Protein Alignment IQSEC2 and bris-1

DIOPT Version :10

• Sequence 1: XP_006724642.1
• Gene: IQSEC2 / 23096
• HGNCID: 29059
• Length: 1520
• Species: Homo sapiens
• Sequence 2: NP_500420.3
• Gene: bris-1 / 177142
• WormBaseID: WBGene00019726
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 859
• Identity: 248/859 - (28%)
• Similarity: 355/859 - (41%)
• Gaps: 263/859 - (30%)

Human   355 YELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSN 419
            |:||.:|..:||::|||:|||..|:.|||..||.|:|:|.:.|.:..:|..
 Worm    22 YQLSDELALRKVQVLERRYGGMQLAHRAATVIQRAWREYCIMKQWMVIRHK-------------- 72

Human   420 MRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGE 484
                              .:..|..||      ||             ||         |:.|..
 Worm    73 ------------------HDTIPDHLD------AR-------------CG---------VSNSQR 91

Human   485 FSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLP 549
            ....:|      |:...||                     ||||        :.|.:|.|
 Worm    92 NELSLT------SRYATSL---------------------SAQL--------RIDRAARS----- 116

Human   550 LYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDG--SREEGTRR-GPGCL 611
                 |...:||                  |:|.|||...:.:....|.  |...|.|| |....
 Worm   117 -----TTLDRSP------------------PSPAPPVLVNLQNSNMIDSLMSPRLGNRRFGAAAS 158

Human   612 ECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIP 676
            .|..   .||.|....:..|..|.|:
 Worm   159 RCAP---AAAELTSTEVWLPRPSLVN--------------------------------------- 181

Human   677 HRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETI 741
              |.||.....|                       ||.|            :...|.|.:||
 Worm   182 --HNPAHSNSLP-----------------------RLDK------------HRVHERSESSN--- 206

Human   742 NCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQY 806
                  ..:.|..:||     :|...:|               ::|.|||.||.||||||:|:|.
 Worm   207 ------GRKKSEVKPP-----RQMTDQE---------------RKRQYRIALNFFNKKPERGVQL 245

Human   807 LIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRK 871
            |...||:.::|..:|..:..|:|||:.||||::|.....::..||......:|...:::|.||||
 Worm   246 LTAWGFVKNSPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRK 310

Human   872 FQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNP-DTIFILAFAIILLNTDMYSPSVKAE 935
            ......:..||:|::|:|:||:..|...||.....:|.. |||.:|:||||:||||::||:||
 Worm   311 AMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVK-- 373

Human   936 RKMKLDDFIKNLRGVD------NGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGK- 993
            ::|...||:|||||.|      |||||.|..|.|||.||:..||:..||||:|||.|:|.||||
 Worm   374 QRMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKD 438

Human   994 KPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILV---TYSFRQ 1055
            ||.|:...|||||.|:|.:|.||.:.|.....:|:||||||::||.|..::....:   ||:.:|
 Worm   439 KPRLTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQ 503

Human  1056 SFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK 1120
            ...|:..|:..||...|:||:.:  ..|..::   |.|||.:.:||..|.:|:.|||.|..|||:
 Worm   504 WTLLLGAHVTEFQRGQYEFGLTI--TCPNKDK---IHFNARNFEDRCHFVADVTESIREATEMEQ 563

Human  1121 YRVESELEKQ-KGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGK 1184
            .|:|.|:|:. ...:||:..:..|..|........:....:.|:.:....|..:||.
 Worm   564 VRLEMEMEQHTTTTIRPDNQRDSGLPDMDESMKLSNGSNSSAGSSNSSTNGVNNSSF-------- 620

Human  1185 RGRRNSVGSLDSTI 1198
              ||.|..||||.:
 Worm   621 --RRLSFNSLDSGV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC2	XP_006724642.1	ATG16	<23..>64	CDD:462536
		Sec7	785..973	CDD:460178	84/194 (43%)
		IQ_SEC7_PH	995..1124	CDD:465120	50/131 (38%)
		KLF1_2_4_N	<1350..1457	CDD:425360
bris-1	NP_500420.3	Sec7	224..417	CDD:238100	84/194 (43%)
		PH_IQSEC	445..573	CDD:270128	51/132 (39%)