DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATG2A and Atg2

DIOPT Version :9

Sequence 1:XP_011543165.1 Gene:ATG2A / 23130 HGNCID:29028 Length:1940 Species:Homo sapiens
Sequence 2:NP_001261341.1 Gene:Atg2 / 38344 FlyBaseID:FBgn0044452 Length:1906 Species:Drosophila melanogaster


Alignment Length:2137 Identity:603/2137 - (28%)
Similarity:950/2137 - (44%) Gaps:439/2137 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     4 WLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMES 68
            |..||.. :|.::|||||..|||.||:.:|:|:||.:|||.|...:.||.|::.:.|::.|....
  Fly     3 WFNPWDG-LKTKMCRYLLQRYLGQFFENNLNLEQLKVDLYNGKAVVEDIFLKVNAFNDLFEDQGW 66

Human    69 PLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQ 133
            ..|:|.|.:|.:.|.|||.||:|:..::.:..|.:||:|......|....:|..|.:::|:|:|:
  Fly    67 AFEVVSGHIGRLTVVVPWNALMTNDSSLEIHNLTITLRPVTRYQSGTTMLESMWSSVSSSMQMAE 131

Human   134 ECLR---DGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDGERGVAVEVRV 195
            ||::   |.:|..:. ...|.|||.||:||:.||.||:....:|.:.:|:.....:|.:.:..:.
  Fly   132 ECMKQVDDDVPFLNH-NNALIGLEKFAETIDNVLNRIRAKLTNTTLNIEYILPRSDRKLVLSFQA 195

Human   196 QRLEYCD--------------EAVRDPSQA----PPVDVHQPPAFLHKLLQLAGVRLHYEEL--- 239
            ..:||.:              |...||:.:    |.:..|.        |.:.|:.||..|:   
  Fly   196 SHVEYKNKTGYEMPMSTSQDTETEEDPNSSFNALPMIAKHN--------LVIEGLSLHTSEVLDV 252

Human   240 ------PAQEEPPEPPLQIGSCSGYMELMVKLKQNEAFPGPKLEVAGQLGSLHLLLTPRQLQQLQ 298
                  |.   |.|...:|....|...:.:.:||.|...|||:.:...|..::.:|||||:..|.
  Fly   253 MDHQFGPT---PYEQLCKIVELKGAQNIQINIKQTENIVGPKVSLELSLDDIYFMLTPRQIHLLI 314

Human   299 ELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLDNTD 363
            |.....:.   .|..::..|.|.|                        .|..|....:.:|....
  Fly   315 EFSKGFNC---GGQQERPKKGRSL------------------------KSAPPSEYQMHSLQQPT 352

Human   364 LFFSMAGLTSSVASALSELSLSDVDL-ASSVRSDMA-SRRLSAQAHPAGKMAPNPLLD----TMR 422
            ....:.|..:...:.:||...|:..: .:..||..| ||::|...:.......|.|..    |.:
  Fly   353 RMTGILGQNADWCTGMSEADPSEYSVYGNPPRSGYARSRKMSESTNSMVTSCTNTLQQELGYTEK 417

Human   423 PDSLLKM-----TLGGVTL---TLLQTSAPSSGPPDLATH-FFTEFDATKDGPF-GSRDFHHLRP 477
            ...:||.     .:.|:.|   .|:|.:|.......:..| .:..:..|..|.| |:...:|:..
  Fly   418 SGEILKFKVQISKIYGIALHQDILIQNTANIDSCSTVFDHASYLRYSDTASGFFLGTLLENHIPL 482

Human   478 RFQ-----RACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYT 537
            :.|     ||.|   :.::|:..:...||.:     |||........:|||:       :..|: 
  Fly   483 QNQQYLLLRAAP---IIVSGSQQRYFQELTS-----RTTLSATAVDLIEVLD-------NSKEH- 531

Human   538 EILTFPGTLGSQASARPCA---HLRHTQILRR----VPKSRPRRSVACHCHSELALDLANFQADV 595
             :|.|.       ..|.|.   |:|...:|.:    :.|....|     |.:::...|....|::
  Fly   532 -LLQFD-------RQRNCPDGYHIRPEIVLTQSSSFMFKQNHNR-----CSNKIECSLDECTAEL 583

Human   596 ELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQQTVFRLSAPRATLRLRFPIADLRPEPD--- 657
            ::...|||.||...:....:..:   :.|.|....||.|.:.:....|.||||:.|.|...|   
  Fly   584 DISIYDRLGALFGSSPFSGDSAS---STPYPDDPNQTEFVVKSENLRLHLRFPVVDGRAANDPLK 645

Human   658 -PWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGK-PPVPCLRVSK 720
             ||..:.||.:.|.:|     |||.:.|.     .:.:.:...:|...|.|..| ..|..|:..:
  Fly   646 IPWWKKNVRRDFLAVE-----FRSLVVSS-----RSQISIVSDELDVFYCDADKQSAVHLLKCQQ 700

Human   721 ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYE 785
            .:.|                   :...|.:|       |:|...|..: ::...||||||.|...
  Fly   701 KMQP-------------------NKKIQIDV-------LQLKDTSDGQ-KKARKSPFSSKCTFGY 738

Human   786 TE------------EMVIPGDPEEMRTFQSRTLALSRCSLEVILPSVHIFLPSKEVYESIYNRIN 838
            |.            :.::||:.||:..|.......|:..:...:|.|.:.|.||.:||.||||:|
  Fly   739 TSHVEGLDGSVDKTDSLLPGETEEINEFCDSCTQSSKLKIFAFIPHVKVVLESKSMYELIYNRLN 803

Human   839 NDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDS---DSDD---- 896
            .||.||||.    :|.                               :|::||:   :|.|    
  Fly   804 GDLFMWEPR----SPH-------------------------------YDISPDNEVPESKDLYAE 833

Human   897 -----------------EDAHFFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETK 944
                             |.:.:||:..   |.|:||.||.:. ...||..:.|.:|.:.......
  Fly   834 PQLEEFRRNLLLSTSAMESSIYFSMAE---PTASAPPAPPVR-NEAFSFELFVEQGTLILFSHLL 894

Human   945 DEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLE-AEKATLYHRAAVDDYPLPSHLDL 1008
            |....:.....|:..::::...||:|:.........:|.:: .|...|:....:.|..| :..||
  Fly   895 DPETNQRSKECGKFQVNLKELRLFTVNGLDNDSTRSFFSIQLGEIDALHCGNTLQDLEL-AWSDL 958

Human  1009 PSFAPPAQLAPTIYPSEEGVTERGASGRKGQGR-GPHMLSTAVRIHLDPHKNVKEFLVTLRLHKA 1072
            ..    .:|.||||        ..||..:.|.| ...:||....|...|.:.:|...::..:..|
  Fly   959 AD----EKLLPTIY--------NFASVHQQQDRKRMEVLSLVAEIKKQPEQRIKRMKMSFGICGA 1011

Human  1073 TLRHYMALPEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAE 1137
            .|:|:....|.||.:||::|:||.|.|:..|.|..:::.|..|:::..:||||.:.|.|..:...
  Fly  1012 ILQHHSCHSEHSWLNQLIDFMDVADFPIEEYEPFALVSELQLHVWNAGIDYRPKFFPQRAFLDLG 1076

Human  1138 TFTLSSNIIMDTSTFLLRFILDDSALYLSDKCEVETLDLRRDYVCVLDVDLLELVIKTWKGSTEG 1202
            ..|||||||...|...||.:.:|..|.|. ..:.|:.|   ..:.||::.||.:   :::.:.||
  Fly  1077 YCTLSSNIISSMSGCTLRLLAEDCVLQLG-LVKEESND---SLIPVLNLGLLNI---SFRLNAEG 1134

Human  1203 KLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYVMSTGDLHPPPRP----------PSPTEIAG 1257
            . .||..:||.|.:.:|:.:|.||.|.|..|:.||.:..||.||..|          |.|.|   
  Fly  1135 S-GQPRVDLRSSIHDMHLKTCYDSAAALAQLIAYVANDRDLCPPEEPILNEDTKPAEPKPNE--- 1195

Human  1258 QKVQLSESPASLPSCPPVETALINQRDLADALLDTERS--LRELAQPSGGHLPQASPISVYLFPG 1320
             :.::|:...:..|           :.:|||::|.|.|  ||.:..|.|    :...|.::.||.
  Fly  1196 -EHEMSDHTQNHVS-----------KLMADAVIDVESSPNLRAMKSPGG----REEGIEIFYFPD 1244

Human  1321 E-------------RSGAPPPSPPVGG---------------------PAGSLGSCSEEK----E 1347
            |             .......||.|.|                     |..||||..:::    .
  Fly  1245 EPKEKRKSTSAKLQTKSLMVESPSVIGDILDFESNVILQSYYHQSQVQPQTSLGSQVQQELGSLG 1309

Human  1348 DEREEEGDGDTLDSDEFCILDAPGLGIPPRDGEPVVTQLH--PGPIVVRDGYFSRPIGSTDLLRA 1410
            :...||.|.|.:..:|...:|..|           |.|::  ..|:.:.|.:|..|....||||.
  Fly  1310 NASLEERDFDIIHDEEISRMDKFG-----------VKQIYISEDPLQIVDNHFELPHEKVDLLRP 1363

Human  1411 PAHFPVPSTRVVLREVSLVWHLYGGRDFGPHPGHRART------GLSGP-RSSPSRCSGPNRPQN 1468
            |::|||..:...|.|::..|||||||||...|..::.:      |:|.. :...|:....::...
  Fly  1364 PSNFPVAESTYTLCEMTFTWHLYGGRDFPDEPLKKSSSSATSGFGMSDTYKYGVSQAQEQDKQDK 1428

Human  1469 SWRTQG------GSGRQHHVLMEIQLSKVSFQHEVYPAEPATGPAAPSQELEERPLSRQVFIVQE 1527
            ....:|      ||.|...||:|:||||:.|.:|.||             |.....||||.:|.|
  Fly  1429 KGSKKGLLKQPKGSQRNLEVLVEMQLSKIRFSYETYP-------------LTSMYSSRQVLLVSE 1480

Human  1528 LEVRDRLASSQINKFLYLHTSERMPRRAHSNMLTIKALHVAPT-TNLGGPECCLRVSLMPLRLNV 1591
            :|:||||.||.||||||..|...:..:...||:.:|||:|.|. ......||.||||::|::||:
  Fly  1481 IEIRDRLRSSDINKFLYHPTGNNLSHKPDENMVIVKALNVRPNPQKSSAEECSLRVSILPIKLNI 1545

Human  1592 DQDALFFLKDFFTSLVAGINPVVPGETSAEARPETRAQPSSPLEGQAEGVETTGSQEAPGGGHSP 1656
            |||.|.||:|||:.:.         ..||.|...|:.:.||           :.:.:.|....|.
  Fly  1546 DQDTLLFLEDFFSGMF---------RNSASAAGGTKTEGSS-----------SSATDMPVMSVSK 1590

Human  1657 SP-------PDQQ------------------------------PIYFREFRFTSEVPIWLDYHGK 1684
            .|       ||.:                              |::|||..|:..:||..||||:
  Fly  1591 MPEELSDKLPDSEVKEMVERNLNVLIEENSLDVELEEDPATAPPVFFREVIFSPALPICFDYHGR 1655

Human  1685 HVTMDQVGTFAGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLGYALNEWLQDIRKNQLPGLLGG 1749
            .:.:.: |...||::|||||..|.:.|:.:..|.|:||.:|:..:...|||:||::||||.:|.|
  Fly  1656 RIELSR-GPVTGLIMGLAQLQGSGINLREIVNRRGILGWNKLCEFLAKEWLKDIKRNQLPNILSG 1719

Human  1750 VGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLMRGLQRGAASFGSSTASAALELSNRLVQAIQATA 1814
            :||.::|:|||||..||..||||||.||||::||.|.||.||.:.||.||||:::|::..:|.||
  Fly  1720 IGPTNAVLQLFQGIYDLFRLPIEQYNKDGRIIRGFQLGAQSFTARTALAALEITSRIIHLLQFTA 1784

Human  1815 ETVYDILSPAAPVSRSLQDKRSARRLRRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGH 1879
            ||.:|:|| |.|..:..:..|..:|.|:| :|.|||||||.||..|||||.::|.|:.:.|...|
  Fly  1785 ETTFDMLS-AGPSMKKRKGGRQGKRRRQG-RPKDLREGVANAYTIVREGINESANTLIEAAITEH 1847

Human  1880 EQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQIVPDAHKDHALKWRSD 1936
            :|||.:||||.|:||:|..||.|.:|||:||:::|||.::.::|:|..:...||:.:
  Fly  1848 DQKGYSGAVGAVVRQIPQLVVCPAVLATQATTNILGGAKSSLIPEAKLEARDKWKQE 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATG2AXP_011543165.1 Chorein_N 14..108 CDD:289396 37/93 (40%)
ATG_C 1841..1934 CDD:286423 46/92 (50%)
Atg2NP_001261341.1 Chorein_N 17..117 CDD:289396 37/99 (37%)
ATG_C 1814..1902 CDD:286423 44/87 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146020
Domainoid 1 1.000 528 1.000 Domainoid score I288
eggNOG 1 0.900 - - E1_KOG2993
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 711 1.000 Inparanoid score I650
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46464
OrthoDB 1 1.010 - - D18730at33208
OrthoFinder 1 1.000 - - FOG0002365
OrthoInspector 1 1.000 - - otm40464
orthoMCL 1 0.900 - - OOG6_102791
Panther 1 1.100 - - LDO PTHR13190
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R107
SonicParanoid 1 1.000 - - X1792
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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