DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF1B and Klp98A

DIOPT Version :9

Sequence 1:NP_001352880.1 Gene:KIF1B / 23095 HGNCID:16636 Length:1816 Species:Homo sapiens
Sequence 2:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster


Alignment Length:1388 Identity:395/1388 - (28%)
Similarity:633/1388 - (45%) Gaps:346/1388 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     4 ASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPK--NPKEAPK----SFSFDYSYWSHTSP 62
            :|:|||||||||||||...:::.|::|:...|.::.|:  :.::|.:    .|:|||||||..: 
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65

Human    63 EDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELF 127
            |||.||:|.:||:|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||::|||||
  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128

Human   128 EKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLLGPYVEDLSKLAVTSYTD 191
            .::.........|....||:|||.|||:|||..::.|: ||||||..||||||:||:.||:.:.:
  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193

Human   192 IADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERAD 256
            |.:.:..||..||.|:||||:|||||||:|||.|.|....|:  :.:|.||||.||||||||||:
  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMND--MPSETVSKIHLVDLAGSERAN 256

Human   257 STGAKGTRLKEGANINKSLTTLGKVISALAEVDN----------CTSKSKKKKKTDFIPYRDSVL 311
            :|||.|.||||||:|||||.|||.|||||||...          .|:.:...|:..:||||||:|
  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321

Human   312 TWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEV 376
            ||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.||:|||:||:
  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386

Human   377 TRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTS 441
            .:||.:|    .|||..:.|.:        |.|.|.|.                           
  Fly   387 NKLKSML----AGDIHSLQPSL--------KVLADLQK--------------------------- 412

Human   442 SPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMERE 506
                                         :||.|::         |.|.|.||.:..::|..|::
  Fly   413 -----------------------------KEAQEKV---------LTEEWTEKWKVAQSILQEQK 439

Human   507 ALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVL 571
            :|      .:|:.|  :||....:.|||:.::.| :.:...||.:|:|.||:|..||:..|||.|
  Fly   440 SL------GLRKSG--VGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIEL 495

Human   572 SGAHIKEEHC-IFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFN 635
            :|..|:.:|| ||    ...|  :|||.|...::.:||...:.:|.|:..|:.|::|:.::||||
  Fly   496 AGDGIRAQHCSIF----LKGG--VVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFN 554

Human   636 HPEQA-------------------------------------------RAEREKTPSAETPSEPV 657
            :|.:|                                           |.||:..|......:..
  Fly   555 NPAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDP 619

Human   658 DWTFAQRELLEK----------QGIDMKQEMEKRLQEM-EILYKKEKEEAD-----------LLL 700
            :.....|::|:.          :.:.|..:.:.::::: |.|.:.|:||.|           |:.
  Fly   620 ELQDENRKILDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIA 684

Human   701 EQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDL 765
            .:..|.:|...:.:|..:..|.::|..|:.:.::.:              |.::.:.:...|:|.
  Fly   685 RKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRD--------------FSEYVAKELQELQDC 735

Human   766 --LWGNAVYLKEANAISVELKKKVQ-----FQFVLLTDTL------YSPLPPELL---------P 808
              |....:.::|...::.||..:|.     |....:.||:      ...|..::.         .
  Fly   736 GKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERILNAST 800

Human   809 TEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKL-----------------KQRLDLMREMY 856
            |::.|..|      |::.::.|           ||:|                 ||.:.|  ::.
  Fly   801 TKIAKVDE------TMLEIQAQ-----------LERLRLERAESEAESQAMRAKKQNMKL--QLG 846

Human   857 DRAGEMASSAQDESETTVTGSDPF--YDRFHW----FKLVGSSPIFHGCVNERLADRTPSPTFST 915
            :::  |::|........|:.||.:  .|.||.    ..||.|..|..|       .::|....|.
  Fly   847 NKS--MSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSSPTITEG-------QQSPLSNCSC 902

Human   916 ADSDITELADEQQDEMEDFDDE-AFVDDAGSDAGTEEGS-DLFSDGHDPFYDRSPWFILVGRAFV 978
            ...|  |..|.::|::....:| :....||..:|:..|| .:...|..|....|...|:....  
  Fly   903 DAED--EAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSG-- 963

Human   979 YLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGS------GIRQSGTAKISFD 1037
                    |.|..|...:.:.|.:..:    .||:...:|  |.||      | |.|..|:    
  Fly   964 --------VCLDSRNQAILQNGHLNNY----KQAVRTSDE--DTGSCSSCELG-RHSDVAR---- 1009

Human  1038 NEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISR------------INDLDLKS 1090
             .|............:..|.::.|.....:.|..|.|...:::.|            :.||:..:
  Fly  1010 -PYCPLHSLRRKIAAQKALIMKNLETDLNKAQLDEHIADLQDLQRRYIQMEQEMLQSVQDLEAHA 1073

Human  1091 STLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIF-------CQFNFLHRHDE 1148
            ....|.:..||       ...:|.|:. .|.:|:..:.:....:.|:       |.........|
  Fly  1074 QCCADERSGME-------RQYELASSI-MRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGE 1130

Human  1149 AFSTEP---LKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPL---HLQGQ 1207
            .|.|.|   ::..|:.:    ::...:.:.:.:..::.::.       :..:::..|   |..|.
  Fly  1131 HFITIPSFVMRGAGKQT----HYEYEVRIALPDGKLNILRR-------YSRFRELHLCMKHCYGA 1184

Human  1208 ELNSPPQPCRRFFPPPMPLSKPV 1230
            ::::.|.|.|..|...   |:||
  Fly  1185 KISALPFPRRELFASN---SEPV 1204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF1BNP_001352880.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 198/373 (53%)
Interaction with KBP. /evidence=ECO:0000269|PubMed:16225668 270..350 53/89 (60%)
Kinesin_assoc 358..555 CDD:318424 44/196 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..450 0/18 (0%)
FHA 532..636 CDD:238017 38/104 (37%)
Prefoldin 662..717 CDD:324325 13/76 (17%)
KIF1B 845..892 CDD:315155 14/69 (20%)
DUF3694 1266..1413 CDD:315198
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1617..1660
PH_KIFIA_KIFIB 1697..1799 CDD:269939
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 198/373 (53%)
KISc 3..371 CDD:214526 198/372 (53%)
Kinesin_assoc 370..478 CDD:292801 44/193 (23%)
FHA 456..555 CDD:238017 38/105 (36%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 14/88 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.