHPLTPELEVGGKQSSHGLSRAEGSYSGGKGSPE 521

Human   627 SPRPRVSFPKTPEVGPG--------PPPGPLSKAPQPVP--------PGVG------------EL 663
            . ....||  .|.:.|.        |.||.::...:|:|        |...            |.
 Frog   522 G-ADETSF--CPSLAPHHKDTSGSLPVPGSVALPAKPMPNLTRRPLSPNSAFSERTSVCGQEKEQ 583

Human   664 PARGPRLFDFPPTPLEDQFEEPAEF-KILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKE 727
            |....:||:||...|.:.|||.||| |||||||.:|||||||||.||||...:.:|:       :
 Frog   584 PTGCNQLFEFPGGQLHEPFEEAAEFAKILPDGLDDIMKMLDESIEKEEEGVGNASGM-------D 641

Human   728 PFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPP--PSQP 790
            ..:|..|..|    |..|.||.::.::..||...:               |||.||...  ||..
 Frog   642 DSSSTTSSSP----PAETMPASSLVSSNQTTVVKS---------------PPPNAKTAEVRPSDT 687

Human   791 QPPPPPPPS----------------PASLLKSLASVLEGQKYCYRG-------------TGAAVS 826
            .|...|..:                ..|:|||||:|||||||||||             |||.||
 Frog   688 FPYHGPKKAMLEQEASKEAKTAQHRGGSVLKSLANVLEGQKYCYRGSSGAKSAGNPAYFTGAMVS 752

Human   827 TR---PGPLPTTQY-----SPGPPSGATALPPTSAA----------------------------- 854
            .|   |....:|.:     .||...||.   |||.|
 Frog   753 KRNVDPYATQSTSHRAWDTKPGTHVGAA---PTSEALKPGVIEKRPEVRTETDILEDIARACETL 814

Human   855 -PSAQGS------------PQPSASSSSQFSTSGGPWARERRA---GEEPVPGPM---------T 894
             ..|:||            .:|..|...........|..|:|.   |...:.||:         :
 Frog   815 VEGAKGSAASRTGNERAVEKEPKKSEGIVDRKPDLQWGIEKRDIHWGANKLEGPVKQKVDFKWRS 879

Human   895 PTQ-------PPPPLSL----------------------PPARSESEVLE--------------- 915
            .||       |..|.:.                      |....:::|.|
 Frog   880 DTQKEVVEKKPEAPRATGQQDYVEKKHGADKPRVPVDRKPETLQKADVQEGVAEIKQETSYGTIR 944

Human   916 -EISRACETLVERVGRSAT---------DPAD--------------------------------- 937
             |::...|..:||..:.:.         .|||
 Frog   945 HEVAERLEAALERESKKSVKGAEKKCLPGPADSPSGTAREDPSKIHGANVKEAVKEATAKRLQGV 1009

Human   938 ------------------------------------------PVDTAEPADSGT---------ER 951
                                                      |:.|.|..|:||         ||
 Frog  1010 NDRESPKKNTDSLAQGGVSKNVAAEVAKPNADSKDTKSSEEAPMPTMEAGDNGTKGWEAGKPIER 1074

Human   952 L---LP-PAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRAC-KDSVGRRPREGRAKAKAKVPK 1011
            |   || ||::|||:          :||    :::||:.||.| |.|..||..           |
 Frog  1075 LTISLPAPARSKEES----------RRR----ERKHRKSRRDCSKKSTDRRSL-----------K 1114

Human  1012 EKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTA-----PAPPSAPAPSAQPTPPSASVPG 1071
            :|.|:|||||||||   |.|:.|...|..:|: |..|.     .|....|.|   ||||:::.|
 Frog  1115 DKERQVLGNLDLQS---QCRDTSNSTLKQSSR-KSETGRRGCEEAHHHQPTP---PTPPTSAPP- 1171

Human  1072 KKAREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTIS 1136
                   |...|.:.:|:||:|..:||||||||||||||||||:|||||||||||||:.::|||:
 Frog  1172 -------PTSHGTANSDLLKMRPFTEGPPKELKIRLIKVESGDRETFIASEVEERRLQASELTIN 1229

Human  1137 HCAADVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVL 1201
            :.||::|||:|:..:||||:||||.|:.||||.:.||:.||||||||||||||||||||||||:|
 Frog  1230 NTAAEIVRATRSMVLKGKFKESYLLPSMSVKPPLGTEQNLPREKLNPPTPSIYLESKRDAFSPIL 1294

Human  1202 LQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIW 1266
            |||||||:||||||||||||||||||||||||||:|:|||.||||||||||||||||.:||||||
 Frog  1295 LQFCTDPKNPITVIRGLAGSLRLNLGLFSTKTLVDANGEHMVEVRTQVQQPSDENWDPSGTRQIW 1359

Human  1267 PCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSA--PDPKNHHIIKFG 1329
            .|||||||||||||||||||||||||||:||| |::|.||||||.|||.|:  |:.|...|||||
 Frog  1360 HCESSRSHTTIAKYAQYQASSFQESLQEDKES-DDDSNEPDSTTETPPPSSTNPEHKTPQIIKFG 1423

Human  1330 TNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENN 1394
            |||||||.||||||||||.|||:||||||..||||||||||||||||||||||||||||||||||
 Frog  1424 TNIDLSDPKRWKPQLQELQKLPSFMRVTSNANMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENN 1488

Human  1395 NFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPG 1459
            |||||||||||||||||||||:|||.||||||:|.:|||||||||:|:|||.::|||||||||||
 Frog  1489 NFCSVNINIGPGDCEWFAVHENYWEKISAFCDKHNLDYLTGSWWPVLEDLYRADIPVYRFVQRPG 1553

Human  1460 DLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVART 1524
            ||||||||||||||||||||||||||||||.|||||||||:||||||||||||||||||||||||
 Frog  1554 DLVWINAGTVHWVQATGWCNNIAWNVGPLTPYQYQLALERFEWNEVKNVKSIVPMIHVSWNVART 1618

Human  1525 VKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVT 1589
            ||||||||::|||:||:||||.|.:||:||:|.|||||||.||||||||||||||||||||||||
 Frog  1619 VKISDPDLYRMIKYCLMQSMKRCVLQRDSLIRGGKKIAYQSRVKDEPAYYCNECDVEVFNILFVT 1683

Human  1590 SENGSRNTYLVHCEGCAR---RRSAGLQGVVVLEQYRTEELAQAYDAFTL 1636
            ||:|.:||||||||.|:|   ..|:....||:|||::||||...||.|.|
 Frog  1684 SESGGKNTYLVHCESCSRSASSASSASSNVVILEQFKTEELMHIYDNFHL 1733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88		18/35 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680		145/541 (27%)
		PRK12323	<572..718	CDD:481241	57/182 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807		29/120 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096		100/483 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325		24/38 (63%)
		JmjC	1343..1407	CDD:214721	59/63 (94%)
		JmjC	1377..1485	CDD:396791	97/107 (91%)
kdm6b	XP_031753875.1	LapB	<79..>134	CDD:442196	34/55 (62%)
		TPR repeat	98..126	CDD:276809	17/27 (63%)
		PHA03247	<188..571	CDD:223021	133/503 (26%)
		PTZ00121	<784..1259	CDD:173412	135/514 (26%)
		JmjC	1437..1501	CDD:214721	59/63 (94%)
		JmjC	1471..1579	CDD:396791	97/107 (91%)