DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF8 and Kdm2

DIOPT Version :9

Sequence 1:	XP_005262053.1	Gene:	PHF8 / 23133	HGNCID:	20672	Length:	1085	Species:	Homo sapiens
Sequence 2:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster

Alignment Length:	1102	Identity:	290/1102 - (26%)
Similarity:	415/1102 - (37%)	Gaps:	331/1102 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   102 RGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKK 166
            ||.|........|..:.|   .|||:|               |..|||.||:::.|::|:|...|
  Fly    68 RGFSVAEKLESSKFAQAG---MVREMR---------------GCDLTVAFLQQHGFNIPLLFRDK 114

Human   167 DGLGMTLPSP-SFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLE 230
            .|||:.:|.| .|||.||...|||.:.:||:||..|.:.:|.:.::.:||.|.:::::|||||||
  Fly   115 AGLGLRMPDPQEFTVNDVRLCVGSRRLLDVMDVNTQKNLQMTMKEWQQYYDSPQKDRLLNVISLE 179

Human   231 FSDTRLSNLVETPKIVRKLSWVENLWPEECVFER------------PNVQKYCLMSVRDSYTDFH 283
            ||.|||...|::|:|||::.||:.:||::....:            |.|||||||||::.|||||
  Fly   180 FSHTRLDRFVQSPEIVRQIDWVDVVWPKQLKDAQREGTNLLGGMMYPKVQKYCLMSVKNCYTDFH 244

Human   284 IDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLF 348
            |||||||||||:|:|.|:|:||.||:.||.|:|.|..|..|.::||||.|:||.:..:..|.|.|
  Fly   245 IDFGGTSVWYHILRGSKVFWLIPPTDRNLQLYEKWVLSGKQADIFFGDTVEKCARVYLTAGNTFF 309

Human   349 IPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYV------ 407
            |||||||||.||...|.||||||||..|..|||...:|........||:|.|..:.|||
  Fly   310 IPTGWIHAVYTPTQSLVFGGNFLHSFGIVKQLKTASVEDSTKVPQKFRYPFFTEMLWYVLARYVH 374

Human   408 ---GKHILDIFRGLRENR--RHPASYLVHGGKALNLAFRAWTRKEA------LPDHEDEIPETV- 460
               |...|:....|.|:.  ..|.::|.|        ...:..||.      ||..:..:|..|
  Fly   375 TLLGHSHLEGEASLSEDEMAARPHTHLTH--------HELFGLKEIVMYLYDLPPQKKNVPSLVL 431

Human   461 RTVQLIKDLAREI-RLVEDIFQQNVGKTSNIFGLQRI-FPAGSIP------LTRPAHSTSVSMSR 517
            ..|.||||:...: |..:|  ||::.    |.|:..: .|.||.|      .||........::|
  Fly   432 DPVALIKDVRSLVERHCKD--QQDLA----ITGVSVLKSPPGSQPPFLLYDRTRVKQEIKQEIAR 490

Human   518 LSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNIT 582
                 ||....:..:..|..:..|.:...|.:.|....:.......||:..:|....:    |.:
  Fly   491 -----KNAEVIREQQQLEAGRAREAESDTSQSTGVGSVIGMGAGVEYSNGVMKKEQLE----NGS 546

Human   583 GACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEF 647
            |..:.                      .:||..                            |..|
  Fly   547 GVTVG----------------------GHGSQP----------------------------EATF 561

Human   648 DLDSDDELQIDERLGKEKATLIIRPKFPRKLPR-----AKPCSDPNRVREPGEVEFDIEEDYTTD 707
            .|.:|              ||..||  |:|:..     |...|..:....|
  Fly   562 ALPTD--------------TLKYRP--PKKMHLATALVAAAASSSSGGGGP-------------- 596

Human   708 EDMVEGVEGK-------------LGNGSGAGGILDLLKASRQV--GGPDYAALTEAPASPSTQEA 757
               |.||.|.             :|..:||||.:.::..|...  ||                 .
  Fly   597 ---VAGVGGSAVVGSSHSPTGGGVGPVTGAGGAISVIATSSSYIEGG-----------------Q 641

Human   758 IQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRT------------ 810
            :.|:|.|.|..|.....|..|.....| ||.|...:      ...|..|.||:
  Fly   642 VGGILNMDNCHSPEGGGAKLSPNLTGT-GQPRRRRT------RCKNCAACQRSDCGTCPFCMDMV 699

Human   811 ----PGKR--------------PIKRPAY------WRTE--SEEEEENASLDEQDSLGACFKDAE 849
                ||:.              |:.....      ||..  |.:.::.||.|...:|..|....|
  Fly   700 KFGGPGRAKQTCMMRQCLSPMLPVTAQCVYCHLDGWRQTPVSPQTKQLASADGPSALMECSVCYE 764

Human   850 YIYP-----SLESDDDDPALK--------------SRPKKKKNSDDAPWSPKARVTPTLPKQDRP 895
            ..:|     .|:..:|....|              |..:..||.|..|...:||      ::...
  Fly   765 IAHPDCALSQLDGTEDAADAKGIVNEDLPNSWECPSCCRSGKNYDYKPRHFRAR------QKSSE 823

Human   896 VREGTRVASIETGLAAAAAK-------------------LAQQELQKAQKK------KYIKKKPL 935
            ||.    .|:..|...|...                   .::.|::.....      |:..|:..
  Fly   824 VRR----VSVSHGQGGAEGHADGNTLLPPPVGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHH 884

Human   936 LKEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARP------ 994
            ..||:..|    |.|...|:|.:  :|..:...|.:.......:..|.|.:.||....|
  Fly   885 QLEVKTER----NNSCDTPSPGI--SPNAIGGDSKVGKRRKSDDGTSVSSSMHESNDAPCGSSAE 943

Human   995 NAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLAT--AKQRLG---RILK 1051
            .|.|...||.||...:               .:..|.|.|.|..:.:  |:|.|.   |:||
  Fly   944 GAGGAGNANVSTNQWS---------------GSGGGGGSRKKNSIRSQLAQQMLNSSTRVLK 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF8	XP_005262053.1	PHD_PHF8	42..93	CDD:277112
		JmjC	235..298	CDD:214721	38/74 (51%)
		cupin_like	270..370	CDD:304367	62/99 (63%)
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367	62/99 (63%)
		PRTases_typeI	<394..>467	CDD:294217	21/86 (24%)
		zf-CXXC	670..716	CDD:251032	8/51 (16%)
		PHD_4	721..801	CDD:293471	14/79 (18%)
		F-box-like	<1073..1108	CDD:289689
		leucine-rich repeat	1102..1125	CDD:275381
		leucine-rich repeat	1126..1149	CDD:275381
		leucine-rich repeat	1150..1173	CDD:275381
		AMN1	1166..>1320	CDD:187754
		leucine-rich repeat	1174..1213	CDD:275381
		leucine-rich repeat	1214..1238	CDD:275381
		leucine-rich repeat	1239..1267	CDD:275381
		leucine-rich repeat	1268..1292	CDD:275381
		leucine-rich repeat	1293..1317	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1633
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000253
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810