Protein Alignment KDM6B and utx-1

DIOPT Version :10

• Sequence 1: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Sequence 2: NP_001309685.1
• Gene: utx-1 / 181110
• WormBaseID: WBGene00017046
• Length: 1146
• Species: Caenorhabditis elegans
• Alignment Length: 739
• Identity: 238/739 - (32%)
• Similarity: 364/739 - (49%)
• Gaps: 167/739 - (22%)

Human  1047 PTAPAPPSA-----------PAPSAQPTPPSAS------VPGKKAREEAPGPPGVSRADMLKLRS 1094
            |.||.|..|           |.| |:|:..::|      :|..|...|.|.|        |:||:
 Worm   419 PVAPEPIKARVQFLEKELSMPVP-ARPSNHASSSTFETVIPSLKEAYEQPIP--------LELRN 474

Human  1095 LSEG---------------------------------------PPKELKIRLIKVESGDKETFIA 1120
            ..:.                                       |.::|:|:::::...::...:.
 Worm   475 RQDAAYADREAQYDNAFWDLWEDFRTMEHEKPEDMEWDVTYPRPMEDLEIQVMQLLRANEPALVK 539

Human  1121 SEVEER----------RLRMADLTISHCAADVVRAS----RNAKVKGKFRES------------- 1158
            :|.|..          :.::.:..|.....::.|.:    :|.:..|...||
 Worm   540 AEREVLECLETSEAVFKAKVIEYVIPEAVREMPRVTEEMIQNLRDHGHLLESPRCYSFPFLPKIS 604

Human  1159 --------------YLS-----------------------------------PAQSVKPKINTEE 1174
                          |:|                                   |...|||.:..|:
 Worm   605 FNDLPDSFSLLSELYVSMDISAQEIMQMVHRRTQPNSTYLPVFEEFAKLPEPPRGPVKPIVTDED 669

Human  1175 ---KLPREKLNP---PTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKT 1233
               .|.|.:.:|   .||.:.::::::|.|..|.:|...  :.|:.||||.|.|||:|.|||||.
 Worm   670 VRTALERSEKHPLILKTPILTVDNRKEAQSLELQRFLDG--STISCIRGLTGCLRLDLSLFSTKA 732

Human  1234 LVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKES 1298
            :.|..|...:|:|||.|.|.:.|.| ..::|.|.|.|..|:||:.|||:||:.||:.:|:.|.|
 Worm   733 VAEIDGNQEIEIRTQYQLPPETNCD-HASQQTWQCVSDPSYTTVNKYAEYQSESFKHTLKGEAE- 795

Human  1299 EDEESEEPDSTTGTPP--------SSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMR 1355
              :..:....|.|..|        :|:| ||:...||:||||||||..:|..|:.||.|||||.|
 Worm   796 --KIKKNVGGTRGPSPKRMKLYKRASSP-PKHLKSIKYGTNIDLSDDTKWGKQINELSKLPAFCR 857

Human  1356 VTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWET 1420
            :.:..|||||:||.:.|||||:|:|||||.|||.||::|:..|:||||||||||||||...||..
 Worm   858 LIAGSNMLSHLGHQVHGMNTVKLFMKVPGCRTPAHQDSNHMASININIGPGDCEWFAVPYEYWGK 922

Human  1421 ISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNV 1485
            :...|:::|||.|||::|||:|||..:.|||:||.|:.||:|:::.|.:|||||:||||||:|||
 Worm   923 MHKLCEKNGVDLLTGTFWPIIDDLLDAGIPVHRFTQKAGDMVYVSGGAIHWVQASGWCNNISWNV 987

Human  1486 GPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQ 1550
            .||...|..::|..||:|:::..||.|||..:.|.||:.||.::..::...|..|::|:...::.
 Worm   988 APLNFQQLSISLLSYEYNKLRRFKSEVPMQLMCWQVAKNVKFTNQLIYNTCKGVLIRSLAFLRMV 1052

Human  1551 RESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQG 1615
            .:.:|...|.|....|...|.:::|..|:.|||.||||....|....:.|:|     .:|.|::|
 Worm  1053 ADYIVSQKKTIKAHTRTSGEQSHFCMTCECEVFCILFVKDIGGKFTVFCVYC-----AKSQGIEG 1112

Human  1616 VVVLEQYRTEELAQAYDAFTLVRA 1639
            .:.|:|:...:|...||....:.|
 Worm  1113 FIALQQFSFTDLYSIYDNMKYIPA 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680
		PRK12323	<572..718	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096		18/65 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325		11/44 (25%)
		JmjC	1343..1407	CDD:214721	40/63 (63%)
		JmjC	1377..1485	CDD:396791	64/107 (60%)
utx-1	NP_001309685.1	CpoB	70..183	CDD:441335
		TPR repeat	138..168	CDD:276809
		LapB	142..435	CDD:442196	5/15 (33%)
		TPR repeat	176..203	CDD:276809
		TPR repeat	271..301	CDD:276809
		TPR repeat	315..348	CDD:276809
		TPR repeat	353..383	CDD:276809
		TPR repeat	388..415	CDD:276809
		JmjC	845..909	CDD:214721	40/63 (63%)
		JmjC	879..987	CDD:396791	64/107 (60%)