Protein Alignment CDK19 and srb10

DIOPT Version :10

• Sequence 1: NP_055891.1
• Gene: CDK19 / 23097
• HGNCID: 19338
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_593389.2
• Gene: srb10 / 2541900
• PomBaseID: SPAC23H4.17C
• Length: 369
• Species: Schizosaccharomyces pombe
• Alignment Length: 354
• Identity: 147/354 - (41%)
• Similarity: 212/354 - (59%)
• Gaps: 31/354 - (8%)

Human    27 VGRGTYGHVYKARRKDGKDEKEYALKQIEG-----------TGISMSACREIALLRELKHPNVIA 80
            :..||||.||||...:..|::.:|:|:.:.           ||:|.||.||:.|.||::|.|:::
pombe    11 ISSGTYGKVYKAVSSNSNDKRLFAIKKFKAESKQVSSNAQQTGVSQSAIREMMLCREIQHENIVS 75

Human    81 LQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHAN 145
            |.:|.|  .|..:.::|:||||||..||.||..|:..    |:|.|::||:|:||::|:.|||.|
pombe    76 LVQVLL--KDGTISMVFEYAEHDLLQIIHFHSRSRTR----QIPPSILKSILWQIINGVAYLHEN 134

Human   146 WVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARH 210
            |::|||||||||::..    .|:|||.|:|..||...|:.|....|.||||.|||||||||||..
pombe   135 WIMHRDLKPANIMITA----TGKVKIGDLGLGRLIRDPILPFYSSDRVVVTIWYRAPELLLGAHD 195

Human   211 YTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSN----PFHHDQLDRIFSVMGFPADKDWEDIR 271
            ||.|||:||||||:.|:|...|:|  :.::||..:    ||...|:.||..::|.|.::.|..::
pombe   196 YTPAIDVWAIGCIYGEMLALSPLF--KGDEIKMEDKKVVPFQSTQMLRIMELLGTPTEERWPGLK 258

Human   272 KMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQ 336
            ..|||  .|.......|.|:.|.::.:..|.: |.:...||.|:|..||..|||::|||:..:|.
pombe   259 NYPEY--YQLSSFEVRYWNNLLPQWYQTVKNR-DPQGLDLLMKMLQYDPKSRITAKQALEHVFFT 320

Human   337 EDPLPTLDVFAGCQIPYPKREFLNEDDPE 365
            .|.|.|...|....|.||:|. ::|||.|
pombe   321 SDKLWTTSPFLNQPIHYPERR-ISEDDSE 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK19	NP_055891.1	STKc_CDC2L6	18..335	CDD:270850	134/322 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	359..502		4/7 (57%)
srb10	NP_593389.2	STKc_CDK8_like	4..319	CDD:270834	134/322 (42%)