DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLXND1 and plx-1

DIOPT Version :10

Sequence 1:NP_055918.3 Gene:PLXND1 / 23129 HGNCID:9107 Length:1925 Species:Homo sapiens
Sequence 2:NP_001294554.1 Gene:plx-1 / 246019 WormBaseID:WBGene00004047 Length:1956 Species:Caenorhabditis elegans


Alignment Length:2115 Identity:590/2115 - (27%)
Similarity:947/2115 - (44%) Gaps:411/2115 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    30 PVPLLLLLLLGAARAGA-------LEIQRRFPSPTPTNN-----FALDGAAGTVYLAAVNRLYQL 82
            |..|...::.|.|.|.|       ::....|.:|:...:     .|:|.:...|::.|||.||.|
 Worm     2 PTFLQFFIIFGVAAAAAGSKNVYSIDDNLVFKNPSHDGHEVFEKMAIDPSTTRVFVGAVNSLYDL 66

Human    83 SGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVVCGSIYQGF 147
            :.|:|::......||..|||||...: .:..|.|....|:::.|.|.:......::.|.::|||.
 Worm    67 TSADLTVRRHVQTGPQDDSPLCRDAR-NREECRHQLSRTNSHTKALSVYDKSSKLIECSNLYQGR 130

Human   148 CQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSR------ 206
            |:||...|||.|      .:...||         ..:|..::|.|..|     |:|.:.      
 Worm   131 CRLRNLHNISEV------ISEAIEP---------RVSNDTSSSVVIFV-----GSGPANLSSEPV 175

Human   207 LLVGATYTGYGSSFFPRNRSLEDHRFENTPEIAIRSLDTRGDLAKLFTF-DLNPSDDNILKIKQG 270
            |.||||   .||.         ||     ..:::.||..|...|....| .|.......|..:..
 Worm   176 LYVGAT---IGSG---------DH-----DRMSVSSLFLRPQKAFEVVFPGLYGGTHVSLDYRSR 223

Human   271 AKEQHKLGFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQARSLLARICLPHGAGGDAKKLT 335
            ...::::.:::.|        .:..|||..........| :|..:|.|.|:|.     ||  |..
 Worm   224 GYYKYQIDYINGF--------ESGDYAYFVTRQRVNIAD-DSSIQSRLVRVCT-----GD--KNF 272

Human   336 ESYIQLGLQCAGGAGR----GDLY--------SRLVSVFPARERLFAVF----------ERPQGS 378
            .||.::.|:|......    .|:|        ::.:.:..:...|:.||          :.|.|.
 Worm   273 HSYTEVPLECTQNGVEFNLVQDVYVTRAGYELAKSLDISVSDPVLYGVFWEGDKNSYRSQEPTGK 337

Human   379 PAARAAPAALCAFRFADVRAAIRAARTACFVEPAPDVVAVLDSVVQGT----------------- 426
                   :|:|.|...::..:.:.....|:               :||                 
 Worm   338 -------SAICMFTMREIETSFKQNIMKCY---------------KGTSGLKKNLPWFSSNDDCR 380

Human   427 -------GPACERKLNIQLQPE-QLDCGAAHLQHPLSILQPLKATPVFRAPGLTSVAVASVNNYT 483
                   |..|.:.:|.::..: .:...|.::....|.|             ||::|:.:..:.|
 Worm   381 FTTLPWEGIKCGKDVNSKIGGDTPISTSATYVMEDSSNL-------------LTAIAINTTRSST 432

Human   484 AVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSGYLYLMTSHQMARVKVAA 548
            ..|:||..|:|.||.:.............:...||:...|:|. .|..::|::|..::.::..:.
 Worm   433 VAFVGTQGGQLHKILIESKRSAEKYATEMLTDNEPILSDMEFG-GDGKHVYILTPSKVIKMPTSR 496

Human   549 CNVHST-CGDCVGAADAYCGWCALETRCTLQQDCTNS--SQQHFWTSASEGPSRCPAM-TVLPSE 609
            |...|| |..|:.:.|.|||||.....||.::.|...  .....|.....  |:||.: :|.|.:
 Worm   497 CEALSTQCDTCLSSRDPYCGWCVSNNHCTQEESCEREVPHTSRGWLDFQN--SKCPRIRSVKPDQ 559

Human   610 IDVR-QEYPGMILQISGSLPSLSGMEMACDY----GNNIRTVARVPGPAFGHQIAYCNLLPRDQF 669
            |.:. .:|..:.::   :|.:..|..|.|.:    |:   .|...|.|..|.  ..|...|.::.
 Worm   560 IQINTADYLNVTIE---NLQAPKGRRMQCLFQFSTGD---AVVSDPMPFDGS--LKCATPPMNRL 616

Human   670 PPFPPNQDHVTVEMSVRVNGRNIVKA--NFTIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHS 732
            |..|.|:.|:..::.|..:|..:..|  ||:.|||:|      :|:|::|.::|:||.||.:.:.
 Worm   617 PRIPTNEYHLPAKLIVVSDGSKLPLATTNFSFYDCNR------YTSCSTCSASQFPCDWCLESNE 675

Human   733 CVS---NQSRC-----------EASPNPTSPQDCPRTLLSPLA--PVPTGGSQNILVPLANT-AF 780
            ||:   .:.:|           :.|.....|..||. :::|::  .|.||..:||.|.:.|. |.
 Worm   676 CVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKCPH-IVAPVSKMSVATGERRNISVKVENVDAT 739

Human   781 FQGAALECSFGL-----EEIFEAVWVNESVVRCDQVVLHTTRKSQVFPLSLQLKGRPA------- 833
            |.| ..:|.|..     |:|  |:..::..:.||:::..        |....|.|..:       
 Worm   740 FMG-DFKCEFKYGTVTHEKI--AMRTSDDTITCDEMLFE--------PYGTSLLGSGSTPYGFNV 793

Human   834 ---------------RFLDSPEPMTVMVYNCAMGSPDCSQCL----GREDLG-----------HL 868
                           |.||:...:.:.||:|...:.:|.:||    .:.|.|           |.
 Worm   794 IWSATGFAVGKKSINRVLDNVASLAIDVYSCENLATNCGRCLTLDADKYDCGWCSLDSKCARPHQ 858

Human   869 CM-------WSDGCRLRGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHG 926
            |.       |.:..:|          ||.|.|...:|..|.:.|||.:||.|.||||.:|||...
 Worm   859 CSNRQIPENWLNASQL----------CPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKA 913

Human   927 VWIGGVACEPLPDRYTVSEEIVCVTGPAPGPLS---GVVTVNASKE-----GKSRDRFSYVLPLV 983
            |.|..|.||.:  .|..|::||||||.:|...|   |||.|....:     ..|.:.||||.|:|
 Worm   914 VQIANVPCEVV--EYVPSQKIVCVTGKSPIKGSNERGVVAVTLRHDSLKFFAHSTEHFSYVQPVV 976

Human   984 HSLEPTMGPKAGGTRITIHGNDLHVGSELQVLVNDTDPCTELMRTDTSIACTMPEGALPAPVPVC 1048
            .|::|..||::|||.:|:.|.||..|:|:.|...... |..|.|....:.|.|.........|:.
 Worm   977 SSMKPVKGPRSGGTDVTLTGVDLDTGAEVTVRFGQIG-CKILERASGWLRCRMGASGEGGQFPLH 1040

Human  1049 VRFERRGCVHGNLT-------FWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAVHH 1106
            :.|:      |.|.       |.:..:|.:.:|||.::..|||.|:.|.|:.|.::|...|....
 Worm  1041 IAFD------GQLQNLPIPIYFEFTSDPSVQSISPNKTIPSGGITVDVYGQGFTLLQRPRMVFTG 1099

Human  1107 IGREPT---LCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEVAVAEELLDPEEAQRGSRF 1168
            :|.|.:   .|.:.:..::.|.:|.|....|          ....:..:.|...|.:.|:. .|.
 Worm  1100 LGDEKSYGPACSIEDDQMMKCATPTAPGKDS----------DRGSQERITEYAFDFDGAEL-YRS 1153

Human  1169 RLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIH 1233
            |:..:|:|.|.|....::::  |||.. |.::....:|.....:..||:|...|.:..::::::.
 Worm  1154 RIKVMPSPTFETLSEPRFVR--PGEDF-LTLNGNHLNLAASERDIDVKVGGEPCPLTALANKVLT 1215

Human  1234 CS--VNESLGAAVGQLPITIQVGNFNQTIATLQ-----LGGSETAIIVSIVICSVLLLLSVVALF 1291
            |.  |.:..||......|.:.|||.:.:|..:.     |..|...||:..:|..:.|::.::.| 
 Worm  1216 CQPPVKKPRGAGKLNPEIVVTVGNASFSIGEVSYDSPGLSSSLFFIIMFFIIFMIALIICLIVL- 1279

Human  1292 VFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELN-RSQGIPFLEYKHFV 1355
             :..||...:|..:....||:.:|.::..|.::.||||||.:...|.:|. .:...||||||.:.
 Worm  1280 -YRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSLNQYTADLPLGTPTAPFLEYKDYC 1343

Human  1356 TRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNK 1420
            .|..||                       .|.:.|.:|...::.......:|.|:..|..||.||
 Worm  1344 ARVLFP-----------------------NAGKNHAVLKNLEVDTHKAEAIEAGLREFHKLLMNK 1385

Human  1421 HFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAK--NPKLML 1483
            .||:..|..:|..|.|..:||..:.|||.:.|..|:.|.|.::|:||.:||:.:..|  .||::.
 Worm  1386 TFLLTMVRTMEANKYFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKFQPKILF 1450

Human  1484 RRTESVVEKMLTNWMSICMYSCLRE-TVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWLL 1547
            ||:||:.|:||..|.:..::..|:. ..|:..:.|...||||:.||..||:|.:|||:||||.||
 Worm  1451 RRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEEKLL 1515

Human  1548 RENIEAKPRNLNVSFQGCGMDS---LSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLE 1609
            |...|.|...:.||.......|   :.||.:|.||:||||||.|:|..:...::..|...|::||
 Worm  1516 RATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDMELE 1580

Human  1610 WFASSTQSYILRDLDDTSVVEDGR-KKLNTLAHYKIPEGASLAMS-------------------- 1653
            |.........|:|:|.:|.||.|. |:|||||||.:|..|.|.::                    
 Worm  1581 WKTGMNGKMALQDIDSSSRVEGGNWKRLNTLAHYNVPNNAILTLTSKSNSLYNLVNFSSTSMKTA 1645

Human  1654 --LIDKKDNTLGRVK-----------------------DLDTE---KYFHLVLPTDELAEPKKSH 1690
              |.|:.:.:...:|                       ..||:   |.:|||.||:.  .|..| 
 Worm  1646 SILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIADHASSSADTDNGFKLYHLVKPTEH--GPTDS- 1707

Human  1691 RQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISD 1755
                ::|::.||||||||..||||.||:..|.::|.|  ....|..:||.|||::|||.:.||:|
 Worm  1708 ----QEKMVTEIYLTRLLMMKGTLAKFITSLLESIFS--SSTVPPCIKYMFDFMDEQAREHGIND 1766

Human  1756 PDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTN 1820
            |:.:|.||:|:||||||||::|||.|:|||.|...|:.||||:||..:||||..|.||.||||::
 Worm  1767 PEVVHAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCLSVVAQTLMDACSTQDHQLTKDSPSS 1831

Human  1821 KLLYAKEIPEYRKIVQRYYKQIQDMTP-LSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRY 1884
            |||:||::.:||.:|..||.:| .||| :.:..|.|:|:.|||::..||:...|:.|:|||..:|
 Worm  1832 KLLFAKDMYQYRDLVDSYYTEI-SMTPRIDDATMGANLSAESRQHNGEFHVFSALNELYKYLDQY 1895

Human  1885 RPQIMAALEANPTARRTQLQHKFEQVVALMEDNIY 1919
            :..|:.|||:|..|:.::|..:.:.::||||.:.|
 Worm  1896 KESIIDALESNEHAQASRLPGRLQDLLALMESDYY 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXND1NP_055918.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Sema_plexin_D1 49..547 CDD:200508 114/556 (21%)
PSI 549..601 CDD:396154 16/54 (30%)
TIG_plexin <627..700 CDD:465588 20/78 (26%)
PSI 711..753 CDD:214655 13/55 (24%)
IPT_plexin_repeat1 891..979 CDD:238585 39/95 (41%)
IPT_plexin_repeat2 981..1067 CDD:238584 26/92 (28%)
IPT_plexin_repeat3 1069..1174 CDD:238586 25/107 (23%)
Plexin_cytopl 1345..1883 CDD:462434 222/593 (37%)
plx-1NP_001294554.1 Sema_plexin_like 42..495 CDD:200497 112/542 (21%)
PSI 496..550 CDD:396154 16/55 (29%)
TIG_plexin 556..649 CDD:465588 23/100 (23%)
PSI 650..>677 CDD:396154 11/32 (34%)
TIG_2 717..822 CDD:465619 23/115 (20%)
PSI 823..876 CDD:396154 10/62 (16%)
IPT_plexin_repeat1 878..973 CDD:238585 40/96 (42%)
IPT_PCSR 974..1059 CDD:238337 26/91 (29%)
IPT 1062..1146 CDD:472823 22/93 (24%)
IPT_PCSR 1179..1248 CDD:238337 15/68 (22%)
Plexin_cytopl 1333..1894 CDD:462434 222/593 (37%)
Blue background indicates that the domain is not in the aligned region.

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