Protein Alignment PLXND1 and plxnd1

DIOPT Version :10

• Sequence 1: NP_055918.3
• Gene: PLXND1 / 23129
• HGNCID: 9107
• Length: 1925
• Species: Homo sapiens
• Sequence 2: NP_991260.3
• Gene: plxnd1 / 402998
• ZFINID: ZDB-GENE-040426-1828
• Length: 1880
• Species: Danio rerio
• Alignment Length: 1925
• Identity: 1133/1925 - (58%)
• Similarity: 1390/1925 - (72%)
• Gaps: 66/1925 - (3%)

Human    21 PPFQTPPRCPVPLLLLLLLGAAR---AGALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQL 82
            ||.....|..:.||..|||.|.:   ||||.:|:.|.:|..|||||||.|:|.|||||||.||||
Zfish     2 PPSAADRRSALALLSALLLAALQTRSAGALHVQQAFATPGRTNNFALDAASGRVYLAAVNNLYQL 66

Human    83 SGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGF 147
            : |.|:||.|...|||.|:|||||||||||:|||.:.||||:||:|.||..|.:::.|||:||||
Zfish    67 N-ATLALEVEMRTGPVLDNPLCHAPQLPQATCEHQKTLTDNHNKLLALDRAQDVLLACGSVYQGF 130

Human   148 CQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLLVGAT 212
            |:|||..|:|.:||:|     |.:..||||||||:||||.||||||||.  ....|..|||||||
Zfish   131 CELRRLENVSRLAVQF-----PQDGATVFPSMLNIAANHENASTVGLVF--RTHGGSPRLLVGAT 188

Human   213 YTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTFDLNPSDDNILKIKQGAKEQHKL 277
            |||.|:.:||:|.|.||.|||||||||||:|||| :|.:|||:|:|||:||:.||||..|:::||
Zfish   189 YTGMGTEYFPKNHSKEDLRFENTPEIAIRALDTR-ELGRLFTYDINPSEDNVFKIKQEVKQKNKL 252

Human   278 GFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQARSLLARICLPHGA---GGDAKKLTESYI 339
            .||.||        ...:|:|:|.|::|.:|.||||..|:||||||...|   ..:::||||||.
Zfish   253 SFVHAF--------ALGNYSYIAFNNDANSGLKESQPNSVLARICLDTDAPRRAAESRKLTESYA 309

Human   340 QLGLQCAGGAGRGDLYSRLVSVFPARER----LFAVFERPQGSPAARAAPAALCAFRFADVRAAI 400
            |:||:|  ||     |:||:||.||..|    |||||.|..|.       ||:|.||.|:|...|
Zfish   310 QMGLRC--GA-----YTRLLSVSPAELRAETFLFAVFGRAGGR-------AAVCVFRVAEVEEMI 360

Human   401 RAARTACFVEPAPDVVAVLDSVVQGTGPACERK--LNIQLQPEQLDCGAAHLQHPLSILQPLKAT 463
            |..|..|...|..| |.|||||:||:|..||.|  :.:|||.:||:||||||||||::.:||:|.
Zfish   361 RQGRRNCSHGPNSD-VQVLDSVIQGSGAECEGKGSIMLQLQADQLNCGAAHLQHPLALRRPLRAR 424

Human   464 PVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPA 528
            |::.|.||:||||.|.:|:|.:|||: .|||.|::|:.:..|..:..:.:...|||||:|.|||:
Zfish   425 PLYEAQGLSSVAVDSAHNHTLMFLGS-RGRLHKVSLHSNFSVSQQWSLRLPANEPVHHIMTFDPS 488

Human   529 DSGYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSA 593
            |..|||:||||.:.||:|::|..:|:||||:.|.|.:||||.||.||::||||::.|....|.|.
Zfish   489 DRTYLYVMTSHHLLRVRVSSCEQYSSCGDCLSAGDPHCGWCTLERRCSVQQDCSSVSLSRSWISI 553

Human   594 SEGPSRCPAMTVLPSEIDVRQEYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQI 658
            |||..:||:||:.|:||....|...:.:.::||:|.|.|:.:.||||..|.|.|.|........|
Zfish   554 SEGVQQCPSMTITPAEISRSAEMRDVGILVAGSVPDLQGLRVECDYGMGISTNATVHLDYGTSHI 618

Human   659 AYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWP 723
            ..|.|.|....|..|...|||||.:|:..||.::|...|.||||.||.|::..||||||||:.|.
Zfish   619 QTCPLPPAHTLPTIPSGTDHVTVPVSINANGVSVVSGRFIIYDCERTGQIHSTTACTSCLSSAWR 683

Human   724 CFWCSQQHSCVSNQSRCEASPNPTSPQDCPRTLLSPLAPVPTGGSQNILVPLANTAFFQGAALEC 788
            |||..|.|.|||:::..:.....:|  .||..:...:.|:|||.|....:.|.|.|  .|.||||
Zfish   684 CFWDPQLHQCVSSKNNTQQLLQNSS--SCPSMVAYEVPPLPTGSSPVFSLELKNVA--HGTALEC 744

Human   789 SFGLEEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPARFLDSPEPMTVMVYNCAMGS 853
            .:...:.:.|.|::...|.|....|.||:.|:.|.|:|:..| .|.::|:|:.|||.||:|:.|.
Zfish   745 VYSDGQQYRAQWLDGPWVNCSGATLKTTQWSESFSLNLRRAG-DATYIDNPQRMTVEVYSCSAGV 808

Human   854 PDCSQCLGREDLGHLCMWSD-GCR--LRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRN 915
            .||||||||..||..|:|.: .||  ::.|....| .||||.||.||||||||.||||||:.|:|
Zfish   809 SDCSQCLGRAALGQECVWCEHSCRQQVQCPTTSSA-RCPAPLIHKIEPLSGPLTGGTLLTVTGKN 872

Human   916 LGRRLSDVAHGVWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLSGVVTVNASKE--GKSRDRFSY 978
            ||.|...::  |.||||.|..||.:||||..:||.||.:...:||.|||..:::  |.|:::||:
Zfish   873 LGHRADQLS--VSIGGVTCHTLPQQYTVSIRLVCETGASLEQMSGQVTVGVAEDAVGVSKEQFSF 935

Human   979 VLPLVHSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPA 1043
            |.|.:....|..||.||||.:||.|..|..||...:.:|:|..|:...|:...|.|.||..|...
Zfish   936 VEPRLLRFSPAQGPLAGGTTLTIQGQFLDAGSTTDIQINNTHTCSIRTRSSEIIRCVMPAAARAE 1000

Human  1044 PVPVCVRFERRGCVHG--NLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHH 1106
            .|.|||.|:.|.||..  |.||.|.:||.|:.|.|.||.:||||:|:|:|..|.:||:|.|.|..
Zfish  1001 NVSVCVVFDGRPCVSASPNFTFSYQKNPTISHIWPSRSYISGGRSISVSGVGFDLVQSVVMEVPG 1065

Human  1107 IGREPTLCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLD 1171
            :|:  |.|..::||||.|.||.|.......|.|.:||..|.|..:..   |:..|.....|:...
Zfish  1066 VGQ--TNCSCVSSTLILCQSPAADQAQQTAVLFSLNGVQYRDAASAG---LEEGEQPHTQRYSFQ 1125

Human  1172 YLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCSV 1236
            |:.:|||.||.:||.|||||||||.|:|:|....|.|...||.|.||...|||...:.::.|||:
Zfish  1126 YVEDPQFYTANKEKLIKHHPGEPLILIINKGPSDLDLTLDEYSVTIGSDLCDITFHNQQLFHCSI 1190

Human  1237 NESLGAAVGQLPITIQVGNFNQTIATLQL-GGSETAIIVSIVICSVLLLLSVVALFVFCTKSRRA 1300
            |.||.|:.|:||:|::||:|.:.||.:|: ||||.||:||||:|.|||||..|||.|:|||||||
Zfish  1191 NRSLSASTGELPVTVRVGHFQKVIAMVQMGGGSELAIVVSIVVCCVLLLLCTVALVVYCTKSRRA 1255

Human  1301 ERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSS 1365
            ||||||||:||||||||||:||||||||||||||||||||:|:|||||||||.|||||||||...
Zfish  1256 ERYWQKTLVQMEEMESQIRDEIRKGFAELQTDMTDLTKELSRTQGIPFLEYKQFVTRTFFPKMCC 1320

Human  1366 LYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKHFLIVFVHAL 1430
            .||.|.|.|....:..|.....||||||.:|:...|.|||:||||:|||:||||||||:.|||||
Zfish  1321 DYERRLVQPVYENDPLGPRAHSETHPLLQDWQPAGSVRPNLEEGITLFSTLLNNKHFLVTFVHAL 1385

Human  1431 EQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLT 1495
            |||:||||||||:|||||||||||||||||||||:||||||||||.|||||||||||||||||||
Zfish  1386 EQQRDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASATKNPKLMLRRTESVVEKMLT 1450

Human  1496 NWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLLRENIEAKPRNLNV 1560
            |||||||||.|:||||||||||||||||||||||||.:||||||||:|||||||||||||:|:.|
Zfish  1451 NWMSICMYSYLKETVGEPFFLLLCAIKQQINKGSIDVLTGKARYTLNEEWLLRENIEAKPQNVMV 1515

Human  1561 SFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYILRDLDD 1625
            ||||.||||:.||.|::||:.||||||||||.||:|||||||.|||:||||.....|.||:||||
Zfish  1516 SFQGLGMDSVCVRVMNSDTICQVKEKILEAFYKNLPYSQWPREEDVELEWFPEGRSSRILQDLDD 1580

Human  1626 TSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNTLGRVKDLDTEKYFHLVLPTDELAEPKKSH 1690
            :||:|||||||||:.||:||:||||||||.||::||||||||||||||.|||||.|||.|.:|:|
Zfish  1581 SSVMEDGRKKLNTVFHYQIPDGASLAMSLKDKRENTLGRVKDLDTEKYVHLVLPHDELMESRKTH 1645

Human  1691 RQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISD 1755
            |||.||||||||||||||||||||||||||||:||||:..:.||||:|||||||||||:||||:|
Zfish  1646 RQSQRKKVLPEIYLTRLLSTKGTLQKFLDDLFQAILSVPAENPPLAIKYFFDFLEEQADKRGITD 1710

Human  1756 PDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTN 1820
            ||||||||||||||||||||||||||||||:||||:||||||||||||||||:||||||||||||
Zfish  1711 PDTLHIWKTNSLPLRFWVNILKNPQFVFDIEKTDHMDACLSVIAQAFIDACSLSDLQLGKDSPTN 1775

Human  1821 KLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYR 1885
            |||||||||||:|.||.:|:|||::..|||||||.||||||||::|||||.:|:.|:||||||||
Zfish  1776 KLLYAKEIPEYKKRVQSFYRQIQELPALSEQEMNTHLAEESRKHRNEFNTTLALTEVYKYAKRYR 1840

Human  1886 PQIMAALEANPTARRTQLQHKFEQVVALMEDNIYECYSEA 1925
            .|:.:||::||||||||||||||||:||:|||||||.|||
Zfish  1841 AQVASALDSNPTARRTQLQHKFEQVIALVEDNIYECSSEA 1880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXND1	NP_055918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		1/1 (100%)
		Sema_plexin_D1	49..547	CDD:200508	274/506 (54%)
		PSI	549..601	CDD:396154	26/51 (51%)
		TIG_plexin	<627..700	CDD:465588	27/72 (38%)
		PSI	711..753	CDD:214655	18/41 (44%)
		IPT_plexin_repeat1	891..979	CDD:238585	47/89 (53%)
		IPT_plexin_repeat2	981..1067	CDD:238584	35/87 (40%)
		IPT_plexin_repeat3	1069..1174	CDD:238586	40/104 (38%)
		Plexin_cytopl	1345..1883	CDD:462434	429/537 (80%)
plxnd1	NP_991260.3	None