Protein Alignment CDK19 and SSN3

DIOPT Version :10

• Sequence 1: NP_055891.1
• Gene: CDK19 / 23097
• HGNCID: 19338
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_015283.1
• Gene: SSN3 / 856065
• SGDID: S000005963
• Length: 555
• Species: Saccharomyces cerevisiae
• Alignment Length: 539
• Identity: 186/539 - (34%)
• Similarity: 252/539 - (46%)
• Gaps: 158/539 - (29%)

Human    12 ERERVEDLFEYEGC-KVGRGTYGHVYKARRK-------------DG------------------- 43
            :|.||..|.:||.. .:..||||.||||:|:             :|
Yeast    65 DRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSM 129

Human    44 --------------KDE---------------------KE----------YALK----------Q 53
                          |||                     |:          ||:|          |
Yeast   130 DMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQ 194

Human    54 IEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRK-VWLLFDYAEHDLWHIIKFHRASKAN 117
            :..||||.|||||:||.|||.:.::..|.::||   :|| |.::::||||||..||.||    ::
Yeast   195 LHYTGISQSACREMALCRELHNKHLTTLVEIFL---ERKCVHMVYEYAEHDLLQIIHFH----SH 252

Human   118 KKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNS 182
            .:...:|..||:|:::|:|||:.|||.|||||||||||||:|..:    |.|||.|:|.||.|::
Yeast   253 PEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTID----GCVKIGDLGLARKFHN 313

Human   183 PLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSN 245
            .|:.|...|.||||.|||||||||||||||.|:|:|::|||||||:..:|||...:.  |.|.:.
Yeast   314 MLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTV 378

Human   246 PFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQK-----DFRRTTYANSSLIKYMEKHKVKPD 305
            ||..:||.||..|:|.|..|.|..:.|.|||..:.|     |...|.|.::.   ..:||.:.
Yeast   379 PFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAG---GRDKHALS-- 438

Human   306 SKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLD-VFAGCQIPYPKREF-LNEDDPEEKG 368
                 ||..||..||.|||.:..||:..||.|..:|..: ||.|....||.|.. .|::|....|
Yeast   439 -----LLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLG 498

Human   369 DKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNG-TAGGAGAGVGGTG----------AG 422
            .:.                            :|:||.:| |||.|...:||.|          |.
Yeast   499 SRT----------------------------KNNTQASGITAGAAANALGGLGVNRRILAAAAAA 535

Human   423 LQHSQDSSLNQVPPNKKPR 441
            ......::.:..|..||.|
Yeast   536 AAAVSGNNASDEPSRKKNR 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK19	NP_055891.1	STKc_CDC2L6	18..335	CDD:270850	154/412 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	359..502		19/94 (20%)
SSN3	NP_015283.1	STKc_CDK8_like	74..463	CDD:270834	153/409 (37%)