DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HIC2 and CG10321

DIOPT Version :9

Sequence 1:	NP_055909.2	Gene:	HIC2 / 23119	HGNCID:	18595	Length:	615	Species:	Homo sapiens
Sequence 2:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	121/651 - (18%)
Similarity:	212/651 - (32%)	Gaps:	207/651 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   104 KLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRP---PRSQRL 165
            :|:....|.:|   |:......:.:|.|.....:.|..||        .:|.|.:.   |..|.:
  Fly   180 QLMQEHAPQQP---TMQQQIQQIHMPTLQPAPAQLLSAAG--------ATTTMPQQILLPNGQLI 233

Human   166 STASVIQARY--------QGLVDGRKGAHAPQELPQ----AKGSDDELFLGGSNQDSVQGL---- 214
            :||.::..:.        |...:|:..|...|.|||    ..|...::....:...::|.:
  Fly   234 TTAQIVAPQLAQIISTAPQSTTNGQATAAQSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQLVP 298

Human   215 GRAVCPAGGEAGLGGCSSSTN--------GSS----------GGCEQE----------------- 244
            .|::.|    .|:...:::||        |:|          .|||.|
  Fly   299 QRSLAP----TGVTTVTTTTNATDMGQHVGASLGDADVQLLEDGCEVEDEELEDVYEQLDSKADH 359

Human   245 ----LGLDLSKK---------------SPPLPPATPGPHLTPDDAAQ------LSDSQHGSPPAA 284
                :.||..::               :..|..:....|...||..|      :.|.:....|..
  Fly   360 SFETIVLDDDQQQDFLKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEE 424

Human   285 SAPPVANSASYSELGGTPDEPMD---------------------LEGAEDNHL--SLLEAPGGQP 326
            .    .::....|:....||.:|                     |.|..|:.|  |::|.|.|:.
  Fly   425 D----QDTFIIEEIQLEDDEMLDDPDGEEIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGET 485

Human   327 RKSL---------RHSTRKKEWGKKEPVAGSPFERREA--------GP------KGPCPGEEGEG 368
            ...:         .|..:.:|..:...:..:..|..:|        ||      ..|.| :..:.
  Fly   486 SVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTP-KRAKR 549

Human   369 VGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDS---AQSGSEGGSGHASAHY----- 425
            ...::|.|:...      |....| |......:.|.|:.:|   .|:.|...:..|..:|
  Fly   550 SNHQIPAGVTLE------PCDHQP-PAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDAN 607

Human   426 ----MYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEE 486
                ..||   .|...|...|:|..|:..|...:.|..|:.:||.   :|:.
  Fly   608 LVTEFIRQ---HTSPLGSGRYICHLCSTEFRQFKGLQNHMHSHTN---WIRA------------- 653

Human   487 EAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQHEKTHWLTRPFP-CNICGKMFTQRGTMTR 550
                        ..:.:| :|.:|.|::|.|..||.|.|||......| |.||.:.|..:..:.|
  Fly   654 ------------NCKKQP-QCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYR 705

Human   551 HMRSHLGLKPFACD--ECGMRFTRQYRLTEHM-RVHSG--EKPYECQLCGGKFTQQRNLISHLRM 610
            |.::| ..:.:.|.  .|...|:....|..|: |.|..  :..::|..||..:..    :..|::
  Fly   706 HRQTH-QQRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSLYDN----VDSLQL 765

Human   611 H 611
            |
  Fly   766 H 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIC2	NP_055909.2	BTB	40..140	CDD:279045	6/35 (17%)
		BTB	47..141	CDD:197585	7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..167		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..421		47/300 (16%)
		Binding to CtBP	246..250		2/3 (67%)
		TMEM119	<300..395	CDD:292352	23/140 (16%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		zf-C2H2	505..527	CDD:278523	9/21 (43%)
		C2H2 Zn finger	507..527	CDD:275368	9/19 (47%)
		zf-C2H2	533..555	CDD:278523	7/22 (32%)
		C2H2 Zn finger	535..555	CDD:275368	6/19 (32%)
		zf-H2C2_2	548..572	CDD:290200	6/25 (24%)
		COG5048	559..>613	CDD:227381	12/58 (21%)
		C2H2 Zn finger	563..583	CDD:275368	6/22 (27%)
		zf-H2C2_2	576..600	CDD:290200	7/26 (27%)
		C2H2 Zn finger	591..611	CDD:275368	4/19 (21%)
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	17/114 (15%)
		C2H2 Zn finger	627..647	CDD:275368	5/19 (26%)
		C2H2 Zn finger	661..681	CDD:275368	9/19 (47%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	6/22 (27%)
		C2H2 Zn finger	750..767	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100