Protein Alignment SPART and sparta

DIOPT Version :10

• Sequence 1: NP_055902.1
• Gene: SPART / 23111
• HGNCID: 18514
• Length: 666
• Species: Homo sapiens
• Sequence 2: NP_001107130.1
• Gene: sparta / 100005765
• ZFINID: ZDB-GENE-080204-37
• Length: 567
• Species: Danio rerio
• Alignment Length: 663
• Identity: 282/663 - (42%)
• Similarity: 376/663 - (56%)
• Gaps: 101/663 - (15%)

Human     6 QNGEPAEIKIIREAYKKAFLFVNKGLNTDELGQKEEAKNYYKQGIGHLLRGISISSKESEHTGPG 70
            |..|||||::|||.|.||...:|.||..||.|.|::|...|:.|..|||.|:.:.::....||..
Zfish     2 QTPEPAEIRVIRENYDKALQCLNTGLQLDEAGNKDQALVLYRLGRRHLLSGLQVDTRGGRCTGRC 66

Human    71 WESARQMQQKMKETLQNVRTRLEILEKGLATSLQNDLQEVPKLYPEFPPKDMCEKLPEPQSFSSA 135
            |:||||.|.||.|||:.:..||..||....|.        .:|||..|   :.:.....::|:|
Zfish    67 WDSARQTQLKMGETLRTITARLGALESASNTG--------QRLYPTLP---VFQDKNSQRAFNS- 119

Human   136 PQHAEVNGNTSTPSAGAVAAPASLSLPSQSCPAEAPPAYTPQAAEGHYTVSYGTDSGEFSSVGEE 200
                  .|.:....:..|:.|...::|:     |.|||||||..:||.::|:|.:.....:..:.
Zfish   120 ------RGASGRAPSRPVSPPVGFAVPN-----ELPPAYTPQPTDGHLSLSHGANRAFPDAPHQG 173

Human   201 FYRNHSQPPPLETLGLDADELILIPNGVQIFFVNPAGEVSAPSYPGYLRIVRF---LDNSLDTVL 262
            ..|....|..|...|:   |::.:|:|||:|||:..|.|:||||||||||:.:   .|.|.:|
Zfish   174 SRRQAVAPVNLREAGM---EIMFLPSGVQMFFVSAEGRVTAPSYPGYLRIIIYSQDSDGSANT-- 233

Human   263 NRPPGFLQVCDWLYPLVPDRSPVLKCTAGAYMFPDTMLQAAGCFVGVVLSSELPEDDRELFEDLL 327
            ...|.:||||||:|||.|| .|||....|.:.||||.....|.:|||||||:||..:|:||::.|
Zfish   234 GYAPAYLQVCDWIYPLYPD-FPVLLSNNGVFTFPDTTAAVPGSYVGVVLSSDLPAGERDLFQEQL 297

Human   328 RQMSDLRLQANWNRAEEENEFQIPGRTRPSSDQLKEASGTDVKQLDQGNKDVRHKGKRGKRAKDT 392
            ..::.||:|.:                                  ::|.         |....||
Zfish   298 SVLAQLRVQVD----------------------------------EEGG---------GATGADT 319

Human   393 S-SEEVNLSHIVPCEPVPEEKPKELPEWSEKVAHNILSGASWVSWGLVKGAEITGKAIQKGASKL 456
            : ||::.||.   ....|||  |..|.||||::.:||:|:||:..|||:|||.||||||:|.:||
Zfish   320 NLSEKIPLSE---ASQTPEE--KTAPVWSEKMSQSILAGSSWLGRGLVRGAEATGKAIQRGGTKL 379

Human   457 RERIQPEEKPVEVSPAVTKGLYIAKQATGGAAKVSQFLVDGVCTVANCVGKELAPHVKKHGSKLV 521
            |:.|.|||.|.||||.|||||..||||||||.||||||||||..||..|||||||||||||.||:
Zfish   380 RDNITPEETPAEVSPKVTKGLNAAKQATGGAVKVSQFLVDGVAAVAGKVGKELAPHVKKHGCKLI 444

Human   522 PESLKKDKDGKSPLDGAMVVAASSVQGFSTVWQGLECAAKCIVNNVSAETVQTVRYKYGYNAGEA 586
            ||||||.|||.|.:|||.:||.||:||.||:|..||.|.|.|..::|:|||.|||:|||..||:|
Zfish   445 PESLKKGKDGSSKMDGAKLVAGSSIQGLSTLWSSLETAGKTIGKSLSSETVTTVRHKYGDEAGQA 509

Human   587 THHAVDSAVNVGVTAYNINNIGIKAMVKKTATQTGHTLLEDYQIVDNSQRENQEGAANVNVRGEK 651
            ...||.|.|||||||:|::|:.:|.::|.|..||...:::|                  ..:|||
Zfish   510 ADTAVQSTVNVGVTAFNMDNVCLKGVLKATGKQTTKEIVKD------------------TPKGEK 556

Human   652 DEQTKEVKEAKKK 664
            .|.  :.|..||:
Zfish   557 TED--KDKSPKKR 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPART	NP_055902.1	MIT_spastin	16..95	CDD:239142	35/78 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..156		4/31 (13%)
		Ubiquitin-binding region (UBR) domain. /evidence=ECO:0000269|PubMed:37443287	190..380		65/192 (34%)
		LC3-interacting region (LIR), mediates interaction with MAP1LC3A AND MAP1LC3C. /evidence=ECO:0000269|PubMed:37443287	193..200		0/6 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..398		6/54 (11%)
		Senescence	427..617	CDD:462037	124/189 (66%)
		Required for localization to lipid droplets. /evidence=ECO:0000269|PubMed:37443287	431..503		51/71 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..666		7/29 (24%)
sparta	NP_001107130.1	MIT	12..91	CDD:469712	35/78 (45%)
		Senescence	348..541	CDD:462037	125/192 (65%)