DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NFASC and Cont

DIOPT Version :9

Sequence 1:	XP_024310051.1	Gene:	NFASC / 23114	HGNCID:	29866	Length:	1513	Species:	Homo sapiens
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	1104	Identity:	263/1104 - (23%)
Similarity:	446/1104 - (40%)	Gaps:	199/1104 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   168 LSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 232
            |.:.....||..|..   :.||...|....|:.::   :::.:.|.|.|.|.||:.|.|     .
  Fly   350 LDINDMERIPRGPYF---VKQPNDTTFDVNKNRLI---NDVTLSCLANGYPTPSYTWYR-----E 403

Human   233 IAKDPRVSMRR-----------RSGTLVIDFRSGGRPEEY--EGEYQCFARNKFGTALS------ 278
            :..|.|:..::           ..|.|:|     ..|::.  :|.|.|.|.||||...|
  Fly   404 VYVDDRLEYQKIDPLAQDRYTISGGNLII-----YEPKQALDQGAYHCVAENKFGRIRSESAHLN 463

Human   279 -------NRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQD 335
                   |..|...:....|.|              ::.|:||...|....:|....... :.:|
  Fly   464 FGFIMEFNLKRSAETSEMNWGK--------------SIFCDPPQHYPDVRYYWARDYFPNFVEED 514

Human   336 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN-HPDM 399
            :||....:|.||||.:...| :.:|||..:...:.|.:....|.|:|..|..|......| .|.:
  Fly   515 QRVFVSRDGALYFSFIETVD-RANYSCTVQTLVSDTGRNGPFFPLRVTPNSNYQALIFANTFPKV 578

Human   400 YSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NF 463
            :....||                    |.::.|||:|.|.|.|...|.::|  ||..:..:. |:
  Fly   579 FPEAPVA--------------------GDEIRLECMAFGYPIPSYNWTRQG--LPLQRNAYTINY 621

Human   464 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANG 528
            .:.|.|.|.:..|:|||.|..:|...::..:|.:.::..|.:....|::|.....|...:|.|..
  Fly   622 GRVLIIQNATTNDNGEYSCTITNPRKTLMKSIYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFA 686

Human   529 NPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR--------AVYQCNTSNEHGYLLA 585
            .|.....|..|.|.|.  |.|.||    |..|.:|..::.:        |:|||...|:.....:
  Fly   687 IPDANYTWYKNAERLD--PANINR----DRYIIQDNVLTIKFLEKDKDDAMYQCGAQNQLKTSFS 745

Human   586 NAFVSVLDVPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ--GSNLDGGNYHVY 647
            :|.:.||.:.|.... |....:..:....|.:.|....:|.|..:|.|:||  ||   ||:..:.
  Fly   746 SAQLRVLSMKPSFKKHPLESEVYAVYNGNTTIVCDPEAAPRPKFQWKKDGQVIGS---GGHRRIL 807

Human   648 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQ-VARRGTTVQLECRV 711
            .:|:|.|....::|:|||||:|:|..|..|:..|:.|....|....|..: |::....:.|.|..
  Fly   808 PSGTLTISPTSRDDEGIYTCIASNQAGTDESHARVIVLQEIRFIETPPQRIVSKEHDLIFLHCEA 872

Human   712 KHDPSLKLTVSWLKDDEPLYIGN----RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAY 772
            ..|..|.:...|..:.|.|...:    |:..:.:.||:...:.||.|.|.||..:.:::..:|..
  Fly   873 AFDELLDIAYVWKHNGEVLKNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTS 937

Human   773 LTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQ 837
            :::               :|.|..|..:::..:::....:.|:.|..|...|..|.:....:
  Fly   938 VSI---------------EGAPGAPGGVQVIQISKTKAIIEWVDGSHNGRAIRYYNILGRTN--- 984

Human   838 PGVWH-------------DHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTS 889
               |:             :..:|.....:.|:.|:|:..|:|.|.|:|::|...||.||..|.|.
  Fly   985 ---WNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWSAYEFSVTAVNDLGIGTPSAPSPIYSTY 1046

Human   890 GAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYV- 953
            ...|...|.:|.|.|.:..::.|||.|:.........:.|.|.|:.:...|       |.|..:
  Fly  1047 EDKPYIAPRNVGGGGGKIGDLTITWDPLLPQEQHSHGIHYKVFWKLKGAIE-------WASDEIK 1104

Human   954 ----VGQTPVYVP-------YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 1007
                :|...|.:|       ||::|||.|..|||||.|..:.:|.||.|:.||.:......|||.
  Fly  1105 KQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIAVIHSAEDMPQVAPQKPIALAYNSTC 1169

Human  1008 ISLQWNRV--YSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLR--GVVSRLFPYS 1068
            .::.|..:  ..:.::|:|..:|..||:.:        .|:.....:.....|  .::..|.|.:
  Fly  1170 FNVTWQPIDMSRENIRGKLIGHRLKYWKTT--------HQEEDSVYYLSRTTRNWALIVGLQPDT 1226

Human  1069 NYKLEMVVVNGRGDGPRSETKEFTT----PEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNGI 1127
            .|.::::..|..|:||.||..|..|    |:..||:...:.:   |..|:.:.|.:  |......
  Fly  1227 YYFVKVMAYNAAGEGPESERFEERTYRKAPQKPPSSVHVYGI---NPSTVRVVWRYVSPSQDEEP 1288

Human  1128 MIGYTLK-------YVAFNGT--KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSG 1182
            :.||.::       .:..|.|  .:|::: |::..|.|        |...|...:.|.:..|.|
  Fly  1289 VEGYKVRIWESDQNMITANNTIVPIGQKL-ESYINNLT--------PGKSYNMRVLAYSNGGDG 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NFASC	XP_024310051.1	Ig_hNeurofascin_like	208..284	CDD:143283	25/101 (25%)
		Ig	289..381	CDD:325142	21/92 (23%)
		Ig3_L1-CAM_like	430..500	CDD:319298	22/70 (31%)
		Ig	517..592	CDD:325142	21/82 (26%)
		Ig	615..681	CDD:319273	24/67 (36%)
		I-set	694..775	CDD:254352	19/85 (22%)
		FN3	794..884	CDD:238020	21/102 (21%)
		FN3	895..985	CDD:238020	29/101 (29%)
		FN3	994..1093	CDD:238020	23/102 (23%)
		FN3	1098..1189	CDD:238020	19/96 (20%)
		fn3	1287..1359	CDD:306538
		Bravo_FIGEY	1405..1489	CDD:316405
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845	28/114 (25%)
		I-set	362..462	CDD:254352	28/115 (24%)
		Ig	466..559	CDD:299845	23/107 (21%)
		IG_like	584..657	CDD:214653	25/94 (27%)
		IGc2	586..645	CDD:197706	21/60 (35%)
		Ig	667..751	CDD:299845	23/89 (26%)
		IG_like	676..751	CDD:214653	21/80 (26%)
		IG_like	765..844	CDD:214653	26/81 (32%)
		Ig	773..844	CDD:299845	26/73 (36%)
		I-set	851..940	CDD:254352	19/88 (22%)
		Ig	866..944	CDD:299845	18/92 (20%)
		FN3	944..1043	CDD:238020	22/104 (21%)
		FN3	1053..1146	CDD:238020	29/99 (29%)
		fn3	1156..1244	CDD:278470	20/95 (21%)
		fn3	1259..1346	CDD:278470	19/97 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810