DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDM6B and ssn6

DIOPT Version :10

Sequence 1:NP_001073893.1 Gene:KDM6B / 23135 HGNCID:29012 Length:1682 Species:Homo sapiens
Sequence 2:NP_596609.1 Gene:ssn6 / 2540656 PomBaseID:SPBC23E6.09 Length:1102 Species:Schizosaccharomyces pombe


Alignment Length:1347 Identity:246/1347 - (18%)
Similarity:391/1347 - (29%) Gaps:522/1347 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   264 PLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHR 328
            |...:||:.|.|..:|.     ||  .|.:...|.|      ..|||     |..||.|.|. |.
pombe     2 PQSQVATASPSQNAQPN-----HG--MGSKVLSSDP------NASLP-----PQTAYYASPL-HA 47

Human   329 LVPAAPPGPGPRPPGAESHGCL-----PATRPPGSDLRESRVQRSRMDSSVS-PAATTACVP--- 384
            ...:.||...||   :..|..|     ||.:.|.....:..:|:....|..| |....|.||   
pombe    48 NSVSLPPSHLPR---STLHPLLSQQQQPAQQSPSLGPAQQNIQQPPSVSIASQPHYAEAIVPIQQ 109

Human   385 -YAPSR----PPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHS 444
             ..|.:    ||.:...|.:..                        |.|.|:     |:.|.. |
pombe   110 VLQPQQYRQLPPNMVAATNAPQ------------------------QHPQLQ-----RMMPIL-S 144

Human   445 SRKPFLGAP---AATPHLSLP---PGPSSPPPPP------CPRLLRPPPPP-----------AWL 486
            |.:|....|   .|:|::.:|   ...|.|...|      .|:..:||..|           :.:
pombe   145 SNQPIQQLPLPNQASPYIPVPLQQQQQSQPQQQPQQQQHQQPQQPQPPQQPLQQQQQQRQLHSGI 209

Human   487 KGPACRAAREDGEILEELFFGTEGPPRP--------APPPLPHREGFLGPPASRFSVGTQDSHTP 543
            :.|......::|     .::.......|        ||.|.|::...                 |
pombe   210 QQPVSTIVSQNG-----TYYSIPAVNHPMAGQPIAIAPVPAPNQAAL-----------------P 252

Human   544 PTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQN--PQDPPLVPLTLA- 605
            |.||....::...|      :.|.||:.|......::..|:|...|||..  ||:......||| 
pombe   253 PIPPQALPANGTPN------TLASPVTLPAANSAVQNAQPVPMTSSPAMAVVPQNKTAATSTLAA 311

Human   606 ------LPP-APPS-----SCHQNT----------------------SGSFRRPES-P------- 628
                  ||| ||.|     |.::.|                      |...:.|.| |       
pombe   312 QQGANVLPPNAPESVRHLISLNEETWIQIGRLAELFDDQDKALSAYESALRQNPYSIPAMLQIAT 376

Human   629 --RPRVSFPKTPE-----VGPGPPPG--------------PLSKA-----------PQPVPP--- 658
              |.|..||...|     :...|..|              .||:|           ..|..|   
pombe   377 ILRNREQFPLAIEYYQTILDCDPKQGEIWSALGHCYLMQDDLSRAYSAYRQALYHLKDPKDPKLW 441

Human   659 -GVGEL---------------------P----------------------ARGPRLF----DFPP 675
             |:|.|                     |                      |:...||    |.||
pombe   442 YGIGILYDRYGSHEHAEEAFMQCLRMDPNFEKVNEIYFRLGIIYKQQHKFAQSLELFRHILDNPP 506

Human   676 TPLE---------DQFEEPAEFKILPDGLANIM-------------------------------K 700
            .||.         ..:|:..|:|:..:....::                               :
pombe   507 KPLTVLDIYFQIGHVYEQRKEYKLAKEAYERVLAETPNHAKVLQQLGWLCHQQSSSFTNQDLAIQ 571

Human   701 MLDESIRKEEEQQQH-----EAGVAPQPPLKEPFASLQSPFPTDTAPT----------------- 743
            .|.:|:..::...|.     ...||.|...|...|..|:.:.....||                 
pombe   572 YLTKSLEADDTDAQSWYLIGRCYVAQQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYQD 636

Human   744 ---TTAPAVAVTTTTTTTTTTTATQEE--EKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASL 803
               ..:.|:.:....:.......|..|  ..:...||......|:. .|:.|.            
pombe   637 ALDAYSRAIRLNPYISEVWYDLGTLYESCHNQISDALDAYQRAAEL-DPTNPH------------ 688

Human   804 LKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYS-----PGPPSGATALPPTSAAPSAQGSPQP 863
            :|:...:|.|..   ......|:..|..:|..|.:     ||        .|.|..|.||.|   
pombe   689 IKARLQLLRGPN---NEQHKIVNAPPSNVPNVQTAKYINQPG--------VPYSNVPVAQLS--- 739

Human   864 SASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPP--PPLSLPPARSESEVLEEISRACETLVE 926
                        |.|                  |||  |...||.|..:|.|:::..:...::..
pombe   740 ------------GNW------------------QPPHLPQAQLPSATGQSGVVQQPYQTQPSVTN 774

Human   927 RVGRSATDP----ADPVDTAEPADSGTERLLPPA---------QAKEEAGGVAAVSGSCKRRQKE 978
              ...||.|    ..||.||.|:   ::..:|..         :.|..:|...::|.:...:.|.
pombe   775 --NNVATQPVIASTVPVQTAAPS---SQTAVPQTIHQSNAFTPRGKHASGSRNSISSTKSPQHKL 834

Human   979 HQKEHRRH-------RRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRP 1036
            ..:...|:       .|...:||..:.||.|..|..:...:||.:...:..|::..:.....|..
pombe   835 SDQPRSRNNSISNVSHRERSNSVSSKSRETRTSASNESDPKKSTQRDSSKKLENSTVVSGSPSSS 899

Human  1037 DLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGPPK 1101
            ....|:|:      ..|..|.|:.:|...:|.                               ||
pombe   900 SKSDAAKS------IKPQKPEPALKPVEGTAD-------------------------------PK 927

Human  1102 ELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASRNAKVKGKFRESYLSPAQSV 1166
            ..|....:.|                 :.||..:|  :.:.|:..:.|.|.....|..:.  |||
pombe   928 STKRNHQETE-----------------KTADTDVS--STEPVKRQKTADVNDDVGEEEVK--QSV 971

Human  1167 KPKINTEE--KLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLF 1229
            ..::::.:  ..|:.:..|.:|    |.|.|           |..|.:|                
pombe   972 SEQVDSAQLTSEPKSESLPKSP----EEKSD-----------DTSNDVT---------------- 1005

Human  1230 STKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQE 1294
             |:...:.:|:..::....|    |::.|...|          |..|:|.    ..::.:|.| .
pombe  1006 -TENTNDINGDSNMDNVATV----DKSTDAVDT----------STATVAA----TTTTAEEEL-P 1050

Human  1295 EKESEDEESEEPDSTTGTP--PSSAPDPKNHHIIKFGTNIDLSDAKR 1339
            :|||::..|..|::...||  |.|....:....:....|.|..:.::
pombe  1051 QKESQERSSPSPENQDSTPLAPKSVSPKQAARTLDIDENYDDDEGEK 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM6BNP_001073893.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..88
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..680 121/597 (20%)
PRK12323 <572..718 CDD:481241 53/318 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..807 19/129 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1096 55/300 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1325 11/38 (29%)
JmjC 1343..1407 CDD:214721
JmjC 1377..1485 CDD:396791
ssn6NP_596609.1 PHA03247 <2..299 CDD:223021 80/376 (21%)
TPR repeat 335..362 CDD:276809 2/26 (8%)
LapB 337..614 CDD:442196 40/276 (14%)
TPR repeat 367..397 CDD:276809 7/29 (24%)
TPR repeat 403..430 CDD:276809 3/26 (12%)
TPR repeat 437..467 CDD:276809 4/29 (14%)
TPR repeat 472..503 CDD:276809 3/30 (10%)
TPR repeat 512..540 CDD:276809 3/27 (11%)
TPR repeat 546..578 CDD:276809 2/31 (6%)
NrfG 569..687 CDD:443378 18/118 (15%)
TPR repeat 584..612 CDD:276809 7/27 (26%)
TPR repeat 617..647 CDD:276809 3/29 (10%)
TPR repeat 652..681 CDD:276809 4/28 (14%)
PHA03246 <712..883 CDD:223020 44/216 (20%)
PRK08581 832..>1028 CDD:236304 47/289 (16%)
Blue background indicates that the domain is not in the aligned region.

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