DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPART and spartin

DIOPT Version :9

Sequence 1:	NP_001135766.1	Gene:	SPART / 23111	HGNCID:	18514	Length:	666	Species:	Homo sapiens
Sequence 2:	NP_001246910.1	Gene:	spartin / 40582	FlyBaseID:	FBgn0037265	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	650	Identity:	162/650 - (24%)
Similarity:	259/650 - (39%)	Gaps:	172/650 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    16 IREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHL--LRGI------SISSKESEHTGPGWE 72
            ||.|||.|...|:..::.:|.....:|...|:..:..:  ..||      .|.:.::|     |.
  Fly    15 IRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAE-----WN 74

Human    73 SARQMQQKMKETLQNVRTRLEILEKGLATSLQNDLQEVPKLYPEFPPKDMCEKLPEPQSFSSAPQ 137
            .|..:.||:|.....:|.||::| :....|:.:...|.    .|....:|..|.|        |.
  Fly    75 DACALIQKLKSAETELRYRLKVL-RSQKQSIDDSAVEA----TEESRAEMDTKRP--------PL 126

Human   138 HAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTVSYGTDSGEFSSVGEEFY 202
            .||   |.||....|.|             :.||..|...||
  Fly   127 LAE---NPSTQYGIANA-------------SGAPKTYRELAA----------------------- 152

Human   203 RNHSQPPPLETLGL-------DADELI--LIPNGVQIFFVNPAGEVSAPSYPG------------ 246
                        ||       ||..|:  |....|:::.:..:|.|:..|...
  Fly   153 ------------GLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGK 205

Human   247 --YLRIVRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGV 309
              ||..:.|:..|:       |.......|||||||..:...:...||::|||...|..|...|:
  Fly   206 WKYLSGIYFIQCSM-------PNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGL 263

Human   310 VLSSE----LPEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVK 370
            :|:.|    ..||:   .|||.:...|| |:|                         ..:|| |.
  Fly   264 MLTKEGQTSRTEDE---LEDLQQFFLDL-LEA-------------------------VLAGT-VV 298

Human   371 QLDQGNKDVRHKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVS 435
            ||....      .:|...|.||.|                        .||:|:.:|:|.|.:::
  Fly   299 QLKSPT------SQRAGLASDTVS------------------------GSEQVSRHIVSAADFIA 333

Human   436 WGLVKGAEITGKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCT 500
            ..||:|||.||..:.:....:..::.|.....:|..:|...:.:|::.|..||.::.::...|.|
  Fly   334 SNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGT 398

Human   501 VANCVGKELAPHVKKHGSKLVPESLKKD-KDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIV 564
            .:..||:.||||:::.||||:.:....| .:..|.::|||.:||.:|:|.|||:.|||.:||.:.
  Fly   399 ASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILG 463

Human   565 NNVSAETVQTVRYKYGYNAGEATHHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQ 629
            :::|..:|:.:.:|||...|.......|:..||.|.:.|:|.|..|.:.||...:||..::.||:
  Fly   464 SSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPART	NP_001135766.1	MIT_spastin	16..95	CDD:239142	22/86 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..156		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..398		10/53 (19%)
		Senescence	427..611	CDD:311082	59/184 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..666
spartin	NP_001246910.1	MIT_spastin	15..97	CDD:239142	22/86 (26%)
spartin	NP_001246910.1	Senescence	325..511	CDD:284359	60/185 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152763
Domainoid	1	1.000	110	1.000	Domainoid score	I6310
eggNOG	1	0.900	-	-		E1_KOG2709
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4512
Isobase	1	0.950	-	0	Normalized mean entropy	S7342
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290487at33208
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		oto89486
orthoMCL	1	0.900	-	-		OOG6_107088
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3532
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740