Protein Alignment POGZ and pogzb

DIOPT Version :10

• Sequence 1: NP_001397789.1
• Gene: POGZ / 23126
• HGNCID: 18801
• Length: 1417
• Species: Homo sapiens
• Sequence 2: NP_001333153.1
• Gene: pogzb / 561483
• ZFINID: ZDB-GENE-100609-3
• Length: 1924
• Species: Danio rerio
• Alignment Length: 2036
• Identity: 589/2036 - (28%)
• Similarity: 839/2036 - (41%)
• Gaps: 758/2036 - (37%)

Human    10 DTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSVSQQP--VSAPVPIAAHASVAGHL 72
            |:|||||||||||||||:             .|:|:....:.|..|  .|.|.|:   ..|....
Zfish     2 DSDLFMECEEEELEPWQQ-------------QSMDEPAGNAESSTPSVTSTPAPV---VDVPAPP 50

Human    73 STSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLVQQ------GGQPLILTQNPAP---GLGTMV 128
            .|....|.:...|:.:|    |.||.|......:|..      .|||:||    ||   ||||:.
Zfish    51 KTMVIPSLTSVVNAANT----VPLITNTITQRAVVPTEIPKAVQGQPVIL----APGGGGLGTVA 107

Human   129 TQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNVRPVQNAMNQVGIVLNVQQGQTVRPIT 193
            ...||.|...:.|..:       ||||:.||||.||:|::|.|..|:   :||||||||||||||
Zfish   108 LSQVLLPGTSIANVTN-------SQPIYFTTQGLPVQNIQPGQGPMS---LVLNVQQGQTVRPIT 162

Human   194 LVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTMPVR-PTTNTFTTV-IPATLTIRST---VPQSQS 253
            |:.|||||..||.:|..|:.:|...:|.|:.:..| .|.:||:|| ||||||.|:|   .|.:.|
Zfish   163 LLQAPGTQIFKPAIGATQIITQPAQIRAGAPVVNRAQTPSTFSTVQIPATLTFRTTNAVTPTAAS 227

Human   254 QQTKSTPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSIASFVTVKRPGVTG 318
                |.|..|:| |.||||              :||                ...||:|:    |
Zfish   228 ----SLPIVSST-TITQPT--------------RTT----------------TKIVTIKQ----G 253

Human   319 ENSNEVAKLVNTLNTI--PSLGQSPGPVVVSNNSSAHGSQRTSG-PESSMKVTSSIPVFDLQDG- 379
            ....::..|:|.:.::  |...|:...||:||.::.:|...:|. |..|..|..:||:.:....
Zfish   254 NGPLDMQNLMNLVKSVNLPGGAQAQTFVVMSNQNTKNGPVVSSAVPIISQNVIQTIPLPNATSST 318

Human   380 -GRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLDSEPSVPSAAKPP-SPEKTAPVAST 442
             ...:||||.||||:.||||||||:|||::|.       :....|.|:|.||| :|.|:|.|.
Zfish   319 TTTHLCPRCGAQFRMIEALRGHMCFCCPDLVH-------MTETSSTPTAVKPPATPPKSASVV-- 374

Human   443 PSSTPIPALSPPTKVPEPNENVGDAVQTKLIMLVDDFYYGR-DGGKVAQLTNFPKVATSFRCPHC 506
                      |..||..|....||: ..:|:|||||||||. :|.:|....:..|...||||..|
Zfish   375 ----------PSAKVDSPPSKTGDS-HPRLVMLVDDFYYGTFEGNRVYVPMDNSKEPLSFRCLTC 428

Human   507 TKRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKI 571
            :|:||||||.||||::||||||||||:|.||.||||:|:|.|||:||||||:||:..||:|||||
Zfish   429 SKKLKNNIRLMNHMRYHVELDQQNGEMDNHTSCQHCFRRFPTPFRLQCHLESVHTSIESSTKCKI 493

Human   572 CEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYCLKVFK 636
            |||:||:||:||||||::|||||||||||||:||||.||:|..|||..|||||||||.|||||||
Zfish   494 CEWSFENEPVFLQHMKNSHKPGEMPYVCQVCEYRSSFYSDVFNHFRTWHEDTRHLLCQYCLKVFK 558

Human   637 NGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPGTKVTIRASR 701
            :..::||||:||||..|||||||||||||.|||:|||:.||:|||||::|:||:|||||||||..
Zfish   559 HSTSYQQHYVRHQKSTVYHCNKCRLQFLFTKDKVEHKINHHRTFRKPRELDGLQPGTKVTIRAYV 623

Human   702 GQP---RTVPVSSNDTPPSALQEAAPLTSSMDPLPVFLYPPVQRSIQ----KRAVRKM------- 752
            |:.   ::...:|.:...:::..:...|.|.|          |:|.|    |:.|.||
Zfish   624 GKKTPGQSASKASTNIQKNSISSSQSTTLSGD----------QQSEQQQSGKKQVSKMFQFLSKF 678

Human   753 ----SVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALF 813
                :.:||..|:||:|:||||.||:|||||||||.|||||||||||||||||||.::||  ...
Zfish   679 QEQRAQLGRHKCVECTFDIPDFVNHYPTYVHCSLCFYSTCCSRAYANHMINNHVPGRAPK--PSK 741

Human   814 KNSVSGIKLACTSCTFVTSVGDAMAKHLVFNPSH------------------------------- 847
            |...|.:||.|..|.:.|..|:.|||||:..|.|
Zfish   742 KGPPSVVKLTCAGCEYSTPHGNLMAKHLIKFPDHSYCLFMRKECLETDIEFCHVEEEVEGPQGDE 806

Human   848 ---------------------------------------RSSSIL-------PRGL--------- 857
                                                   |:..:|       |..|
Zfish   807 ASDVGTQPDWLSLKQWNVPKEEGTVPEFMERCGPRHIMTRNHDVLDYFQVLFPDALFELIVCETN 871

Human   858 ----------------------------------------------TWIAH-SRHG--------- 866
                                                          ||..| .|:|
Zfish   872 AYATYCCSSGQGDTSWHPVSVQEIKGFFGLSILMGLQNLVEPDSYWTWEQHQGRYGSRTWELVYR 936

Human   867 -------------------------QTRDR---------VHDRNVKNMYPPPSFPTNKAATV--- 894
                                     |:.|:         :.:::::..|.|     ||..|:
Zfish   937 TMSVNRFKQISTYIRMSSMLVENDSQSADKLSFFQPMLSILEKSMQEAYSP-----NKCLTIDQA 996

Human   895 ------------KSAGATP----------------------AEPEELLTPLAPALPS-------- 917
                        ||..:.|                      .:.::|...:.|.|..
Zfish   997 FLPSHDKGTAQEKSKNSQPRIWLLCDSKSGFCHKLLVSTRQEKHKDLGKSVVPHLTEGLEGKHHN 1061

Human   918 ----------------------------PASTATP--------------------PP-------- 926
                                        |.|...|                    ||
Zfish  1062 IFLSSSLASVQLMKDLFDSGIYCSSSVLPQSAVLPKEFWDEPPLENPGNFKQYEFPPLLATRWKD 1126

Human   927 ----------------------TPT---------HPQALAL------------------------ 936
                                  :||         .|||..|
Zfish  1127 TKELVCLSTNANAGHEDVVWRRSPTKMGELYTIERPQAFKLLQDNMRGVDICNQLLTCNQLGGLD 1191

Human   937 -------------------------------PPLATEG----------------AECLN------ 948
                                           ||:...|                |:|..
Zfish  1192 LDTNWRRLFWFFVNLSIINSFIVLRETRKDNPPVWLPGGHFSQAVFRKRLGYQLAKCAERHTLQN 1256

Human   949 ----------------------------------------------------------------- 948
                                                                             
Zfish  1257 QIHNSMIEQQTVKKESQEVQEEVRHRLGKITRRARRCKVCNLKNMRHESMYGCTACHANLCKRSR 1321

Human   949 --------------------VDDQDEGSP--VTQEPELASGGGGSGGV----------------- 974
                                ||.:.:|:.  :..:.|:...|.....|
Zfish  1322 CFWEFHGFPTNYQGSAKVGFVDSKRDGTEPGLKHKTEMLERGQAKSSVDISNVSQGATAGQDEDV 1386

Human   975 -----------------------------------------------GKKEQLSVKKLRVVLFAL 992
                                                           .::|.|::.:.|::|.||
Zfish  1387 DQEMAPLEDEDTETDTDTVESSEEVPLRTVASEKEKRSLTKPTQPVRNREESLTIHQRRILLLAL 1451

Human   993 CCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLTQREQQLPVNEETL 1057
            |...::||:......:.|:.|::..:....|....  :..||.::|.:|||||||||.|:||..|
Zfish  1452 CAGIQKAAKEMDTKPQLIKTWIQDKEDQLNECCSS--ICGEAVDRLVQWVLTQREQQRPINEARL 1514

Human  1058 FQKATKIGRSLE--GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAENAGLFIDFVQRQIH 1120
            |:||:::.....  ..|:|||||||.||::|.|.......|...||..:.||...|.:.|..|:.
Zfish  1515 FEKASELQSQTNETSSFRISYEWAVNFMMQHKLGLDTCFTVQRELPSAMEENCRCFKELVHGQVK 1579

Human  1121 NQDLPLSMIVAIDEISLFLDTEVLSSDD--RKENALQTVGTGEPWCDVVLAILADGTVLPTLVFY 1183
            ..::|..:|..:|::|:|:|..:|:..:  |::.|:|..|:|:|:..:.||:||:||:||..:|.
Zfish  1580 TNNVPQCVIGVMDQLSVFVDINMLNEKNKVRRDTAIQFTGSGKPFVKIYLAMLANGTMLPAALFT 1644

Human  1184 RGQMDQPANMPDSILLEAKESGYSDDEIMELWSTRVWQKHTACQRSK-GMLVMDCHRTHLSEEVL 1247
            .......::.||::|:.|||.||...|.:|:|:|:||::|...|..| .:||:|.|....||.::
Zfish  1645 SHTTSTLSSTPDTVLIMAKEEGYKATEELEIWATKVWKQHLDSQNEKEALLVLDSHHCLTSESII 1709

Human  1248 AMLSASSTLPAVVPAGCSSKIQPLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWL 1312
            :.:|::.|....:||||:.:.|||::|::..::.....:|.:|.:|    :...:.|:||::.||
Zfish  1710 STVSSTKTFLPTIPAGCTCRHQPLEMCVRPVLQRLFLSRWAQQPKE----SVQPEDLMQLLVSWL 1770

Human  1313 GEVLGVIGDCPELVQRSFLVASVLPGPDGNINSP------------------------------- 1346
            .:.:......||.:|.||.:|.:||..:.:.:.|
Zfish  1771 DKAMSCFSSRPEFIQHSFCLAHLLPDQETHTDLPGTSVELLNILSEATLGPEVVDLESADEEEPM 1835

Human  1347 -TRNADMQEELIASLEEQ-------------------------LKLSGEHSESSTPRP-RSSPEE 1384
             |.:.|...|.|...|||                         |:::.|.::.|...| ..:|..
Zfish  1836 DTHSVDNVTEKIDLTEEQEDTENELNDDKAKNTEQQKETNDECLEIASESTDFSHSSPEHETPSH 1900

Human  1385 TIEPESLHQ--LFEGESETES 1403
            ..||:.|.:  |.....:|:|
Zfish  1901 NSEPDHLSESGLDANTDQTDS 1921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POGZ	NP_001397789.1	PLN02983	278..469	CDD:215533	57/196 (29%)
		C2H2 Zn finger	503..536	CDD:275371	24/32 (75%)
		C2H2 Zn finger	539..560	CDD:275368	15/20 (75%)
		C2H2 Zn finger	569..590	CDD:275368	16/20 (80%)
		C2H2 Zn finger	599..620	CDD:275368	14/20 (70%)
		C2H2 Zn finger	628..648	CDD:275368	12/19 (63%)
		CENPB	1028..1089	CDD:197828	30/62 (48%)
		DDE_3	1169..>1280	CDD:481203	41/111 (37%)
pogzb	NP_001333153.1	SP1-4_N	<25..315	CDD:425404	117/349 (34%)
		C2H2 Zn finger	425..458	CDD:275371	24/32 (75%)
		C2H2 Zn finger	461..478	CDD:275371	12/16 (75%)
		C2H2 Zn finger	491..512	CDD:275368	16/20 (80%)
		C2H2 Zn finger	521..542	CDD:275368	14/20 (70%)
		C2H2 Zn finger	550..570	CDD:275368	12/19 (63%)
		DDE_Tnp_1_7	852..1212	CDD:433521	31/364 (9%)
		HTH_Tnp_Tc5	1493..1547	CDD:472278	28/53 (53%)