Protein Alignment IQSEC2 and siz

DIOPT Version :10

• Sequence 1: XP_006724642.1
• Gene: IQSEC2 / 23096
• HGNCID: 29059
• Length: 1520
• Species: Homo sapiens
• Sequence 2: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1555
• Identity: 460/1555 - (29%)
• Similarity: 644/1555 - (41%)
• Gaps: 451/1555 - (29%)

Human     6 GPPGGPGSESPNRA--------------------------VEYLLELNNIIESQQQLLETQRRRI 44
            |..||||..:...|                          |:.||..||.:.:          :|
  Fly    38 GNQGGPGGSAGGVAPPGPVSLPLPLSINMPHHHVHAMPYNVDELLRENNALHA----------KI 92

Human    45 EELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQ--- 106
            :||..:.|:|..|..:||.|  |...||.|.|....|:..::| .:....||:   ||..:|
  Fly    93 KELSLERDRLLCEVSNLRLE--LDMSELKRLPVDLDDNFPQKS-LERSGSTQY---ELAGAQQPG 151

Human   107 --------------------------FHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTT 145
                                      .|.::..:.||    |.|:.:.||:.::    ||
  Fly   152 SANASTCTDSGSVGGYVYLQNHYAPGAHSSSAAINYP----AQQHPQMVYQIQQ----YP----- 203

Human   146 GYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGAS 210
                      .||...:...|.:::...:.|..|        |......|.........|.
  Fly   204 ----------TCHQQQQQQHLQQQQHLHQTGAGH--------YMQVTATGGGQYHHHHMLH---- 246

Human   211 RSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVRSTASHTLHQYCCPTQVLDSMKLTPSGR-- 273
                   |.||                             |..|.               .|.
  Fly   247 -------GHGH-----------------------------HAHHH---------------GGAVV 260

Human   274 LAESSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALR 338
            :|.|.| |...||..::.:.....|...:.:....:|...||
  Fly   261 IAGSGV-GTGLGSGATSVIMQHQQQQQQQQNMHKKNSIRNGG----------------------- 301

Human   339 KQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLR 403
                :.:||::|.| :||||.||.:|::|:||||||| ..:|.||.|||.|||.|.|.|.|..:.
  Fly   302 ----DVLKRTRAQS-AYELSQDLLEKQIELLERKYGG-VRARNAAVTIQRAFRHYMMVKKFASIT 360

Human   404 SSA-SESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDE------------------GA 449
            :.| :|.|:|||::::  .......|...:.:.||.....:.|.|                  ..
  Fly   361 AMAKAEKRLSRRMVVT--ASSLGLAEEGASSSSAYGSATESQLTEQQQQQQAQQQQQPRVTIMAG 423

Human   450 MAGARSHRLERGLP--------------------YGGSCGGGIDGGGSSVTTSGEFSNDITEL-- 492
            .|||.|..|.|..|                    ..|:....|  ..|:|:||...|:....|
  Fly   424 PAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASI--SSSTVSTSALASHPHVNLLH 486

Human   493 --EDSF------------------SKQVKSLAESIDEALNC---HPSGPMSEEP--GSAQLEKRE 532
              |..:                  |....|.|.|.|.:||.   :.||.....|  .:||:..|.
  Fly   487 AAEPHYYNAQALPQGAAYYTSYHGSPHDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRP 551

Human   533 -------------SKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLP 584
                         |.......|.:..|       ..||.:.|:|..|.....|.:...     |.
  Fly   552 KGGSTTPTPSCSGSTGSGSGGSGSGSS-------KKVPPEVPKRTSSITAQQQTQLLL-----LQ 604

Human   585 PVPPPVPSGTREDG---SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPP-SDSSVDLSDR---S 642
            ...||.||..|.:|   :.|.|:                    |.:::.. |||||..::|   |
  Fly   605 RQTPPPPSLLRTNGLCKTAENGS--------------------LTSVQSSGSDSSVTSAERNLNS 649

Human   643 DRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGT---GP 704
            |.||....        ||| |.|.    |.|....:.:....            |.::|.   |.
  Fly   650 DLGSDRSN--------SPH-TWKR----GTALNSSQQFSTHS------------ADSAGAVSGGG 689

Human   705 SGVAGGRRLGKCE----AAGENSDGG----DNESLESSSNSNETINCSSGSSSRDSLREPPATGL 761
            .|||||..:...:    .|...:.||    |:.::.|.:::.:..........:..|:...|...
  Fly   690 VGVAGGAGVYAAQMQAAVAAATAAGGMPPADDHAISSHTSAAQYEQHEQQQHEQQQLQAAAAAAG 754

Human   762 CKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILE 826
            ..|.|:.            ::.:::|.||:|||||||||||||.|||.||||.:||.|||.|::.
  Fly   755 VAQNYKM------------SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLIT 807

Human   827 RKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEA 891
            |||||||||||:|||.|.|||..||.|...|:|.|...:|.||||||::.|:.|||||:|||:|.
  Fly   808 RKGLSRQMIGEYLGNLQNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEI 872

Human   892 FSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDI 956
            ||||||.||..:|.:.|:.||||:||||||:||||:::|::|.||:|:::||||||||:|:..||
  Fly   873 FSQRYCECNADIVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDI 937

Human   957 PRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQR 1021
            .:|:|:|||.|::..|.:...|||:||..|:..||||||.|:||||||||.|:|||:||.|:.:|
  Fly   938 DKDMLMGIYDRVKSDEFKPGSDHVTQVMKVQATIVGKKPNLALPHRRLVCYCRLYEIPDVNKKER 1002

Human  1022 LGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGE 1086
            .|:|||||||||||||:||||.|||..|||:||.||||....:.|.....|.|.|:|...|.|
  Fly  1003 PGVHQREVFLFNDLLVITKIFSKKKTSVTYTFRNSFPLCGTVVTLLDMPNYPFCIQLSQKVDG-- 1065

Human  1087 RKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGT 1151
             |:||.|||.:..||.:|..||:|||:|:.|||..|:|:|||:||. .|..|  ||.|::..:|.
  Fly  1066 -KILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKS-ARNRA--PGNAENRDSGV 1126

Human  1152 M------------ARSSLEDTYGAGDG---LKRGALSSSLRDLSDA---GKRGRRNSVGSLDSTI 1198
            .            :::|.|....:.|.   |||.|||:||.|:.:.   .|..||.|||||||.:
  Fly  1127 ADVEVCPCPYQQGSQASGEQAPNSADNSQQLKRSALSNSLLDMHEQFGNEKPQRRGSVGSLDSGM 1191

Human  1199 EGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASAS 1263
            ..|..|:.                  .|.....|:::...:...:...|..|.|||      :|:
  Fly  1192 SISFQSTT------------------TSSASRENAAAIAAAANAAAAAKMRFNMPP------TAA 1232

Human  1264 SSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQ- 1327
            .::.|:.:                ..|..|:   ..||.:.|....|   |:..||..|....|
  Fly  1233 IATPSNVY----------------AAPGMQA---YTHANFVQQSQAA---YMLQQQQMLQQQAQM 1275

Human  1328 ------QPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGG 1381
                  |.....|..:.....|.|.|:        .|.:|       ||..:|.|....|
  Fly  1276 QAQAQAQAQAQAQAQAQAQAQAQAQPL--------TGRIP-------GRERKASRTDENG 1320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC2	XP_006724642.1	ATG16	<23..>64	CDD:462536	12/40 (30%)
		Sec7	785..973	CDD:460178	116/187 (62%)
		IQ_SEC7_PH	995..1124	CDD:465120	74/128 (58%)
		KLF1_2_4_N	<1350..1457	CDD:425360	7/32 (22%)
siz	NP_730594.1	Sec7	766..954	CDD:460178	116/187 (62%)
		PH_IQSEC	981..1108	CDD:270128	75/129 (58%)