Protein Alignment CLASP2 and chb

DIOPT Version :10

• Sequence 1: XP_047303710.1
• Gene: CLASP2 / 23122
• HGNCID: 17078
• Length: 1571
• Species: Homo sapiens
• Sequence 2: NP_524651.2
• Gene: chb / 43901
• FlyBaseID: FBgn0021760
• Length: 1491
• Species: Drosophila melanogaster
• Alignment Length: 1669
• Identity: 495/1669 - (29%)
• Similarity: 799/1669 - (47%)
• Gaps: 283/1669 - (16%)

Human     2 EPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRV 66
            :|..::.|..|:.:.|:..::|:.::|:.:| :....|.:..|:|.|   :|.|..|:..|::::
  Fly     5 KPSDLDGFIQQMPKADMRVKVQLAEDLVTFL-SDDTNSIVCTDMGFL---IDGLMPWLTGSHFKI 65

Human    67 SLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMD-QVAPPMYIWE 130
            :...||..|..:.||.:.|.:|.|.|:..:|||:||::|.||::||.|:..||: :|.||..:.:
  Fly    66 AQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALID 130

Human   131 QLA-SGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEI 194
            :|| |.|||||.:.||.....::..|:.:|.|.|.:...||.:|.|.||....||:|||..:|||
  Fly   131 KLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEI 195

Human   195 YRHVGEKVRMDLYKR-GIPPARLEMIFAKFDEVQSSGGMILSVCKDKS-----FDDEESVD-GNR 252
            |:|||:::|.||.:. .:|.::|.|:..|||:|:..|.::.|..|:.:     .|:.:::. ..|
  Fly   196 YKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRER 260

Human   253 PSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEGGAGAVDEDDFIKAFTDVPSIQIY 317
            |:           :....|.:||........|.|.   ...|.||||..:.|..:|..||.:.|:
  Fly   261 PT-----------RMIKRPLHSAVSSSLRPKPNVN---DVTGDAGAVTMESFESSFEVVPQLNIF 311

Human   318 SSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLS---- 378
            .::::::...::..|:||...||::|.:||||||:||:   ..|....|.:.:....|.||
  Fly   312 HAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLI---LSYHTQPQFVAVQLKELSLSFVDI 373

Human   379 -AKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHT 442
             .::|||||:||||||:|::|..|.||.|....:|:..|.||:.|||||:|::...|:::||::|
  Fly   374 LKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYT 438

Human   443 HVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARV 506
            |.|:|:.:.|.... |||..:|....|.:.||.:||||.:|||:|.||.:|:||.|.|||.:||.
  Fly   439 HAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARR 503

Human   507 EARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSG------SVASLPQSDRSSSSSQESL 565
            .:|..|...|.|||..|:.:|.:|:.:.|::|:...:..|      ...:.|::.|
  Fly   504 HSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPETRR--------- 559

Human   566 NRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQ------RSRSDIDVNAAAGAKAHHAAGQSV 624
                          ||        |:....||:||      ||.|.:|..||..||..  |..::
  Fly   560 --------------TV--------SRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVR--AQYTL 600

Human   625 RSGR---LGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSA-----PLAGMGNAKADSRGRS 681
            .|.:   ||....|..|          :.|.|:.....|.:|::     |....|:.....|||:
  Fly   601 YSRQRKPLGPNNSNQAS----------MTGAAASGSLPRPRLNSNSGGTPATTPGSVTPRPRGRA 655

Human   682 RTKMVSQSQRSSSPDKNEGSQSANTIGAGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASA--QK 744
            .   |||||                  .||||.||     :|.|.....|:......:..|  :|
  Fly   656 G---VSQSQ------------------PGSRSTSP-----STKLRDQYGGIGNYYRGATGAIPKK 694

Human   745 RSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRS 809
            .|.||||...|||.||:|   :....:.|...|.|.   .||.:....:|||   |.|:
  Fly   695 ASGIPRSTASSRETSPTR---SGGGLMKRSMYSTGA---GSRRTPERNNPVR---PSAA------ 744

Human   810 TGALYAPEVYGASGPGYGISQSSRLSSSVSAMRVLNTGSD--VEEAVADALLLGDIRTKKKPARR 872
                                 :..|:.|..|...|..|.|  .:....|.:..|.:|..:|
  Fly   745 ---------------------ARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRK---- 784

Human   873 RYESYGMHSDDDANSDASSACSERSYSS-------RNGSI---------PTYMRQTEDVAEVLNR 921
               ..|....||.:|:|||.|||||:.|       .|.|:         .|.....:|:..::..
  Fly   785 ---LMGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQF 846

Human   922 CASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVH 986
            |||::|||||:||:.|...|.:.:.|::.:||.:.::|.:||.|.|.| |:|:||:|:.:.|.||
  Fly   847 CASTHWSERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSLFLDTVTELILVH 910

Human   987 KDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLK 1051
            .::|.:|||:|||:|..|:|.|||.|:.:|:.|.|.|..|.||..||...|.|...|.||||:.|
  Fly   911 ANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTK 975

Human  1052 TVKPALRDQLHSFWSSKVKVAILKYIETLA----KQMD-PGDFINSSETRLAVSRVITWTTEPKS 1111
            |                 ::|||:::..||    |..| |.|  .|......|.::.....:.||
  Fly   976 T-----------------RIAILRFLTDLANTYCKSSDFPSD--QSQACERTVLKLAQLAADQKS 1021

Human  1112 SDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLR----NTGNGTQSSMGSPLT 1172
            .::|..|:|.|::|:.||||:.|:||..|||.:||.|...:|:|:|    :..:|..|...|||:
  Fly  1022 MELRSQARSCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLS 1086

Human  1173 RPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMN 1237
            ..:|:       ||.||:.....:|..........:.:.....||:.      |...|.|:.|:.
  Fly  1087 SSSPK-------PLQSPSVGPFASLQSHHHQLSISSTSPRSRQSSVE------QELLFSSELDIQ 1138

Human  1238 EPLKRDSKKDDGDSMCGG----PGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNP 1298
            ..:::.|::   ...|.|    ..::.....|......|...|:.|||..:..|.||..:...|
  Fly  1139 HNIQKTSEE---IRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSN- 1199

Human  1299 YNYSDSISPFNKSALKEAMFDDDADQFPDDLSL--------DHSDLVAELLKELSNHNERVEERK 1355
               :...:......|:......:|....||..:        ::.:|:      |:::....|..:
  Fly  1200 ---TPESATMRLDNLERERTTQNAKSPTDDAKVITVSINMAENGELI------LASNLMESEVVR 1255

Human  1356 IALYELMKLTQEESFSVW-------------------DEHFKTILLLLLETLGDKEPTIRALALK 1401
            :||    .||:::...:.                   ::||::|:.:||..|..:...:....|.
  Fly  1256 VAL----TLTKDQPVELLQTSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLH 1316

Human  1402 VLREILRHQPAR--FKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPII 1464
            ||.:|:|....|  :.::.||.::|.::.::. .||.:|..:.....:|.|:..:..|.::.|:|
  Fly  1317 VLSKIMRSNKMRHNWMHFLELILLKIIQCYQH-SKEALRDIDSMIPRIAPSLPLDLSINIVNPVI 1380

Human  1465 QTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIG 1529
            .|.::|.||.|||:..:|.|....|..:..|..:.|.|.:..|:::|.||||.|||:|.::.|:|
  Fly  1381 ATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLG 1445

Human  1530 DE-LKPHLSQLTGSKMKLLNLYI-KRAQTGSGGADPTTDVSGQS 1571
            :| :||.||.|..||::|||:|| |:....|||...|.:.|..|
  Fly  1446 EEKVKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSSTKNSSAAS 1489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLASP2	XP_047303710.1	HEAT repeat	131..157	CDD:293787	11/26 (42%)
		HEAT repeat	167..201	CDD:293787	18/33 (55%)
		HEAT	168..198	CDD:460773	15/29 (52%)
		CLASP_N	327..539	CDD:432496	90/217 (41%)
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	8/30 (27%)
		HEAT	88..>195	CDD:441023	44/106 (42%)
		HEAT repeat	90..120	CDD:293787	14/29 (48%)
		HEAT repeat	131..154	CDD:293787	10/22 (45%)
		HEAT repeat	165..195	CDD:293787	12/29 (41%)
		CLASP_N	316..536	CDD:432496	90/222 (41%)
		PHA03307	568..>746	CDD:223039	64/251 (25%)