Protein Alignment ATP10B and ATP8B

DIOPT Version :9

• Sequence 1: NP_001353581.1
• Gene: ATP10B / 23120
• HGNCID: 13543
• Length: 1461
• Species: Homo sapiens
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1648
• Identity: 504/1648 - (30%)
• Similarity: 776/1648 - (47%)
• Gaps: 342/1648 - (20%)

Human    14 WRVRDGFPHCPSETTP----LLSPEKGRQSYNLTQ-QRVVFPNNSIFHQDWEEVSRRYPGNRTCT 73
            ::.||......|::.|    |....:.|.||..:: :|.:..|:..|:..:     :|..|...|
  Fly   157 YKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQF-----KYHNNYIKT 216

Human    74 TKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDF 138
            :||:||||||.||.|||.|.||.|||.|::|..:|::.......|.:||..||.:..:||..:|.
  Fly   217 SKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI 281

Human   139 KRHRFDKAINCSNIRIYERKEQT-----YVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNG 198
            :||..|..:|       .||.:|     .|:..|.:|:|||.|::..|:.|.||.|||.:|:|||
  Fly   282 QRHISDSQVN-------NRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNG 339

Human   199 ICHLETASLDGETNLK-QRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRT 262
            :|.:|||.|||||||| ::|:.:.....:.......|:..|:||:|||.||||.|.:....| |.
  Fly   340 LCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RF 403

Human   263 GFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGI---L 324
            ....|.:|||||.:|||:...|:|::||.:||.|.|:...::|.:.::|.:|   |..|||   |
  Fly   404 ALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGIVLFL 465

Human   325 ILMCLIGAVGHSIWNGTFEEHPPFDVPDAN---GSFLP--SALGGFYMFLTMIILLQVLIPISLY 384
            :.:|.:.|:|.:||.|...:|....:|..:   ..::|  :.:.|..:|.:..|:|..::|||||
  Fly   466 VSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLY 530

Human   385 VSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCT 449
            ||:|:::..|.|.::.|.::|...|:...:.|...:.|:||||||||||||||||:|.|.|.:|:
  Fly   531 VSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCS 595

Human   450 IMGSEYSHQENAKRLETPKELDSDGE--EWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSAR 512
            |.|..|.   :...|.|       ||  |.|:.|.:..::.....|:.:.....|.|     :|.
  Fly   596 INGRSYG---DVIDLRT-------GELVEITEQQTIFQNSNTNNRPSPLSGAIVAPP-----AAP 645

Human   513 VPI------QGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPA- 570
            .||      :.|.::.||          ..:||.|..|.||:......|.|...  ..|:.||.
  Fly   646 PPIILVHKAEVHAKKTSM----------VVTSSGEAQVLPDRPRSDIERSAPPM--DASEKRPGL 698

Human   571 ----------------------------------------------------KASLSTTSSIADF 583
                                                                :..||.|||
  Fly   699 KHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSS---- 759

Human   584 FLALTICNSVMV---STTTEP---------RQR-VTIK----PSSKALGTSLEKIQQLFQKLKLL 631
                  |:.|.:   |..||.         |:| |.|:    ||:..||.   .|.||...|...
  Fly   760 ------CDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGV---VISQLEHHLDEE 815

Human   632 SLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSG 696
            ..|.|..||........::...|.:::........||....:...:..:|   |....:|::...
  Fly   816 PQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFR---WYDRTLLDAVRS 877

Human   697 ----------------TSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQ 745
                            |.:.|.::.        :..|:|:||||||||.||..:.|...:|||..
  Fly   878 DEEHSHVFFRLLALCHTVMAETVDG--------KLEYQAQSPDEAALVSAARNFGFVFRTRTPNS 934

Human   746 VTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGE-IVVYTKGADSVIMDLL----EDPAC 805
            :|:.: .|....:.||..|.|::|||||||::|.   |: :|:|.||||:||.|.|    ||
  Fly   935 ITIEV-MGQTEEYELLNILDFNNVRKRMSVILRR---GDSMVLYCKGADNVIYDRLHGGQED--- 992

Human   806 VPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELL 870
                        ::||||.||:.:|.:|||||.:|::.::|:.:..|.|.::||..|:|:|::.|
  Fly   993 ------------LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL 1045

Human   871 METAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLL-NQ 934
            ....:.:|:::.|:|.|.|||:||:|||.:||.|:.|||::|||||||||||:||.:||:|| ::
  Fly  1046 NAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDE 1110

Human   935 TDTVYTINTENQETCESILNCALEELKQFRELQK------------------------------- 968
            ...|:.::..:.|..|       ::|:||:|..|
  Fly  1111 LADVFIVDGNSVEEVE-------KQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQ 1168

Human   969 -------------------------------------PD----RKLFGFRLPSKTPSITSEAVVP 992
                                                 ||    ..|||....|:.....|..|..
  Fly  1169 TSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDE 1233

Human   993 EAG--LVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGD 1055
            ..|  ||::|.:|......:||.|||::...|::|:|||.|||||:::|:|::.....:||:|||
  Fly  1234 NTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGD 1298

Human  1056 GANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKN 1120
            ||||||||:||.||:|||||||:|||:|||::|.:|::|::||||||.|.|.|:.:.:.|:.|||
  Fly  1299 GANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKN 1363

Human  1121 VCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQ 1185
            ..:.....||..|||||:.|:.|...:..:|||:||||.|..||.::|:|.:..|..|.||..|.
  Fly  1364 FAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGL 1428

Human  1186 NSECYNLSTFWISMVDAFYQSLICFFIPYLAYK------GSDI-DVFTFGTPINTISLTTILLHQ 1243
            .||.:|:..|..|::...:.||:.|.|||..||      |..: |..|.|..:.||.:.......
  Fly  1429 KSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQI 1493

Human  1244 AMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNP----TFYLVCFL 1304
            ::....||:.:.|.:.||.:.||::...||...      ..||   .|.|:..    ||::...:
  Fly  1494 SLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVI------GGPY---VGSLTQAMKDLTFWVTMLI 1549

Human  1305 TPVVALLP----RYFFLSLQGTCGKSLISKA-QKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARP 1364
            |.:..:.|    :::.|.:..:....:..|: :||.............|.|.|:........|..
  Fly  1550 TVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQ 1614

Human  1365 -------THHPVSSITGQDFS----ASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSG-DS 1417
                   |...:.....|||:    ..|.|:           .|||...        :|..| :|
  Fly  1615 EGFGRLITSGKIMHKLPQDFAFPLGLGTKKT-----------QVLHNNL--------NSADGPNS 1660

Human  1418 SAQLSSGEHLLGPNRIMAYSRGQ 1440
            .....:|.|::..|..|.:::.|
  Fly  1661 KGNNVTGHHMVNNNTNMRHNQNQ 1683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	439/1332 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..541		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..687		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1346..1397		10/61 (16%)
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	27/69 (39%)
		Cation_ATPase	891..985	CDD:289987	41/105 (39%)
		HAD_like	<1261..1324	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	83/255 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830