DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RAD54L2 and STH1

DIOPT Version :9

Sequence 1:NP_001309182.1 Gene:RAD54L2 / 23132 HGNCID:29123 Length:1467 Species:Homo sapiens
Sequence 2:NP_012140.1 Gene:STH1 / 854680 SGDID:S000001388 Length:1359 Species:Saccharomyces cerevisiae


Alignment Length:1362 Identity:303/1362 - (22%)
Similarity:503/1362 - (36%) Gaps:445/1362 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    10 DPDLDPDVELEDAEEEEEEEEV-------AVEEC----DRDDEEDLLDDPSLEGMCGTEHAQLGE 63
            |||.:..:....:....|.|.:       ::::|    .:||....:|...::.:...:..:|  
Yeast   188 DPDTEIRISARISNRINELERLPANLGTYSLDDCLEFITKDDLSSRMDTFKIKALVELKSLKL-- 250

Human    64 DGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKA 128
                      .|..:|     :|:....|:||:          :|  .|| ..||:   .|.|.|
Yeast   251 ----------LTKQKS-----IRQKLINNVASQ----------AH--HNI-PYLRD---SPFTAA 284

Human   129 AQQ-----------------EELERRKRLEQQRKD---YAAPIPTVPLEFLPEEIA--------- 164
            ||:                 |||||::.||:::|:   :...|.:: ::|:.|..:         
Yeast   285 AQRSVQIRSKVIVPQTVRLAEELERQQLLEKRKKERNLHLQKINSI-IDFIKERQSEQWSRQERC 348

Human   165 -----LRAS-------DGPQLPPRVLAQEVICLDSSSGS------EDEKSSR------------D 199
                 |.||       |..:...|...|.:..|.|:...      :..|.:|            |
Yeast   349 FQFGRLGASLHNQMEKDEQKRIERTAKQRLAALKSNDEEAYLKLLDQTKDTRITQLLRQTNSFLD 413

Human   200 EVIELSSGEEDTLHIVDSSESVSEDDEEEEKGGTHVNDVLNQRDALGRVLVNLNHPPEEENVFLA 264
            .:.|....:::...|:...|.....|||.||  |...:|.:      |:...::..|   ::.:.
Yeast   414 SLSEAVRAQQNEAKILHGEEVQPITDEEREK--TDYYEVAH------RIKEKIDKQP---SILVG 467

Human   265 PQLARAVKPHQIGGIRF---LYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHT 326
            ..|    |.:|:.|:.:   ||:|.:..            |||..||||||:|.||.|..|:.  
Yeast   468 GTL----KEYQLRGLEWMVSLYNNHLNG------------ILADEMGLGKTIQSISLITYLYE-- 514

Human   327 PAKTV---LAIVPVNTLQNWLAEFNMWLPPPEALPADNKPEEVQPRFFKVHILNDEHKTMASRAK 388
            ..|.:   |.|||::|:.||..||..|.|....:.....|.:......::.:.|.:         
Yeast   515 VKKDIGPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPNQRHSLQHQIRVGNFD--------- 570

Human   389 VMADWVSEGGVLLMGYEMY---RLLTLKKSFATGRPKKTKKRSHPVIIDLDEEDRQQEFRREFEK 450
                      |||..||..   :.|..|..:|           |.:|                  
Yeast   571 ----------VLLTTYEYIIKDKSLLSKHDWA-----------HMII------------------ 596

Human   451 ALCRPGPDVVICDEGHRIKNCQASTSQALKN-IRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFL 514
                        |||||:||.|:..|..:.: .|:|.|::|||.||||||.|.|.:::||.|...
Yeast   597 ------------DEGHRMKNAQSKLSFTISHYYRTRNRLILTGTPLQNNLPELWALLNFVLPKIF 649

Human   515 GTRQEFSNMFERPILN---GQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEE 576
            .:.:.|.:.|..|..|   .:.::.|.::..|:..|   ||.:|..|:.||....::..||.|.|
Yeast   650 NSAKTFEDWFNTPFANTGTQEKLELTEEETLLIIRR---LHKVLRPFLLRRLKKEVEKDLPDKVE 711

Human   577 NVILVRLSKIQRDLYTQFMDR---FRDCGSSGWL-----GLN----PLKAFCVCCKIWNHPDVLY 629
            .||..:||.:|:.||.|.:..   |...|:.|..     |||    .|:..|      |||.|..
Yeast   712 KVIKCKLSGLQQQLYQQMLKHNALFVGAGTEGATKGGIKGLNNKIMQLRKIC------NHPFVFD 770

Human   630 EALQKESLANEQDLDVEELGSAGTSARCPPQGTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQE 694
            |                                                     ::|| .||  .
Yeast   771 E-----------------------------------------------------VEGV-VNP--S 779

Human   695 RGNNIVTYEWAKDLLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGK 759
            |||:        |||       ...:.|..||..::.:....|.::|:|.|....:.::|:||. 
Yeast   780 RGNS--------DLL-------FRVAGKFELLDRVLPKFKASGHRVLMFFQMTQVMDIMEDFLR- 828

Human   760 REVPCPPGTEGQGAQKWVRNISYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVN 824
                             ::::.|.||||||...||..::|.||.|.: ..:.||||||||.||:|
Yeast   829 -----------------MKDLKYMRLDGSTKTEERTEMLNAFNAPDS-DYFCFLLSTRAGGLGLN 875

Human   825 LIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVV 889
            |..|:.|::||..|||..|.||..|.:|.|||....|.||:...::|:.|.:|.:.|..:..:|:
Yeast   876 LQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKLDIDGKVI 940

Human   890 --------------------------------------DDLNPMLNFTRKEVENLL-HFVEKEPA 915
                                                  |:||..|  .|...|.:| ..::||..
Yeast   941 QAGKFDNKSTAEEQEAFLRRLIESETNRDDDDKAELDDDELNDTL--ARSADEKILFDKIDKERM 1003

Human   916 PQVSLNVK--GIKESVLQLACL-KYPHLITKEPFEHESLLLNRKDHK-LTKAEKKAAKKSYEEDK 976
            .|...:.|  |::....:|..| :.|.:..::..||    ..::|.: |.:..:|  |:.|.:|.
Yeast  1004 NQERADAKAQGLRVPPPRLIQLDELPKVFREDIEEH----FKKEDSEPLGRIRQK--KRVYYDDG 1062

Human   977 RTSVPYTRPSYAQYYPA-SDQSLTSIPAFSQR---NWQPTLKGDEKPVASVRPVQSTPIPMMPRH 1037
            .|.        .|:..| .|.:::...|..:|   ..:..|:.:......:..:::||.......
Yeast  1063 LTE--------EQFLEAVEDDNMSLEDAIKKRREARERRRLRQNGTKENEIETLENTPEASETSL 1119

Human  1038 VPLGGSVSSA--SSTNPSMNFPINYLQRAGVLVQK---VVTTTDIVIPGLNSSTDVQARINAG-- 1095
            :. ..|.::|  ..||.......:..:|.....::   :||..|    ..|:..:..::.|.|  
Yeast  1120 IE-NNSFTAAVDEETNADKETTASRSKRRSSRKKRTISIVTAED----KENTQEESTSQENGGAK 1179

Human  1096 -------ESIHIIRGT----------------KGTYIRTSDGRIFAVRATGKPKVPEDGRMAASG 1137
                   .|:.||.|:                |.|.:..:||:    ||..||            
Yeast  1180 VEEEVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGK----RAEEKP------------ 1228

Human  1138 SQGPSCESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTN 1199
                  ||.|..:.:|:.......:.|.  :.|...:::.|:::..|..      .|.|.|:
Yeast  1229 ------ESKSPAKKTAAKKTKTKSKSLG--IFPTVEKLVEEMREQLDEV------DSHPRTS 1276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RAD54L2NP_001309182.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..150 34/170 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..234 12/65 (18%)
SNF2_N 274..628 CDD:278600 105/378 (28%)
DEXDc 300..492 CDD:238005 51/198 (26%)
DEAH box 463..466 2/2 (100%)
LXXLL motif 1 551..555 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 649..673 0/23 (0%)
Helicase_C 720..854 CDD:278689 47/133 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1120..1171 9/50 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1184..1221 4/16 (25%)
DEPP <1192..1278 CDD:291988 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1247..1284
LXXLL motif 2 1329..1333
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1445..1467
STH1NP_012140.1 HSA 314..382 CDD:400077 11/68 (16%)
PLN03142 370..>955 CDD:215601 196/772 (25%)
SnAC 1006..1069 CDD:405324 15/76 (20%)
COG5076 <1211..>1359 CDD:227408 19/96 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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