Protein Alignment CDK19 and Cdk8

DIOPT Version :9

• Sequence 1: XP_024302144.1
• Gene: CDK19 / 23097
• HGNCID: 19338
• Length: 599
• Species: Homo sapiens
• Sequence 2: NP_536735.2
• Gene: Cdk8 / 39157
• FlyBaseID: FBgn0015618
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 445
• Identity: 302/445 - (67%)
• Similarity: 334/445 - (75%)
• Gaps: 37/445 - (8%)

Human   142 DEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIK 206
            |.||||||||:|||:||||||||||||||||.|||.|.:|||||:||||:||.||||||||||||
  Fly    45 DGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIK 109

Human   207 FHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 271
            ||||:||.||.:.:||.|||||||||||||||||:|||||||||||||||||:|.||||||||||
  Fly   110 FHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADM 174

Human   272 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQE 336
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   175 GFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQE 239

Human   337 DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKP 401
            |||||||:|||||||||:|||||.|||||||:||||:.||.|||:|:||:..||.||||:||:||
  Fly   240 DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKP 304

Human   402 DSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGD 466
            |||.|.||||||.|||.||||||||:||.||||:|.||.||||||.|||||||||.:||.|:|.|
  Fly   305 DSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSD 369

Human   467 KNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQV 531
            ..:||||.|.||            |....||...|.                  |..|...:|..
  Fly   370 NKRQQQQQQQQQ------------QQQQQQQQQQQQ------------------QQQQQQQMNAE 404

Human   532 PPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQ 586
            |..|:.||  |||.:     ..|:.|...:...|...|...|.|.......:.|:
  Fly   405 PNAKRVRL--SGAGN-----QQDFHHQQQQQQQQQQQQQQQQQQMMFNQQQNFQR 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK19	XP_024302144.1	PKc_like	141..432	CDD:328722	247/289 (85%)
Cdk8	NP_536735.2	STKc_CDK8_like	19..335	CDD:270834	247/289 (85%)
		S_TKc	22..335	CDD:214567	247/289 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140668
Domainoid	1	1.000	571	1.000	Domainoid score	I226
eggNOG	1	0.900	-	-		E1_KOG0666
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287471at33208
OrthoFinder	1	1.000	-	-		FOG0002084
OrthoInspector	1	1.000	-	-		otm40270
orthoMCL	1	0.900	-	-		OOG6_102974
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1399
SonicParanoid	1	1.000	-	-		X1379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790