Protein Alignment PLXND1 and plx-2

DIOPT Version :10

• Sequence 1: NP_055918.3
• Gene: PLXND1 / 23129
• HGNCID: 9107
• Length: 1925
• Species: Homo sapiens
• Sequence 2: NP_001364609.1
• Gene: plx-2 / 175101
• WormBaseID: WBGene00004048
• Length: 1785
• Species: Caenorhabditis elegans
• Alignment Length: 2027
• Identity: 544/2027 - (26%)
• Similarity: 873/2027 - (43%)
• Gaps: 379/2027 - (18%)

Human    17 AASPPPFQTPPRCPVPLLLLLLLGAARAGALEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQ 81
            |.:.|||:|.             |..       |:.|......::|.:.....|:|:|::|||..
 Worm    17 AVTQPPFETE-------------GVK-------QKLFHFSGHIDDFIVSRDQQTIYVASLNRLTS 61

Human    82 LSGANLSLEAEAAVGPVPDSPLCHAPQLPQASCEHPRR--LTDNYNKILQLDPGQGLVVVCGSIY 144
            ||.:|.|::.|.::|||.|||.|.|   ...||....|  .||...||||:.| ...::.|||:.
 Worm    62 LSISNFSIQHEVSLGPVQDSPWCSA---DGKSCLKDNRPFPTDVRTKILQILP-TNQILQCGSVK 122

Human   145 QGFCQLRRRGNISAVAVRFPPAAPPAEPVTVFPSMLNVAANHPNASTVGLVLPPAAGAGGSRLLV 209
            .|.|. .....:|.:.                .|.:.||||.|:||||..::       .:||:|
 Worm   123 LGSCS-TFNSKLSLIT----------------ESTIAVAANSPDASTVSKII-------DNRLIV 163

Human   210 GATYT---GYGSSFFPRNRSLEDHRFENTPEIAIRSL-----DTRGDLAKLFTFDLNPSDDNILK 266
            .|:.|   .|...|               |.:|||:|     :..|||.......|..:..|..|
 Worm   164 AASATKESPYRDPF---------------PAVAIRNLPGLNVENAGDLEGEAAVFLRAAYKNAFK 213

Human   267 IKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAYLALNSEARAGDKESQ--ARSLLARICLPHGAGG 329
            .......||.: ||.|.:.|                       :||:  ..:.|.|.|     ..
 Worm   214 FLYTFTHQHFV-FVVAMVTP-----------------------RESRLPMTTRLIRFC-----RN 249

Human   330 DAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPARERLFAVFERPQGSPAARAAPAALCAFRFA 394
            |.|  .|||.::.|||.|.....  |..|.::..:.::|.|.|.....||     .:::|.|...
 Worm   250 DTK--FESYSEIELQCRGEDNTN--YPFLNAIIQSYDKLIASFSTSSTSP-----KSSICVFSMQ 305

Human   395 DVRAA----IRAARTACFVEPAPDVVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLS 455
            .|:..    :...|:.......|.:         |....|..|.:|.|..:..:.|..   ..:.
 Worm   306 KVKLTFWYNVDRCRSGTDSIRLPHI---------GRDTKCVNKAHIPLDEDSCELGVG---GSIE 358

Human   456 ILQPLKATPVFRAPGLTSVAVASVNNYTAVFLGTVNGRLLKINLNE----SMQVVSRRVV-TVAY 515
            :::......:.:...|.:|      :..|:|.||...:::....:|    .::...|:.| ....
 Worm   359 LVEMSTKDIMGKVTSLMAV------DQKAIFAGTTTSQIVMFKWDEHHSNQLEEYGRKEVGDGRT 417

Human   516 GEPVHHVMQFDPADSGYLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQD 580
            |..|..:::|    ..::.:...:.:...:::.|:.||:|.:|:.:.|..|.||.....||....
 Worm   418 GSEVSKMVKF----GDFVIVQMPYGIILEELSTCSHHSSCTECLVSVDPLCQWCHPTQSCTTSAR 478

Human   581 CTNSSQQHFWTSASEGPSRCPAM--TVLPSEIDVRQEYPGMILQISGS---LPSLSGMEMACDYG 640
            ||           |...|:||.:  ..:||.:.|....|     ||.:   ||...|....|.:|
 Worm   479 CT-----------SPVTSQCPIVDGDPIPSIVSVNSSTP-----ISFNIHHLPPPVGFTYRCQFG 527

Human   641 NNIRTV--------ARVPGPAFGHQIAYCNLLPRDQFPPFPPNQDHVTVEMSVRVNGRNIVKANF 697
            .:..::        ...|...|                 ..||...:.:..|:..|  .|.:.||
 Worm   528 TSTSSIKANWTTTGVSCPSEIF-----------------TSPNTFEILLLTSISNN--PISRHNF 573

Human   698 TIYDCSRTAQVYPHTACTSCLSAQWPCFWCSQQHSCVSNQSRCEASPNPTSPQDCPRTLLSPL-A 761
            |:||||      .:..|:||:|:::.|.|||..|.|.::....|.|      :.|.:  :.|: .
 Worm   574 TVYDCS------GYGTCSSCMSSEYNCAWCSGLHKCSNSCGALEKS------KACVK--IQPMRL 624

Human   762 PVPTGGSQNILVPLANTAFFQGAALECSFGLEEIFEAVWVNESV---------VRCDQVVL---H 814
            |:..|..|.|::..:|        |:......|.|  ..|||.|         :||.::.|   :
 Worm   625 PIAIGSQQEIVLEASN--------LDTLDRRHEHF--CKVNEQVSLAKIASDSIRCGKIQLTLSN 679

Human   815 TTRKSQVFPLSLQLKGRPARFLDSP-EPMTVMVYNCAMGSPDCSQCLGREDLGHLCMWSD-GCRL 877
            ||..:.|.||||..:       ||. :...|.:|:|...:.|||.||.... ...|.|.: .|..
 Worm   680 TTSANMVVPLSLITR-------DSVIDIANVSLYSCTNLASDCSSCLALSP-SLSCGWCNRQCSH 736

Human   878 RGPLQPMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYT 942
            ..........|..|.|...||.|||::|||::.|.|.:||..:.||...:::.|..|..:  .|.
 Worm   737 ECHESKATAVCDPPRIDKFEPTSGPIEGGTIIKIYGNDLGMSVEDVRGKIYVAGSRCNIV--EYH 799

Human   943 VSEEIVCVT--GPAPGPLS---GVVTVNASKEGKSRDRFSYVLPLVHSLEPTMGPKAGGTRITIH 1002
            ||..|.|..  |.:.||:.   |..||..:   :|.:.:|:|...:.|..|..||.:||||||::
 Worm   800 VSNMIACQVDKGVSSGPIRISVGRATVAVA---ESSELYSFVRTSIFSAYPLYGPISGGTRITLY 861

Human  1003 GNDLHVGSELQVLVNDTDPC-TELMRTDTSIACTMPEGALPAPVPVCVRFERRGCVHGNLT---- 1062
            |.:|..||:..|.|... || .|.:.:.|.:.|..|.|..       :....|..||.:.:
 Worm   862 GQNLSSGSQTSVTVGGM-PCPIERVNSSTVLTCLTPSGTR-------IGKSARVVVHVDHSQTQL 918

Human  1063 ---FWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV-------HHIGREPTLCKVL 1117
               |.|..:|.|::|.|..|..:|||.:.|.|...:.||...:.:       .:|..:...|.::
 Worm   919 DQPFEYRSDPSISSIFPMTSFKAGGRIVYVQGNSLNTVQTAKLFLISSPTPPFYIISDLAPCHII 983

Human  1118 NSTLITCPSPGALSNAS-------APVDFFINGRAYADEVAVAEELLDPEEAQRGSRFRLDYLPN 1175
            ||||:||.:|..|...:       .||.|      :.|.|.....|        |.|.::...||
 Worm   984 NSTLMTCMTPKILETITRRVEYTRQPVGF------HMDNVTAVANL--------GRRIQMGIYPN 1034

Human  1176 PQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRIIHCS----- 1235
            |..|..   |.:::|.||. :|::.....:|..:.:::::.||...|.:.:|..|.:.||
 Worm  1035 PTLSPF---KGVRYHQGEQ-SLILEGHNLNLAAEPNDFKIFIGNERCYVTLVDVRQLVCSGPVRQ 1095

Human  1236 --VNESLGAAV-GQLP-ITIQVGNFNQTIATLQLGGSETAIIVSIVICSVLLLLSVVALFVFCT- 1295
              ..:..|..: |..| :|:.||:....:..::.........:|::|..:||.: ||.|.|.|.
 Worm  1096 PKATDERGIPINGDNPLVTVIVGSLRMELGLIEYSDHALPSRLSLLILGLLLFI-VVTLTVMCLV 1159

Human  1296 -KSRRAER--YWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNR-SQGIPFLEYKHFVT 1356
             |.||.||  .::|..||||.:|:.:|:|.::.||||||::....|..|. :.|...:.:.|||
 Worm  1160 FKRRRQEREKEYRKIQLQMENLENNVRKECKQAFAELQTNLVLSPKSANSVNLGPELINFPHFV- 1223

Human  1357 RTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPESCRPNMEEGISLFSSLLNNKH 1421
                        |..:.....|.|..|  ...|.|:.                ::.|.:||:.|.
 Worm  1224 ------------ENLLWSDNNLTSAPS--LARTLPVT----------------LAQFHALLSFKG 1258

Human  1422 FLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAA-----KNPKL 1481
            |:...|.|.|.....:..::..|||||...|.....|.|    |::|||:.|..|     |..:|
 Worm  1259 FIFTIVEAAESDVSISTSEKSMLASLLISVLLRNFSYCT----EVVVDLLRAHIARSVQNKRAEL 1319

Human  1482 MLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLSEEWL 1546
            :.|.::||||||.:.|||||:||.|...:.. :|.|..|::.|.:||.:||:||.||||::|..|
 Worm  1320 LFRNSDSVVEKMFSKWMSICLYSHLTPQMNS-YFYLYKALQYQTDKGPVDAVTGDARYTINEAKL 1383

Human  1547 LRENIEAKPRNLNV-SFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEW 1610
            |||:::.|...:.| .|:.|. :|:.:.....|.:.|||:|:..|..:..||||.||....:|::
 Worm  1384 LRESVDTKTLKIRVIPFEKCD-ESIDLEVHACDAICQVKQKVASAVYRETPYSQRPRITQFELKY 1447

Human  1611 FASSTQSYILRDLDDTSVVEDGR--KKLNTLAHYKIPEGASLAM------------SLIDKKD-- 1659
            .........|.|:.....:...:  .||.|||.|.|.:|.:|.|            ||.|...
 Worm  1448 KCPKRGDVKLTDVLPIETLSQKKLPVKLFTLADYGISDGCTLEMSPAVYTAESYRNSLADSGQSS 1512

Human  1660 -NTLGRVKDL-DTEKYFHLVLPTD-ELAEPKKSHRQSH-RKKVLPEIYLTRLLSTKGTLQKFLDD 1720
             ::|.|...: .:.||:||..|:. .:...|||...|: ..|.:||:||||||::|||::.:::|
 Worm  1513 WSSLDRCSPIYSSSKYYHLTNPSSGTMTFKKKSSNDSNLLPKSIPEVYLTRLLTSKGTVETYVED 1577

Human  1721 LFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDI 1785
            ..:::|.:.:...|..:|:|||.|:.:|...|:|: :....||.|...||.|.|.::|||.|||:
 Worm  1578 FLESVLYMHDSSYPPILKFFFDILDREASVNGVSE-NICQQWKANGYVLRVWANFVRNPQLVFDV 1641

Human  1786 DKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSE 1850
            ..:..:||.||.:||..:|..|.|:..||..||:::||:||::...|.:....:|::::..||..
 Worm  1642 PHSISMDANLSTVAQTMMDCFSFSEPVLGAHSPSSRLLFAKDVARLRPLSVDLFKRVKNSPPLGM 1706

Human  1851 QEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQV--VAL 1913
            .|:...|...:........:::|::|:..:.:....:|...|.:|....:.:|..|..||  |.|
 Worm  1707 DELRTELVNMANDVSTCKGSSLALSELLSWVRGNGIRISQLLSSNEQFSQQRLPQKLSQVLHVCL 1771

Human  1914 MEDN-IYECYSE 1924
            ..|| ||...|:
 Worm  1772 ETDNHIYSTISD 1783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXND1	NP_055918.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/5 (40%)
		Sema_plexin_D1	49..547	CDD:200508	116/518 (22%)
		PSI	549..601	CDD:396154	15/51 (29%)
		TIG_plexin	<627..700	CDD:465588	15/80 (19%)
		PSI	711..753	CDD:214655	12/41 (29%)
		IPT_plexin_repeat1	891..979	CDD:238585	31/92 (34%)
		IPT_plexin_repeat2	981..1067	CDD:238584	28/93 (30%)
		IPT_plexin_repeat3	1069..1174	CDD:238586	30/118 (25%)
		Plexin_cytopl	1345..1883	CDD:462434	173/563 (31%)
plx-2	NP_001364609.1	Sema	38..415	CDD:472829	111/475 (23%)
		PSI	447..488	CDD:214655	15/51 (29%)
		TIG_plexin	496..>546	CDD:465588	11/54 (20%)
		PSI	577..>615	CDD:396154	15/49 (31%)
		IPT_plexin_repeat1	750..839	CDD:238585	31/93 (33%)
		IPT_plexin_repeat2	841..925	CDD:238584	27/91 (30%)
		IPT	928..1017	CDD:472823	26/94 (28%)
		Plexin_cytopl	1213..1725	CDD:462434	171/549 (31%)