DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZBTB43 and CG6654

DIOPT Version :9

Sequence 1:NP_001129248.1 Gene:ZBTB43 / 23099 HGNCID:17908 Length:467 Species:Homo sapiens
Sequence 2:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster


Alignment Length:488 Identity:98/488 - (20%)
Similarity:151/488 - (30%) Gaps:174/488 - (35%)


- Green bases have known domain annotations that are detailed below.


Human     8 FRVEFPD-----FSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNS 67
            |..|.||     .:|.|||      .||.|.|...||    |.....:....     |..|.:..
  Fly   153 FDYELPDEPVEKTTSLILQ------VQGNLKDEKEVV----FTQTNVIYEGD-----DHELEQQI 202

Human    68 RRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQ 132
            |.      .|..:||.:  .:....:.:.||::.:..:||.                    :|.|
  Fly   203 RE------CNLAIFEGV--DNEAEIITVTAPQVTTRKSAAK--------------------LLTQ 239

Human   133 KLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEE--ESTKDELSSQLTEHEYL 195
            :.|  ..||:|..|.                     :|.|:.|.|:  :|.|.....:....:.:
  Fly   240 QEN--DKHQTPVGSK---------------------EEARELEKEQVPQSAKRTSRRRGVVKQDV 281

Human   196 P------SNSSTEHDRLSTE---MASQDG-------EEGASDSAEFHY-----TRPMYSKPSIMA 239
            |      :..|.:..||.|:   .|.:.|       ..||:.:.|..|     ......:.|:|.
  Fly   282 PATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMI 346

Human   240 HKRW---------------IHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEE 289
            |:|.               :.|.|:.|.             |||.:..      .|.....|:..
  Fly   347 HRRQKGCINRNYKCNECEKVFVSPDHLA-------------EHQASHG------AHNCPECGIRC 392

Human   290 DFHIGEKKVEAEFDEQADESNYDEQVDFYGSSMEEFSGERSDGNLIGHRQEAALAAGYSENIEMV 354
            |                              |.|..|.....|:....|.:..:..      ::.
  Fly   393 D------------------------------SKEALSKHMVQGHKRNLRNQCNICQ------KVF 421

Human   355 TGIKEEASHLGFSATDKLYPCQ-CGKSFTHKSQRDRHMSMHLGLRPYGCGVCGKKFKMKHHLVGH 418
            |.:.....|:.....:|.:.|. ||||||..:...:|...|...:.:.|.:|...|..|..|..|
  Fly   422 TMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSH 486

Human   419 MKIHTGIKPYECNICAKRFMWRDSFHRHVTSCT 451
            .:.|||.||:||.:|..||         .|||:
  Fly   487 ARTHTGDKPFECEVCLARF---------TTSCS 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZBTB43NP_001129248.1 BTB_POZ_ZBTB43 8..128 CDD:349536 25/124 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 134..153 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..225 15/80 (19%)
C2H2 Zn finger 376..394 CDD:275368 7/18 (39%)
C2H2 Zn finger 402..422 CDD:275368 6/19 (32%)
zf-H2C2_2 414..437 CDD:404364 10/22 (45%)
C2H2 Zn finger 430..447 CDD:275368 4/16 (25%)
CG6654NP_650429.1 zf-AD 6..79 CDD:285071
C2H2 Zn finger 331..354 CDD:275368 4/22 (18%)
COG5048 <357..570 CDD:227381 45/218 (21%)
C2H2 Zn finger 360..380 CDD:275368 6/32 (19%)
C2H2 Zn finger 385..406 CDD:275370 5/50 (10%)
C2H2 Zn finger 414..434 CDD:275368 2/25 (8%)
zf-H2C2_2 427..451 CDD:290200 8/23 (35%)
C2H2 Zn finger 442..490 CDD:275368 15/47 (32%)
C2H2 Zn finger 470..487 CDD:275368 5/16 (31%)
zf-H2C2_2 482..507 CDD:290200 12/33 (36%)
C2H2 Zn finger 498..518 CDD:275368 7/22 (32%)
zf-H2C2_2 510..534 CDD:290200 0/1 (0%)
C2H2 Zn finger 526..546 CDD:275368
zf-H2C2_2 539..563 CDD:290200
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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