DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MCF2L2 and zormin

DIOPT Version :9

Sequence 1:NP_055893.4 Gene:MCF2L2 / 23101 HGNCID:30319 Length:1114 Species:Homo sapiens
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:1124 Identity:209/1124 - (18%)
Similarity:388/1124 - (34%) Gaps:359/1124 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   105 DRRRD---KWSSVKASLTR-IAVAFPGN--LQLIFILRPSRFIQRTFTDIG-IKYYRNEFKTKV- 161
            |||..   .|.:.|..:.: :|:|..|.  :.|...|:.:|....|...:| .::..||..||. 
  Fly   312 DRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAALQQARMELNTMYSLGECEHTANEMLTKYR 376

Human   162 -----PIIMVNSVSDLHGYIDKSQ----LTRE---------LGGTLEY-----RHGQWVNHRTAI 203
                 .:::.:....:....:|.|    .|.|         |.|..|:     :...|: |::  
  Fly   377 EWKQQALLLRDRALKITRAKEKVQSAGHFTEEDACARAYAVLSGCTEHLDLVDQREHWL-HQS-- 438

Human   204 ENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDK---LQDELKL----LGKQG 261
            ..|....:.|..:|:.....|.:.:||..  |.|...|.....||.   .::.|:|    |.:.|
  Fly   439 REFFAKAEHTVSVLEKLELELTSVKLPPH--SPESYAMFSKVDRDVRNFTEEPLRLGYGILDEVG 501

Human   262 TTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQ---------LDETEKAFSHFWSEHHLKLN 317
            .|      :|.|:  ..|..|::|||    .::.:|         ..:.::|.|.|.: ||.:|.
  Fly   502 RT------QPETQ--GVKRVLDELEN----RKVYIQGICANSSEDQQKVQRALSEFLN-HHNELL 553

Human   318 QCLQL--QHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLE-KAQL 379
            ..|:.  ||              .|::..:   :|.::...:|.|.:|.:|    .:.|| |.:|
  Fly   554 AWLRASGQH--------------QLQQSVD---MGGNLQQAKQFLLQHHEL----MQDLEIKGEL 597

Human   380 LALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGI 444
            :.|    |::|.....:::.|                ::::|:..|:...|:      .|.|...
  Fly   598 INL----LLESIKVHLESLSP----------------QERYDVDSKAESLHK------HWIELKD 636

Human   445 YLL-----ASQAVDKCQSREGVDIALNDI-----------------ATFLGTVKEYPLLSPK--E 485
            .:|     .|..:|..:....:...|:::                 ||:.|....:..|..:  .
  Fly   637 LVLKRVDYVSLLIDFFELANELSSQLDNLQRQLQQTPDEHKLQFLQATWTGIASTFGELKSRGQR 701

Human   486 FYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSS 550
            |.|...:...|:.|:.||.|.:.|:|    |.||||.:                 ..|...|.:|
  Fly   702 FINLKIVDPYLETKSSAQAVQETLND----FSKRQVDV-----------------TSSLENWTTS 745

Human   551 KTSQPSTSVPLARPLRTSEEPYTE-TELNSR------GKEDDETKFEVKSEEIFES---HHERGN 605
            ...:......|.:.:..:||...: |:::::      .:..|..:..:.:.|...:   ..||..
  Fly   746 IAEKREVEYLLEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQ 810

Human   606 PELEQ--QARLG-------DLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDV 661
            .|::|  |..||       .|:...::|.:|        :.:|:.:||                 
  Fly   811 DEIQQRIQTTLGIQTKDQPSLAKIEQVINNL--------RMLKAKLDG----------------- 850

Human   662 LQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRA---R 723
                           .::..||.::.:.:..||       .::.:.::..||...:..|.:   |
  Fly   851 ---------------IKYDYRTLVESVIQFLEN-------IVQLRREIDDYFARQQKEPASGADR 893

Human   724 AIWQ------ECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGL----LDFESPEDM 778
            :|.:      :|.|.....:.|.:|  .:...:.|:.|..|.|....:||.|    |.|||    
  Fly   894 SIAEHEKFRDQCMDKFRSLITQSEL--LIDRVRVLEPPGAREIDTDRILKLLENLRLHFES---- 952

Human   779 EIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLL 843
                   ..||:                  ::.:|.|.|..:...||..:....|.:.:      
  Fly   953 -------NSSAR------------------MSTLERLEKIEQFRSDLEDIDRSLDSVSQ------ 986

Human   844 HGPFSVWTIHK-DRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQ-----GLSPHYSFKKT 902
                   .:|: :...:..|...|.:......|||.|.....|.....:     |.:.|     |
  Fly   987 -------QLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMPRQLKSTRHQRRWGQTAH-----T 1039

Human   903 MKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQ 967
            ::|:...|.:....:.::..|.:... |:|:.....| :.:.|.|  .|..::|:....:|....
  Fly  1040 IELLEKRIEKFTESTSQQLFITNPES-ERYVKDELRK-LNEKWQS--FKDQVKQKRKSLNQATDF 1100

Human   968 FEM----------------STSK-----GSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSRE 1011
            ||:                |.|.     .....:|..:.::|...||:|....            
  Fly  1101 FEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIENYVTSREAALR------------ 1153

Human  1012 FSSMDTFEDCEGAEDMEKESSALS-LAGLFQSDDSHETCSSKSAFL----------ERGESSQGE 1065
             |.:|:...|  |.||.|.||..: :..:|||            |:          ||.:..|.:
  Fly  1154 -SKLDSASQC--AHDMNKVSSLYNDVMNIFQS------------FIKLKMDINVVQERLKQEQRQ 1203

Human  1066 KEERDEEETATRSTEEERA 1084
            ||:|  |..|....|.|:|
  Fly  1204 KEQR--ERDARDQAEREKA 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MCF2L2NP_055893.4 SEC14 52..190 CDD:214706 23/110 (21%)
SPEC 321..523 CDD:238103 43/228 (19%)
Spectrin 323..428 18/105 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..614 14/95 (15%)
RhoGEF 623..820 CDD:214619 34/209 (16%)
PH-like 827..956 CDD:418428 21/134 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1114 34/155 (22%)
zorminNP_001261317.1 SPEC 126..332 CDD:238103 5/19 (26%)
SPEC <504..641 CDD:295325 37/190 (19%)
COG1340 960..1298 CDD:224259 61/312 (20%)
RILP-like <1190..1315 CDD:304877 11/33 (33%)
MAP7 1233..1365 CDD:283355
I-set 1390..1479 CDD:254352
IGc2 1403..1469 CDD:197706
I-set 1491..1580 CDD:254352
IGc2 1504..1570 CDD:197706
I-set 1589..1675 CDD:254352
Ig 1605..1675 CDD:299845
I-set 1702..1786 CDD:254352
Ig 1713..1786 CDD:299845
I-set 1811..1902 CDD:254352
Ig 1828..1892 CDD:143165
I-set 1927..2015 CDD:254352
IGc2 1940..2005 CDD:197706
I-set 2142..2231 CDD:254352
Ig 2158..2231 CDD:299845
I-set 2238..2325 CDD:254352
Ig 2254..2324 CDD:299845
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.