DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPART and spartb

DIOPT Version :9

Sequence 1:	NP_001135766.1	Gene:	SPART / 23111	HGNCID:	18514	Length:	666	Species:	Homo sapiens
Sequence 2:	NP_001038916.1	Gene:	spartb / 751741	ZFINID:	ZDB-GENE-060825-146	Length:	269	Species:	Danio rerio

Alignment Length:	289	Identity:	141/289 - (48%)
Similarity:	174/289 - (60%)	Gaps:	24/289 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEQEPQNG-EPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISISSKES 64
            |||..|:. :.|.:::|::.|:|||..:|||||.||.|.||||...|:||..||||.||:.|:..
Zfish     1 MEQAKQDRFDHARLQVIKDGYEKAFECINKGLNEDEAGHKEEALKLYQQGRQHLLRAISVPSQGV 65

Human    65 EHTGPGWESARQMQQKMKETLQNVRTRLEILEKGLA-TSLQNDLQEVPKLYPEFPPKDMCEKLPE 128
            |..||.||||||||.||:|||.|:.|||.|||...| ..:.|......|||||. ||.|.::...
Zfish    66 ECVGPSWESARQMQHKMQETLSNITTRLAILETTPAPNEVSNGTAAAQKLYPEV-PKVMPQRPTP 129

Human   129 PQSFSSAPQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTVSYGTDSGE 193
            ||:         :||..:..|.|..:....   |:..|  |.|||||||||:||.|:||||||||
Zfish   130 PQT---------INGRVAGASGGQTSPTVQ---PNILC--EQPPAYTPQAADGHLTISYGTDSGE 180

Human   194 FSSVGEEFYRNHSQPPPL-ETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRFLDNS 257
            ...||:|||...|...|. .:||.|.:||..:|.|||||||.|.|.|||||||||||||:|....
Zfish   181 LPVVGDEFYSQTSNSTPAGSSLGEDGEELFFLPQGVQIFFVTPEGHVSAPSYPGYLRIVKFTSEH 245

Human   258 LDTVLNRPPGFLQVCDWLYPLVPDRSPVL 286
            .:.:.||||.||||      .:..:||.|
Zfish   246 SERIPNRPPAFLQV------RIYKKSPCL 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPART	NP_001135766.1	MIT_spastin	16..95	CDD:239142	47/78 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..156		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..398
		Senescence	427..611	CDD:311082
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..666
spartb	NP_001038916.1	MIT_spastin	17..96	CDD:239142	47/78 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335357
Domainoid	1	1.000	285	1.000	Domainoid score	I8011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	638	1.000	Inparanoid score	I4879
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50452
OrthoDB	1	1.010	-	-		D290487at33208
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		oto42429
orthoMCL	1	0.900	-	-		OOG6_107088
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7703
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.410