Protein Alignment KDM6B and kdm6ba

DIOPT Version :10

• Sequence 1: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Sequence 2: XP_005172296.1
• Gene: kdm6ba / 556678
• ZFINID: ZDB-GENE-091005-1
• Length: 1996
• Species: Danio rerio
• Alignment Length: 2081
• Identity: 788/2081 - (37%)
• Similarity: 980/2081 - (47%)
• Gaps: 523/2081 - (25%)

Human     1 MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPLPPSHG 65
            ||...:.....:.|:.|.|.||: .|.|:     |....||.|..||...:.|..| .|..|||.
Zfish     1 MHHTAEQFTGCSTRDPFPLDGLN-RGPWA-----PVGSRAWPPPSRCLTGVNQHQL-LPHMPSHM 58

Human    66 SSSGHPSKPYYAPGAPTPRPLH--GKLESLHGCVQALLR-EPAQPGLWE--QLGQLYES-EHDSE 124
            :...|||| :...|     |:|  .|.:.....:.||.| .||.|..|:  :.||.||. ..|:.
Zfish    59 TGLNHPSK-FLNNG-----PIHRGDKQDQSQALMPALQRMPPAPPRPWDPTRAGQGYEPLPGDNH 117

Human   125 EATRCYHSALRYGGSFAELGPRIGRLQQA-QLWNF---HTGSCQHRAKVLPPLEQVWNLLHLE-- 183
            ...|..::|          ||......:| ||..|   |.....|.::.:.||..:|.....:
Zfish   118 NRLRNSYNA----------GPPSHLTARANQLLKFGAPHPQLATHGSRPIHPLPDLWTPPENQQQ 172

Human   184 ----HKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGLPPGL 244
                |..:...||.|||:   .|..|:|..||.:|..|.  |.|....||::...|||.......
Zfish   173 PRGTHSNSGQLKRPGPPL---GEHSVIQHTPPPSLHRPI--EDLPSPSKRKKSSGSEQIAHSAMQ 232

Human   245 PLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLH--GDAWGPERKGSAPPERQEQRH 307
            .|..|.:.....|....|||             |||.|:.||  |..|.|....|.|...|:...
Zfish   233 RLSGPTVHLNQQPSSHYPPP-------------KPGFWNPLHKVGAPWNPTEHKSGPIHFQDSAK 284

Human   308 SLPHPYPYPAPAYT-------------------AHPPGHRLVPAAPPGPGP-------------- 339
            ......||.||..:                   |.....:....:|...||
Zfish   285 PEVESIPYKAPPISLSTLSSPTINTTSGYGQSRASSSQSQKATQSPQSLGPPLQSPHIHHSAYSY 349

Human   340 ---RPPG---AESHGCLPA------TRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRP-- 390
               ||..   .|.||..|.      |.||......:.::..|...:.|||..|. |||  |.|
Zfish   350 SNNRPSDQSQGEPHGTTPQRGHHLDTPPPLIPKFSASLRADRERPAPSPANHTT-VPY--SHPQF 411

Human   391 ---PGLPGTTTSSSSSSS---------------------SNTGLRGVEPNPGIPGADHYQTPALE 431
               |||..:|:..:|:.:                     :.||:..:       .|.|.|.....
Zfish   412 QPHPGLVHSTSPPASNQAKATVPQHNLHKPWRNQESHDCAGTGVSQI-------AARHSQAHNSV 469

Human   432 VSHHG-----RLGPSAHSSRKPFLGAPAATPHL-----------SLPPGPSSP------------ 468
            |.:.|     .:.|...|:|||.:.....|||.           |:|...|:|
Zfish   470 VGNQGPRTPQHVSPPQASARKPVITPNLETPHPPCSLKPYTSVGSIPTMSSAPLTTSSIHSTLSI 534

Human   469 -PPPPCPRLLRPP---------PPPAWLKG--------PACRAAREDGEILEELFFGTEGP---- 511
             .|.....|:..|         ||....:|        |.....:...:.......|...|
Zfish   535 GRPTDSSVLMSNPNHLSMIGQNPPHLGYQGVHPGVGTLPHLHGVQSQIQQSTLTHTGQSRPNYTP 599

Human   512 ----------------------------PRPAPPPL--PH------REGFLGPPASRF--SVGTQ 538
                                        |:|...||  ||      ....|.|.:||.  ||.|:
Zfish   600 VSSTPSTLNSGLQRSGDSVITSKPSNTLPQPVSSPLSCPHPPAQIKANSILQPMSSRSYNSVTTE 664

Human   539 DSH-------TPPTPPTPTTS------------------------------------------SS 554
            .|.       |.|||..|.:|                                          ..
Zfish   665 SSSSISQATTTVPTPVYPGSSLQPTVPCSIADAFNKLDAELQGHMQAEERKRQQEEKRKQIVEKQ 729

Human   555 NSNSGSHSSSP--------AGPVSFPPPPYLA-----RSIDP----------LPR---PPSPA-- 591
            ..|:..|..|.        :|..:.||||.|:     .||.|          |.|   ||.|:
Zfish   730 EVNTKPHCESAIRSLERLLSGNTTEPPPPRLSPANAPSSISPSSQNSPPYPWLSRGGVPPRPSGI 794

Human   592 -----QNPQDPPLVPLT----------LALPPAPPSSCHQNTSG-SFRRPES------------- 627
                 :..|.|||.|.|          ..|....||   ||::| |....||
Zfish   795 SATIIEQSQPPPLTPQTEYAREKQRQREKLKSGTPS---QNSTGISTYHSESTLISTSNHNMQLK 856

Human   628 PRPRVSFP-KTPE----VGPGPPPGPLSKAP------------------------QPVPPGVGEL 663
            |.|...|. ||.:    :|..|.|.||.:.|                        |...|..| |
Zfish   857 PDPSKDFMLKTAQNIGIIGAIPNPPPLREQPKLYQAFHKDANPSCTLISMTENNLQKQIPSAG-L 920

Human   664 PARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEE------------QQQHE 716
            ...|.............||||... ::||||||||||||||||:||||            :.|..
Zfish   921 QGLGSNASSCSGDSDGAQFEEETS-ELLPDGLANIMKMLDESIKKEEELYSGQKGEQAVSELQFS 984

Human   717 AGVAP----------QPPLKEPFASLQSPFPTDTAPTTTAPAVAVT---TTTTTTTTTTATQEEE 768
            ..|||          .|.||      ||| ..|..|...|....::   :..:..:.|::.:|||
Zfish   985 TNVAPVKSYLCAPDLVPALK------QSP-AEDYQPDGHASPPVLSRQGSLASPCSRTSSLEEEE 1042

Human   769 KKPPPALPPPP-------------------------PLAKF------------------------ 784
            :....:|...|                         .|||.
Zfish  1043 EVLASSLKVIPKSANSNSVLSQDGSLATTGTNYRHSDLAKLYGISEVVKSECEDDEDEVDREDET 1107

Human   785 PPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPL---PTTQYSPGPPSGAT 846
            |..|.||.|........|:.|:||||||.|||.|||         ||.   |.:.:.....|.:.
Zfish  1108 PSCSPPQRPHLHQTGVNSMFKNLASVLESQKYTYRG---------GPFGRPPRSAFVGVKYSSSL 1163

Human   847 ALPP------TSAAPSAQGSPQPSASSSSQ---FSTSG-----GPWA--RERRAGEEPVPGPMTP 895
            :|.|      .|.:|::..:..|..||.:|   .|.||     .|.:  .|.:.|::..|..:..
Zfish  1164 SLGPDICRQQQSTSPTSGSASHPGFSSPTQTSAISNSGQTCPLSPTSCESESKRGDKISPSDLLG 1228

Human   896 TQPPPPLSLPP-----ARSESEVLE---EISRACETLVERVGRSATDPADPVDTAEPADSGTERL 952
            ......:|..|     :.:..::||   :::...|:.:..:|:|.......:...:.:.:....:
Zfish  1229 NDDEKDISEEPKVKVDSGNMKDLLERRPKLTTISESSLAELGQSLEVNKHIIPFKDHSKAEAREI 1293

Human   953 LPPAQAKE-----EAGGVAAVSGSCKRRQ--KEHQKEHR-RHRRA-----CKDSVGRRPREGRAK 1004
            ..|.:.||     |.......|.|.|:.:  ||.:|:|| ||..|     ...|..||.|:|::.
Zfish  1294 CKPVEEKERHRDRERERKHKHSSSSKKHEDKKERKKKHRERHDDASLSSSSSSSSSRRHRDGKSH 1358

Human  1005 AKAKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASV 1069
                 .::|||:|||||||||:|::.:|:.|   .|..|.:...:..|.:......|     ...
Zfish  1359 -----KEKKSRQVLGNLDLQSKELREKEQER---DGDKKRRKEESGRPQNEGEAWTQ-----IRE 1410

Human  1070 PGKKAREEAPGPPGVSRA---DMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMA 1131
            .|..:...:..|.|.|..   |..||::|::|||||||||||||||||:||||||||||:|:.:.
Zfish  1411 KGSSSGHSSDLPSGSSALCSDDFQKLKALTDGPPKELKIRLIKVESGDRETFIASEVEEKRIPLK 1475

Human  1132 DLTISHCAADVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDA 1196
            |:||.:.|::::||.:.|:|||||:||||..|.||||.:.||..:||||||||||||||||||||
Zfish  1476 DITIKNSASEIIRACKAARVKGKFKESYLLDAFSVKPVVRTELPIPREKLNPPTPSIYLESKRDA 1540

Human  1197 FSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTG 1261
            ||||||||||||:|||||||||||||||||||||||:||||:.||.||||||||||:|||||.:|
Zfish  1541 FSPVLLQFCTDPKNPITVIRGLAGSLRLNLGLFSTKSLVEANSEHAVEVRTQVQQPADENWDASG 1605

Human  1262 TRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTT----GTPPSSAPDPKN 1322
            |.|.|||||||||||||||||||||||||||||||.|:.||..:...||    .|..||||:..:
Zfish  1606 TGQTWPCESSRSHTTIAKYAQYQASSFQESLQEEKGSDAEEDNDEKPTTKAESTTSNSSAPNSSS 1670

Human  1323 HH-----IIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKV 1382
            ..     ||||||||||||.||||||||||.||||||||:|:||||||||||||||||||||||:
Zfish  1671 EQKTVGKIIKFGTNIDLSDPKRWKPQLQELQKLPAFMRVSSSGNMLSHVGHTILGMNTVQLYMKI 1735

Human  1383 PGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYAS 1447
            ||.|||||||||||||||||||||||||||||:.|||.||.||.:||||||||||||:|||||.:
Zfish  1736 PGCRTPGHQENNNFCSVNINIGPGDCEWFAVHDDYWEAISDFCQKHGVDYLTGSWWPVLDDLYRA 1800

Human  1448 NIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIV 1512
            |||||||:|||||||||||||||||||.||||||||||||:.|||||:||||:||||||.|||||
Zfish  1801 NIPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPVNAYQYQVALERFEWNEVKKVKSIV 1865

Human  1513 PMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNE 1577
            ||||||||||||||::|||.:.|||.|||||:||.|:.|:.||.||.||:||.||||||||||||
Zfish  1866 PMIHVSWNVARTVKVTDPDAYNMIKHCLLQSIKHIQILRDQLVAAGMKISYQSRVKDEPAYYCNE 1930

Human  1578 CDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLVRARRA 1642
            |||||||:||||||||||..|:||||.|||:||..|..||||||||.|||...||:|:|..:..:
Zfish  1931 CDVEVFNLLFVTSENGSRKMYVVHCEDCARQRSPNLSNVVVLEQYRMEELMNMYDSFSLAVSPSS 1995

Human  1643 R 1643
            |
Zfish  1996 R 1996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88		13/37 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680		165/785 (21%)
		PRK12323	<572..718	CDD:481241	69/235 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807		36/176 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096		72/316 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325		19/45 (42%)
		JmjC	1343..1407	CDD:214721	58/63 (92%)
		JmjC	1377..1485	CDD:396791	94/107 (88%)
kdm6ba	XP_005172296.1	Atrophin-1	273..>657	CDD:460830	72/393 (18%)
		JmjC	1696..1760	CDD:214721	58/63 (92%)
		JmjC	1730..1838	CDD:396791	94/107 (88%)