DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HIC2 and CG6654

DIOPT Version :9

Sequence 1:NP_055909.2 Gene:HIC2 / 23119 HGNCID:18595 Length:615 Species:Homo sapiens
Sequence 2:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster


Alignment Length:572 Identity:125/572 - (21%)
Similarity:180/572 - (31%) Gaps:223/572 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   230 CSSST-------NGSSGGCEQELGLDLSKKSPP-------------------------------- 255
            |.|||       :|.||.|..::..:.:|..|.                                
  Fly    10 CLSSTGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSR 74

Human   256 -----LPPATPG----------PHLTPD-------------------DAAQLSDSQHGSPPAASA 286
                 ||.|.|.          |..|.|                   ||...:|::..:....|.
  Fly    75 TLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKST 139

Human   287 PPVANSASYSELGGT-----PDEPMD---------------------------LEGAEDNH---- 315
              ::....|...|..     ||||::                           .||  |:|    
  Fly   140 --ISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEG--DDHELEQ 200

Human   316 ------LSLLE------------APGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCP 362
                  |::.|            ||....|||......::|..|.:...||..|.||...     
  Fly   201 QIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEK----- 260

Human   363 GEEGEGVGDRVP---------NGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGG- 417
                    ::||         .|::......:.|....|.|  ::...|......:.::|:..| 
  Fly   261 --------EQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSP--KQHRLGTQRKLSAPRAGTVNGP 315

Human   418 ---SGHASAHYM--------------------YRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNA 459
               ||.|:...:                    .||:|..     :..|.|..|.|.|.|.:.|..
  Fly   316 STTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCI-----NRNYKCNECEKVFVSPDHLAE 375

Human   460 HVETHTEEELFIKEEGAYETGSGGAE-EEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQH 523
            |..:|          ||:.....|.. :..|.||.............:|::|:|.:...:|||.|
  Fly   376 HQASH----------GAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDH 430

Human   524 EKTHWLTRPFPCNICGKMFTQ----------------------------RGTMTRHMRSHLGLKP 560
            .:.|...:||.||||||.|||                            :..:|.|.|:|.|.||
  Fly   431 MRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKP 495

Human   561 FACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHT 612
            |.|:.|..|||....|.:|.|.|:||:||.|.||..:||....|.:|.|.||
  Fly   496 FECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHT 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HIC2NP_055909.2 BTB 40..140 CDD:279045
BTB 47..141 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..208
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..421 56/330 (17%)
Binding to CtBP 246..250 0/3 (0%)
TMEM119 <300..395 CDD:292352 27/157 (17%)
C2H2 Zn finger 444..464 CDD:275368 7/19 (37%)
zf-C2H2 505..527 CDD:278523 7/21 (33%)
C2H2 Zn finger 507..527 CDD:275368 7/19 (37%)
zf-C2H2 533..555 CDD:278523 13/49 (27%)
C2H2 Zn finger 535..555 CDD:275368 12/47 (26%)
zf-H2C2_2 548..572 CDD:290200 12/23 (52%)
COG5048 559..>613 CDD:227381 26/54 (48%)
C2H2 Zn finger 563..583 CDD:275368 8/19 (42%)
zf-H2C2_2 576..600 CDD:290200 12/23 (52%)
C2H2 Zn finger 591..611 CDD:275368 8/19 (42%)
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 10/68 (15%)
C2H2 Zn finger 331..354 CDD:275368 3/22 (14%)
COG5048 <357..570 CDD:227381 65/201 (32%)
C2H2 Zn finger 360..380 CDD:275368 7/19 (37%)
C2H2 Zn finger 385..406 CDD:275370 4/20 (20%)
C2H2 Zn finger 414..434 CDD:275368 7/19 (37%)
zf-H2C2_2 427..451 CDD:290200 13/23 (57%)
C2H2 Zn finger 442..490 CDD:275368 12/47 (26%)
C2H2 Zn finger 470..487 CDD:275368 1/16 (6%)
zf-H2C2_2 482..507 CDD:290200 12/24 (50%)
C2H2 Zn finger 498..518 CDD:275368 8/19 (42%)
zf-H2C2_2 510..534 CDD:290200 11/23 (48%)
C2H2 Zn finger 526..546 CDD:275368 8/19 (42%)
zf-H2C2_2 539..563 CDD:290200 5/9 (56%)
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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