DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLXND1 and PlexB

DIOPT Version :10

Sequence 1:NP_055918.3 Gene:PLXND1 / 23129 HGNCID:9107 Length:1925 Species:Homo sapiens
Sequence 2:NP_524616.2 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster


Alignment Length:2127 Identity:633/2127 - (29%)
Similarity:990/2127 - (46%) Gaps:402/2127 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    47 LEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQ 111
            :|..|...|.....:.:.|.....::..|.|::.:|: .||.:.|||..||:.|||.|||...|:
  Fly    75 IESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLN-ENLRVLAEAVTGPLHDSPQCHAGGCPE 138

Human   112 ASCEHPRRLTDNYNKILQLD-PGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPP--AEPV 173
               :....|.:|:||||.:. ...|:::.||||.||.|::..       ..|| ||.|.  |.| 
  Fly   139 ---DIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYS-------LPRF-PATPQFFAVP- 191

Human   174 TVFPSMLNVAANHPNASTVGLVLPPA-AGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPE 237
                    :|||..||||...|.|.. |......|.||.|:|..|           |:| .:.|.
  Fly   192 --------LAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVG-----------DYR-HDVPA 236

Human   238 IAIRSLDTRGDLAKLFTFDLNPSD----DNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAY 298
            |:.|.||           |||.::    .:|:.|....::...:.::..|        .:..|||
  Fly   237 ISSRRLD-----------DLNYAEFSIQQSIINIDVKYRDHFLVDYIYGF--------NSSEYAY 282

Human   299 -LALNSEARAGDKESQARSLLARICL--PHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYS--RL 358
             :.:..::...| |:...:.|||||:  |:         .:||.::.:||.......| |:  |.
  Fly   283 FIIVQKKSHLAD-EAGYVTRLARICITDPN---------YDSYTEITVQCTATENNVD-YNIVRD 336

Human   359 VSVFPARERL----------------FAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTAC 407
            ..|.||..:|                |:........|.::   :|:|.:...|:..........|
  Fly   337 AKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESK---SAMCIYSIKDIEDMFIENIHLC 398

Human   408 FVEPAPD--VVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAP- 469
            |.....|  :..:..::..|..|......||.        ....:...:|.:.|:.|..:|... 
  Fly   399 FNGTTKDRNLGYISGTINDGRCPIVGSLGNIY--------NFCSVGLKISGVSPITAHALFHFDN 455

Human   470 -GLTSVAVASVNN--YTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSG 531
             .:|||...|..:  ::..||||..|.:.|:.|:.........:|..|....:.:.|.....|  
  Fly   456 VSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKD-- 518

Human   532 YLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEG 596
            :||:::..::.::::..|:|::.|..|:.:.|.:||||:||.|||::..|...:....|.|...|
  Fly   519 FLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSG 583

Human   597 PSRCPAMTVLPSEIDVRQ-EYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAY 660
            .......:::|.:|.:.: .:..:|::   :||.....:..|.:||:....|.:.....|     
  Fly   584 QQCIEFESIIPEKIPISELSHLHLIIR---TLPEPFNAKYRCVFGNSTPIDAEILENGLG----- 640

Human   661 CNLLPRDQFPPFPPNQDHVTVEMSVRVN--GRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWP 723
            |...|.|:.|..|.|.||:.|.:|||.:  .::.|..||..:|||.      |..|..||.:.|.
  Fly   641 CATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH------HGNCQECLQSSWG 699

Human   724 CFWCSQQHSCVSNQSRCEASPN--------PTSPQDCPRTLLSPLAPVPTG-GSQNILVPLANTA 779
            |.||...:.||....:|....|        |...::.|..||....|:... ..:|:..|.:..|
  Fly   700 CNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHA 764

Human   780 FFQGAALECSFGLEE---IFEAVWVNESVVRCD------QVVLHTTRKSQVFPLSLQLKGRPARF 835
            .|.     |:..:|.   :..|...:..:|.|:      ::..|..:...|...:.|      .:
  Fly   765 GFL-----CTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQ------HY 818

Human   836 LDSPEPMTVMVYNC-AMGS----PDCSQCLGREDLGHLCMW-SDGCRLR------------GPLQ 882
            :|:   ..|.:|.| .:||    ||||.|:.| |..:.|.| |:.|...            |...
  Fly   819 VDT---AIVTLYKCDVLGSHREHPDCSLCVTR-DPKYKCAWCSNSCVYNETCIADKNSISSGSKS 879

Human   883 PMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEI 947
            .:...||.|.|..|:|||||::||||:||.|.|||.|..||...::||.|.||  .:.|.:|.:|
  Fly   880 AIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LENYQISVKI 942

Human   948 VCVTGPAPGPLSGVVTVNASKEG--KSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGS 1010
            .|.||.:...:|..:.| |:..|  :|..:|.:...|:..|.||:||::|||::::.|..|::||
  Fly   943 ECRTGASLYEMSAPIKV-ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGS 1006

Human  1011 ELQVLVNDTDPCTELMRTDTS-IACTMPEGALPAPV---------------------------PV 1047
            .::..:::.:...::.:..:| ::||..|...|.|:                           |.
  Fly  1007 TMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPT 1071

Human  1048 CVRF--------ERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV 1104
            ...|        .|:.|    ..|.|.|:|.|..|.|.||..||||.:||.|...:.:|...:.|
  Fly  1072 RSNFGSYQLRSLPRQPC----SIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEV 1132

Human  1105 HHIGR--EPTLCKVLNSTLITCPSPGA-------------------------------------- 1129
            .:...  ..|.|.|:||..:.||||..                                      
  Fly  1133 FYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRK 1197

Human  1130 ------------LSNASAPVDFFINGRAYADEVAVAEE---------LLDPEEAQRG-------S 1166
                        .:||.:..::|:|............|         ::|..:..|.       .
  Fly  1198 KRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDI 1262

Human  1167 RFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRI 1231
            |..:.||.:|::.....: .:|.:.|:  :|||..|..:|....::..|.||...|:|..::...
  Fly  1263 RSTIVYLADPKYLPFPND-GVKLYKGD--SLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQ 1324

Human  1232 IHC-------------SVNESLGAAVGQLP-ITIQVG-NFNQTIATLQLGGSET-----AIIVSI 1276
            :.|             .|::|.     .|| :.::|| |....|..|:...::.     |::|.|
  Fly  1325 LLCIPPEQQPLPTDENGVDQST-----DLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGI 1384

Human  1277 VICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELN 1341
            :..::|:::.|:.|.:|..||.:|||.:::..:||..:||.:|.|.::.||||||||||||.:| 
  Fly  1385 LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADL- 1448

Human  1342 RSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPE-SCRPN 1405
            .|.|||.|::.:::.:.|||..|.                        ||:|...|..| |.:.|
  Fly  1449 ESTGIPTLDHVNYIMKVFFPGVSD------------------------HPILNSPKFREGSPQTN 1489

Human  1406 MEEGISLFSSLLNNKHFLIVFVHALE-QQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVD 1469
            .:..:..|..|:.||:||::|:..|| |:..|::|||.::|||:.:.|..|:||.|.|:|.||:.
  Fly  1490 YDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLR 1554

Human  1470 LIDAS-AAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAI 1533
            |||.| |:|:|:||||||||||||||||:::||||..|:|..|...|||..|||.||.||.:|||
  Fly  1555 LIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAI 1619

Human  1534 TGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYS 1598
            |..|||:||||.||.|.:......|:: .|....:.:..|..|.||::|||.|||:|..||.|:|
  Fly  1620 TNDARYSLSEERLLHEQVTHSVVILHI-LQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFS 1683

Human  1599 QWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNT-- 1661
            ..|...:|||||.........|:|.|.|:...:|.|:|||||||.:.|.|  .||||.::::.  
  Fly  1684 MRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESA--VMSLIARQNDNYH 1746

Human  1662 LGRVKDLDTEKYF----------HLVLPTD---ELAEPKKSHR---------------------- 1691
            :...|:.::..|.          |:::..|   .|.:|:..|.                      
  Fly  1747 IPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSP 1811

Human  1692 --QSH--------RKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEE 1746
              |||        ..|.:||:||||||:||||:|||:||.|..||::.|:.|| |||:.||.|:|
  Fly  1812 AFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPP-AVKWLFDLLDE 1875

Human  1747 QAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDL 1811
            .|.:..|:|.|.:|.||:|.||||||||.:|||.|:||::||..:|:|||||||.|:||||.|:.
  Fly  1876 AARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEH 1940

Human  1812 QLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAE 1876
            :||||||:||||:||:||.||.:|:.:|:.:..:..:|:|||:..:.:.|.:...||:|..|:.|
  Fly  1941 RLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKE 2005

Human  1877 IYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMEDNIYECYS 1923
            :|.|..:|:.|||.:||.:...|:..|..|...|.|.::.   :|.|
  Fly  2006 LYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDG---DCTS 2049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXND1NP_055918.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Sema_plexin_D1 49..547 CDD:200508 125/532 (23%)
PSI 549..601 CDD:396154 18/51 (35%)
TIG_plexin <627..700 CDD:465588 22/74 (30%)
PSI 711..753 CDD:214655 13/49 (27%)
IPT_plexin_repeat1 891..979 CDD:238585 38/89 (43%)
IPT_plexin_repeat2 981..1067 CDD:238584 25/121 (21%)
IPT_plexin_repeat3 1069..1174 CDD:238586 33/172 (19%)
Plexin_cytopl 1345..1883 CDD:462434 246/587 (42%)
PlexBNP_524616.2 Sema_plexin_like 86..534 CDD:200497 123/523 (24%)
PSI 535..586 CDD:396154 18/50 (36%)
TIG_plexin 594..682 CDD:465588 25/95 (26%)
PSI 683..730 CDD:214655 15/52 (29%)
TIG_2 738..827 CDD:465619 17/102 (17%)
PSI 836..877 CDD:214655 11/41 (27%)
IPT_plexin_repeat1 888..976 CDD:238585 38/90 (42%)
IPT_plexin_repeat2 977..1095 CDD:238584 25/121 (21%)
IPT_plexin_repeat3 1097..1211 CDD:238586 24/113 (21%)
TIG 1277..>1334 CDD:460355 13/59 (22%)
Plexin_cytopl 1452..2012 CDD:462434 246/587 (42%)
Blue background indicates that the domain is not in the aligned region.

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