Protein Alignment SPART and spart

DIOPT Version :10

• Sequence 1: NP_055902.1
• Gene: SPART / 23111
• HGNCID: 18514
• Length: 666
• Species: Homo sapiens
• Sequence 2: XP_031751587.1
• Gene: spart / 100170472
• XenbaseID: XB-GENE-990805
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 373/650 - (57%)
• Similarity: 458/650 - (70%)
• Gaps: 70/650 - (10%)

Human     1 MEQE--PQNGEPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISISSKE 63
            ||:.  |:|.|...::.|.:.|:|||.::||||:|||.|.||||:||||||..||:||::||.:.
 Frog     3 MEKNAPPENLENTLLRSIEDEYRKAFKYINKGLSTDETGYKEEARNYYKQGQEHLIRGLNISLQR 67

Human    64 SEHTGPGWESARQMQQKMKETLQNVRTRLEILEKGLATSL------QNDLQEVPKLYPEFPP--K 120
            .|.|||.|::|||||.||:||||||.|||.||::.| |||      :|...::|.|||..||  |
 Frog    68 PEFTGPAWDNARQMQAKMEETLQNVNTRLNILQQSL-TSLPSNSAAENASSQMPALYPALPPKEK 131

Human   121 DMCEKLPEPQSFSSAPQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTV 185
            :..|:.|.|.|.....:...|||.:|.||:..| .|..   |....|  .||||||||.||||||
 Frog   132 EKPERPPPPISLVCPSEPCPVNGFSSVPSSETV-QPID---PIMGAP--TPPAYTPQATEGHYTV 190

Human   186 SYGTDSGEFSSVGEEFYRNHSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRI 250
            ||||:|||.|:||.|||...:||||:::||:||:||||||.|||||||...|.|:||||||||||
 Frog   191 SYGTESGELSTVGVEFYSMAAQPPPVQSLGVDAEELILIPQGVQIFFVTADGLVTAPSYPGYLRI 255

Human   251 VRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGVVLSSEL 315
            ::|:|.:.:...||||.|||||||||||:..:||||:...|.|||||.|.|..|.:|||||||||
 Frog   256 IKFMDTNSEVAQNRPPAFLQVCDWLYPLMCTQSPVLRTNTGVYMFPDVMSQLPGSYVGVVLSSEL 320

Human   316 PEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVKQLDQGNKDVR 380
            |..|:||||||||||||||:|                   ||
 Frog   321 PIADQELFEDLLRQMSDLRIQ-------------------PS----------------------- 343

Human   381 HKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVSWGLVKGAEIT 445
                      :.:||.:::|..|....:|||:.|||||||||||..|||||||:||||.||||:|
 Frog   344 ----------EAASEVIDVSQTVHIITIPEEEEKELPEWSEKVAQGILSGASWISWGLAKGAELT 398

Human   446 GKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCTVANCVGKELA 510
            .|||.||||||||.||||:||:||||.|.|||::||||||||.|||||||||||::|:|||:|||
 Frog   399 EKAIHKGASKLREHIQPEDKPLEVSPTVAKGLHVAKQATGGAVKVSQFLVDGVCSIASCVGRELA 463

Human   511 PHVKKHGSKLVPESLKKDKDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTV 575
            ||||||||||:||||||||||||||||||.||||.||||:|||||||.|.|.|..:|::|||.|:
 Frog   464 PHVKKHGSKLLPESLKKDKDGKSPLDGAMAVAASGVQGFATVWQGLEFAGKNIAKSVASETVHTI 528

Human   576 RYKYGYNAGEATHHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQIVDNSQRENQE 640
            ::|||.:||..|.:||.||:|||.||:||:||||||:|||||.:|.|.:|::|:| :..|.|.:|
 Frog   529 KHKYGKDAGHVTDNAVHSAMNVGATAFNIDNIGIKALVKKTAKETSHAILDEYKI-NKKQDEKEE 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPART	NP_055902.1	MIT_spastin	16..95	CDD:239142	50/78 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..156		11/31 (35%)
		Ubiquitin-binding region (UBR) domain. /evidence=ECO:0000269|PubMed:37443287	190..380		100/189 (53%)
		LC3-interacting region (LIR), mediates interaction with MAP1LC3A AND MAP1LC3C. /evidence=ECO:0000269|PubMed:37443287	193..200		4/6 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..398		4/53 (8%)
		Senescence	427..617	CDD:462037	144/189 (76%)
		Required for localization to lipid droplets. /evidence=ECO:0000269|PubMed:37443287	431..503		56/71 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..666		1/4 (25%)
spart	XP_031751587.1	MIT_spastin	20..99	CDD:239142	50/78 (64%)
		Senescence	378..571	CDD:462037	145/192 (76%)