Protein Alignment IQSEC2 and SYT1

DIOPT Version :10

• Sequence 1: XP_006724642.1
• Gene: IQSEC2 / 23096
• HGNCID: 29059
• Length: 1520
• Species: Homo sapiens
• Sequence 2: NP_015420.1
• Gene: SYT1 / 856210
• SGDID: S000006299
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 787
• Identity: 139/787 - (17%)
• Similarity: 252/787 - (32%)
• Gaps: 292/787 - (37%)

Human   285 GSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSK 349
            ||::||.:|.......||                   .|:.|.|.:|..:    ..:::::
Yeast    28 GSNVSTGIDKLRESESYR-------------------SPFLQLAEIQEHT----NNDDDKL---- 65

Human   350 ALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAA------------------------------- 383
               |..|.....:..|:..:.||.|...|:.|:|
Yeast    66 ---DVKECEPTKKHSKLSRIRRKMGRLDLNFRSANEKGSEDDEILVAQHLRNGQDPEEMPFKSEN 127

Human   384 --------------RTIQTAFRQYRMNKNFER---------LRSSASESRMSRRIILSNMRMQFS 425
                          |...|:.....:.:|.:.         |....|.:|:||
Yeast   128 NIDSIEKVPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSSNRLSR------------ 180

Human   426 FEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGG--SCGGGIDGGGSSVTTSGEFSND 488
              :|.|:|.|..|.|               .||...||...  |....:   |||...|..|:..
Yeast   181 --DYRKSQEPTLFNG---------------DRLVPTLPTVSRISTSSSV---GSSTAASRYFNPS 225

Human   489 ITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLD 553
            ...:..|.|....|:..:...|:      |:...|      :.|..:||::.|...|........
Yeast   226 KRAVVASSSSSSSSIKFNSLHAI------PLDATP------QIELAKQQDEISKRRFGRRRSRTV 278

Human   554 DTVPQQSPERLPSTEPPPQGRPEFWAPAP-LPPVPPPVPSGTRED--GSREEGTRRGPGCLECRD 615
            |.....:.......:||       .:|:. :..:.....:...:|  |||.
Yeast   279 DVFDYINKNNTAKNKPP-------LSPSSFIRTIDEKNTNSLMQDPMGSRG-------------- 322

Human   616 FRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVH--RQLVYEADGCS---------PHGTLKHKGP 669
                    |||    |.|:::..:|.....:.|  .|::..:...|         ...:::.:|.
Yeast   323 --------PLL----PDDANIISNDTDGAEASHPDHQVLSRSRSQSTSFVQGKGGKRKSIEDEGY 375

Human   670 PGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESS 734
            ..:..:||                       |:||:.|                       ..:.
Yeast   376 HNKLGLPH-----------------------GSGPTSV-----------------------YNNK 394

Human   735 SNSNETINCSSGSSSRDS-----------LREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRH 788
            ||:|.||   :|.|.|.|           ||....:...:|..|::               |:..
Yeast   395 SNANSTI---TGMSRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQQ---------------QQLQ 441

Human   789 YRIGLNLFNKKPEKGIQYLIERGFLSDT---------PVGVAHFILERKGLSRQMIGEFLGNRQK 844
            .::.::|.:..|....::       ||:         |.|             :.||..|..:..
Yeast   442 QKLDVSLEDLPPVPAPEF-------SDSCKDFLIKLAPYG-------------KFIGIILTEKDD 486

Human   845 QFNRDVLDCVVDE-MDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQ-- 906
            :|.::.|:.::.. .:|.:..||.||||....:.:..|.|:::|||.|||..|.....:..::
Yeast   487 EFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKG 551

Human   907 ----FRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRG--VDNGEDIPRDLLVGIY 965
                :.|.|.::.:||::::|:||.::|:.|:  ||...||:..:..  ...|.:||..:|...|
Yeast   552 IECPWSNADQVYFIAFSLLMLHTDYFNPNNKS--KMTKHDFVDLVHNDKYSGGNEIPMAVLTYFY 614

Human   966 QRIQGRE 972
            :.:..:|
Yeast   615 ENVTAKE 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC2	XP_006724642.1	ATG16	<23..>64	CDD:462536
		Sec7	785..973	CDD:460178	47/206 (23%)
		IQ_SEC7_PH	995..1124	CDD:465120
		KLF1_2_4_N	<1350..1457	CDD:425360
SYT1	NP_015420.1	Sec7	443..622	CDD:214569	46/201 (23%)