Protein Alignment PLXND1 and plxnd1

DIOPT Version :10

• Sequence 1: NP_055918.3
• Gene: PLXND1 / 23129
• HGNCID: 9107
• Length: 1925
• Species: Homo sapiens
• Sequence 2: XP_002936302.3
• Gene: plxnd1 / 779491
• XenbaseID: XB-GENE-856537
• Length: 1867
• Species: Xenopus tropicalis
• Alignment Length: 1904
• Identity: 1205/1904 - (63%)
• Similarity: 1461/1904 - (76%)
• Gaps: 54/1904 - (2%)

Human    35 LLLLLGAARAGALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVP 99
            :|||...|.|..||:..:|.||..||||||....|.:|||||||||||:. .|..|.|...||||
 Frog     5 VLLLSLVALASGLELVSKFHSPQVTNNFALSAGEGLLYLAAVNRLYQLNW-ELRPELEDVTGPVP 68

Human   100 DSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFP 164
            ||||||||||.:.:|:.||..|.||||||..||.|||::.||||:||.|:||...||:..||.||
 Frog    69 DSPLCHAPQLRETTCDFPRTSTPNYNKILLPDPEQGLLLTCGSIFQGLCELRALRNITLRAVPFP 133

Human   165 PAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLLVGATYTGYGSSFFPRNRSLED 229
            ..       ...||||||||||||||||||:|  ...:|.::||||||||||.|.|||.|:|:.|
 Frog   134 VD-------NAVPSMLNVAANHPNASTVGLLL--RGPSGDTKLLVGATYTGYSSQFFPWNQSIAD 189

Human   230 HRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQ 294
            |||||:|||:||:|:.... .||||||::||||||.|:||..|.:|:||||.||   ...|
 Frog   190 HRFENSPEISIRALNLTAS-EKLFTFDISPSDDNIFKVKQSFKARHRLGFVRAF---QQGP---- 246

Human   295 SYAYLALNSEARAGDKESQARSLLARICLPHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLV 359
             :||||:|.|.....||::..|:||||||......:.:|||||||||||:|.|..  |.||.||:
 Frog   247 -FAYLAMNVEPAPAGKENRPSSVLARICLKSEPRTEPRKLTESYIQLGLRCEGPG--GVLYGRLL 308

Human   360 SVFPARERLFAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQ 424
            |||...|.:|.:||...        .||||.|....|...||.||..||.......|.|||||||
 Frog   309 SVFAESENIFGIFEGKN--------EAALCMFPLRSVAQEIRGARRGCFESQDAGEVTVLDSVVQ 365

Human   425 GTGPACERK-LNIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYTAVFLG 488
            ||||:|||: ..::||.||||||||||||||:|.:||.|.|:::..||||||||:|:.|..||||
 Frog   366 GTGPSCERRNAKVKLQEEQLDCGAAHLQHPLAITRPLPAVPIYKEKGLTSVAVANVSGYMVVFLG 430

Human   489 TVNGRLLKINLNESMQVV--SRRVVTVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVAACNV 551
            .|:|.|:||||:..|:::  |.:.:.:|.|:||||||:|||.|..||::||||||.|||||.|..
 Frog   431 NVSGHLIKINLDADMKIINKSMQYLEIASGQPVHHVMEFDPMDPTYLFVMTSHQMTRVKVAECAK 495

Human   552 HSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEG-PSRCPAMTVLPSEIDVRQE 615
            :.:|.:|:.|||||||||.||.||:||::|..|....||.|.:.| .:.||||..:|::||:...
 Frog   496 YRSCTECLAAADAYCGWCTLEGRCSLQKECQGSEDSAFWMSPNVGQENMCPAMNSIPNKIDISSS 560

Human   616 YPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAYCNLLPRDQFPPFPPNQDHVT 680
            ...:||||:|:||.|..|.::|||||||.|.|.:.......|:.:|:.|||||||.||||||:||
 Frog   561 TQRIILQITGNLPILYQMNVSCDYGNNIITPAVIDPDQDSGQLLHCSFLPRDQFPSFPPNQDYVT 625

Human   681 VEMSVRVNGRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHSCVSNQSRCEASPN 745
            |.|::.|.|.:|::..|.||||:||..::|..|||||:.::|||.||..||.|||:.|:| .:..
 Frog   626 VSMALSVGGNSIIQHKFIIYDCNRTQNMHPKNACTSCVKSRWPCSWCVSQHRCVSSASQC-GTIA 689

Human   746 PTSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWVNESVVRCDQ 810
            ..|.:.|||...:.|.|.|||.:::..:.|.||...:|..|||.||.|:.|.|.|:|.|.|.|..
 Frog   690 QNSTESCPRITATSLTPTPTGVTKDYTLSLLNTNITEGPKLECDFGTEQTFPAKWLNSSAVVCSN 754

Human   811 VVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSD-- 873
            |:|:|:.::|.||::|||......:||:|..::|.|||||..:||||.||||.||||.|.||:
 Frog   755 VLLYTSERTQSFPINLQLSDHKGLYLDNPSMLSVEVYNCASQTPDCSSCLGRADLGHHCSWSESS 819

Human   874 -GCRLRGPLQPMA--GTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACE 935
             .|||...:..::  .|||||:|..|:|.||||.||||:||:|||||.|.||:...|.||.:.|.
 Frog   820 MSCRLNSEILSISYPYTCPAPDIRKIDPASGPLLGGTLVTIQGRNLGSRFSDINGRVKIGEIECT 884

Human   936 PLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRIT 1000
            |:.::|.|||||||:||.:|..|:..|:|:.:..|:|::::|:.:|.|..|.|..||.|||||:|
 Frog   885 PIQEKYIVSEEIVCMTGESPKLLTDWVSVDVNGGGRSKEKYSFQVPEVDYLSPDFGPWAGGTRVT 949

Human  1001 IHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPE-GALP-APVPVCVRFERRGCVHGNLTF 1063
            |.|.:|::|.:::||.|.|..|.:|:||.::|.||:|. ..|| ..|.:||:||::.||...|.|
 Frog   950 ISGTNLNIGRDVRVLFNKTQECRDLVRTQSTIQCTVPPMKFLPETKVHICVQFEKKSCVKEELFF 1014

Human  1064 WYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTLCKVLNSTLITCPSPG 1128
            .|.:||||.::.||.||:||||.|||.||||.|||::.|.:.|.......|.||:.|:||||||.
 Frog  1015 KYQENPVIKSMDPRSSPLSGGRIITVTGERFDMVQSIMMGIQHEKGRRMNCTVLSPTIITCPSPT 1079

Human  1129 ALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGE 1193
            |.::....:||||||    .:|.:.:.:::       :.|.|:|.|:|.|.|||:||.||||.||
 Frog  1080 APNSTMENMDFFING----VQVDLGKAIVE-------AHFSLEYQPDPMFYTAKKEKLIKHHVGE 1133

Human  1194 PLTLVIHKEQDSLGLQSHEYRVKIGQVSCD-IQIVSDRIIHCSVNESLGAAVGQLPITIQVGNFN 1257
            |||||||||.|:|||:..|||||:||:.|: |.|.:|::||||:||||.::...||:|||||.||
 Frog  1134 PLTLVIHKEPDNLGLRVDEYRVKVGQIPCESIFIFNDKVIHCSINESLSSSQRYLPVTIQVGKFN 1198

Human  1258 QTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEI 1322
            |||.||.|.|.:|:||:||||||:|||||||||||||||||||||||||||:|||||||||||||
 Frog  1199 QTITTLHLAGIDTSIIISIVICSILLLLSVVALFVFCTKSRRAERYWQKTLVQMEEMESQIREEI 1263

Human  1323 RKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQ 1387
            |||||||||||||||||||||||||||||||||||||||||||||||||:||:|..|:|...|..
 Frog  1264 RKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYILPTQNFNTQLGFQVP 1328

Human  1388 ETHPLL-GEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIA 1451
            |||||| ||||:||:||.||||||:|.|:||||:|||:.|:||:|.||||||||||:|||.||||
 Frog  1329 ETHPLLCGEWKVPENCRTNMEEGITLLSTLLNNRHFLVTFIHAVELQKDFAVRDRCNLASHLTIA 1393

Human  1452 LHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFL 1516
            |||||||||||||:|||||||:||:||||||||||||||||||||||||||||||||||||||||
 Frog  1394 LHGKLEYYTSIMKDLLVDLIDSSASKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFL 1458

Human  1517 LLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLT 1581
            |||||||||||||||||||||||||:|||||||||||||.||||||||||||||.||.:||||::
 Frog  1459 LLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPMNLNVSFQGCGMDSLCVRVLDTDTVS 1523

Human  1582 QVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPE 1646
            |.|||||||||||:|||||||.|||||||||||::|||||||||:|::|||:||||||||||:.:
 Frog  1524 QCKEKILEAFCKNLPYSQWPRVEDVDLEWFASSSKSYILRDLDDSSIMEDGKKKLNTLAHYKVHD 1588

Human  1647 GASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSHRQSHRKKVLPEIYLTRLLSTK 1711
            ||||||||.||:|:||||||||||:||||||||||:|||.|:|||||||||||||||||||||||
 Frog  1589 GASLAMSLKDKRDDTLGRVKDLDTDKYFHLVLPTDDLAETKRSHRQSHRKKVLPEIYLTRLLSTK 1653

Human  1712 GTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNIL 1776
            |||||||||||:|||||.||:||||:|||||||||||||||||||||||||||||||||||||||
 Frog  1654 GTLQKFLDDLFRAILSIHEDRPPLAIKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNIL 1718

Human  1777 KNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQ 1841
            |||:||||:||:||:|||||||||||||||||||:||||||||||||||||||||||||||||::
 Frog  1719 KNPEFVFDMDKSDHMDACLSVIAQAFIDACSISDMQLGKDSPTNKLLYAKEIPEYRKIVQRYYQK 1783

Human  1842 IQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHK 1906
            |::|:||||||||||||||||||:|:|||||||||||||||:||.||:.|||.|||.:|.|||||
 Frog  1784 IKEMSPLSEQEMNAHLAEESRKYRNKFNTNVAMAEIYKYAKKYRTQIVTALETNPTTKRGQLQHK 1848

Human  1907 FEQVVALMEDNIYECYSEA 1925
            |:||:.||||:||.|.|||
 Frog  1849 FDQVIVLMEDDIYSCSSEA 1867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXND1	NP_055918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Sema_plexin_D1	49..547	CDD:200508	274/500 (55%)
		PSI	549..601	CDD:396154	24/52 (46%)
		TIG_plexin	<627..700	CDD:465588	36/72 (50%)
		PSI	711..753	CDD:214655	18/41 (44%)
		IPT_plexin_repeat1	891..979	CDD:238585	44/87 (51%)
		IPT_plexin_repeat2	981..1067	CDD:238584	40/87 (46%)
		IPT_plexin_repeat3	1069..1174	CDD:238586	44/104 (42%)
		Plexin_cytopl	1345..1883	CDD:462434	468/538 (87%)
plxnd1	XP_002936302.3	Sema_plexin_D1	19..491	CDD:200508	274/500 (55%)
		PSI	493..536	CDD:396154	22/42 (52%)
		TIG_plexin	552..645	CDD:465588	44/92 (48%)
		PSI	659..697	CDD:214655	17/38 (45%)
		TIG_2	708..791	CDD:465619	33/82 (40%)
		IPT	840..928	CDD:472823	44/87 (51%)
		IPT	930..1018	CDD:238050	40/87 (46%)
		IPT	1020..1114	CDD:472823	44/104 (42%)
		Plexin_cytopl	1286..1825	CDD:462434	468/538 (87%)