Protein Alignment SPART and spart

DIOPT Version :9

• Sequence 1: NP_001135766.1
• Gene: SPART / 23111
• HGNCID: 18514
• Length: 666
• Species: Homo sapiens
• Sequence 2: XP_031751587.1
• Gene: spart / 100170472
• XenbaseID: XB-GENE-990805
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 373/650 - (57%)
• Similarity: 458/650 - (70%)
• Gaps: 70/650 - (10%)

Human     1 MEQE--PQNGEPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISISSKE 63
            ||:.  |:|.|...::.|.:.|:|||.::||||:|||.|.||||:||||||..||:||::||.:.
 Frog     3 MEKNAPPENLENTLLRSIEDEYRKAFKYINKGLSTDETGYKEEARNYYKQGQEHLIRGLNISLQR 67

Human    64 SEHTGPGWESARQMQQKMKETLQNVRTRLEILEKGLATSL------QNDLQEVPKLYPEFPP--K 120
            .|.|||.|::|||||.||:||||||.|||.||::.| |||      :|...::|.|||..||  |
 Frog    68 PEFTGPAWDNARQMQAKMEETLQNVNTRLNILQQSL-TSLPSNSAAENASSQMPALYPALPPKEK 131

Human   121 DMCEKLPEPQSFSSAPQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTV 185
            :..|:.|.|.|.....:...|||.:|.||:..| .|..   |....|  .||||||||.||||||
 Frog   132 EKPERPPPPISLVCPSEPCPVNGFSSVPSSETV-QPID---PIMGAP--TPPAYTPQATEGHYTV 190

Human   186 SYGTDSGEFSSVGEEFYRNHSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRI 250
            ||||:|||.|:||.|||...:||||:::||:||:||||||.|||||||...|.|:||||||||||
 Frog   191 SYGTESGELSTVGVEFYSMAAQPPPVQSLGVDAEELILIPQGVQIFFVTADGLVTAPSYPGYLRI 255

Human   251 VRFLDNSLDTVLNRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGVVLSSEL 315
            ::|:|.:.:...||||.|||||||||||:..:||||:...|.|||||.|.|..|.:|||||||||
 Frog   256 IKFMDTNSEVAQNRPPAFLQVCDWLYPLMCTQSPVLRTNTGVYMFPDVMSQLPGSYVGVVLSSEL 320

Human   316 PEDDRELFEDLLRQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVKQLDQGNKDVR 380
            |..|:||||||||||||||:|                   ||
 Frog   321 PIADQELFEDLLRQMSDLRIQ-------------------PS----------------------- 343

Human   381 HKGKRGKRAKDTSSEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVSWGLVKGAEIT 445
                      :.:||.:::|..|....:|||:.|||||||||||..|||||||:||||.||||:|
 Frog   344 ----------EAASEVIDVSQTVHIITIPEEEEKELPEWSEKVAQGILSGASWISWGLAKGAELT 398

Human   446 GKAIQKGASKLRERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCTVANCVGKELA 510
            .|||.||||||||.||||:||:||||.|.|||::||||||||.|||||||||||::|:|||:|||
 Frog   399 EKAIHKGASKLREHIQPEDKPLEVSPTVAKGLHVAKQATGGAVKVSQFLVDGVCSIASCVGRELA 463

Human   511 PHVKKHGSKLVPESLKKDKDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTV 575
            ||||||||||:||||||||||||||||||.||||.||||:|||||||.|.|.|..:|::|||.|:
 Frog   464 PHVKKHGSKLLPESLKKDKDGKSPLDGAMAVAASGVQGFATVWQGLEFAGKNIAKSVASETVHTI 528

Human   576 RYKYGYNAGEATHHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQIVDNSQRENQE 640
            ::|||.:||..|.:||.||:|||.||:||:||||||:|||||.:|.|.:|::|:| :..|.|.:|
 Frog   529 KHKYGKDAGHVTDNAVHSAMNVGATAFNIDNIGIKALVKKTAKETSHAILDEYKI-NKKQDEKEE 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPART	NP_001135766.1	MIT_spastin	16..95	CDD:239142	50/78 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..156		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..398		4/53 (8%)
		Senescence	427..611	CDD:311082	139/183 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..666		1/4 (25%)
spart	XP_031751587.1	MIT_spastin	20..99	CDD:239142	50/78 (64%)
		Senescence	380..564	CDD:399715	139/183 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I6291
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32243
Inparanoid	1	1.050	702	1.000	Inparanoid score	I5328
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50452
OrthoDB	1	1.010	-	-		D145562at32523
OrthoFinder	1	1.000	-	-		FOG0006009
OrthoInspector	1	1.000	-	-		oto154237
Panther	1	1.100	-	-	LDO	PTHR21068
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3532
SonicParanoid	1	1.000	-	-		X7703
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110