Protein Alignment KIF1B and Klp61F

DIOPT Version :9

• Sequence 1: NP_001352880.1
• Gene: KIF1B / 23095
• HGNCID: 16636
• Length: 1816
• Species: Homo sapiens
• Sequence 2: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Alignment Length: 1054
• Identity: 257/1054 - (24%)
• Similarity: 447/1054 - (42%)
• Gaps: 266/1054 - (25%)

Human     2 SGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEA----------PKSFSFDYSY 56
            |..:::|.|||||.||||     :||     .|..:::...|:|.          .|.|:||.|:
  Fly    16 SNQNIQVYVRVRPLNSRE-----RCI-----RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF 70

Human    57 WSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK---------QE 112
                .||    :.|..||:.:...::.....|||..:|||||||.||::||:|.         ::
  Fly    71 ----GPE----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127

Human   113 ESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--G 175
            :|..||||:....||:::.   ..|:.|::.:||:|:|.|.:.|||:..:...:|:.:....  .
  Fly   128 DSDIGIIPRALSHLFDELR---MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189

Human   176 PYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTE- 239
            ..::.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||.    |..|..:..|
  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGED 250

Human   240 --KVSKISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKT 301
              |:.|::||||||||.....| .||.|::|..|||:||.|||:||:||.:            :.
  Fly   251 MLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------------RA 303

Human   302 DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNA 366
            ..:|||:|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....
  Fly   304 PHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTK 368

Human   367 KLV-RELKEEVTRLK-DLLRAQGLGDIIDIDPLIDDYSGSGS-----------------KYLKDF 412
            |.| :|..||:.:|| ||:.|:....|.    |.::..|..:                 |.|||.
  Fly   369 KTVLKEYTEEIDKLKRDLMAARDKNGIY----LAEETYGEITLKLESQNRELNEKMLLLKALKDE 429

Human   413 QNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERL 477
            ..||.:.           ||..||..:..:            ..:...:|.:::|.|      .|
  Fly   430 LQNKEKI-----------FSEVSMSLVEKT------------QELKKTEENLLNTKG------TL 465

Human   478 KESEKIIAELNETWEEK-------LRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLV 535
            ..::|::.:....::||       ::..:.:..:.:.:||...:|..:.....|....::.
  Fly   466 LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRE---- 526

Human   536 NLNEDPLMSECLLYYIKDGITRVGQADAERRQD-IVLSGAHIKEEHCIFRSERSNSGEVIVTLEP 599
                           :.:.|.|......:|.|| :.:.|..:.    :::.:::...|
  Fly   527 ---------------LDEKIRRSCDQFKDRMQDNLEMIGGSLN----LYQDQQAALKE------- 565

Human   600 CERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQR 664
             :.|:..||...|||.:.|.|...|.|.|....: :..:|.....:........|:.....|..:
  Fly   566 -QLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQ-SLQDQTNLHNKLIGEVMKISDQHSQAFVAK 628

Human   665 --ELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQ---KQVETR--S 722
              |.:::|.:.|.:|::..||.:|...::.|...|.:.|:.....:|.||:::   ||:..:  .
  Fly   629 LMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQ 693

Human   723 LAAETTEEEEE----EEEVPWTQHEFELAQW--AFRKWKSHQFTSLRDLLWGNAVYLKEANAISV 781
            |.|.:..:.||    :||:   .:|..|||.  |..:....|...:::|...|::      ::||
  Fly   694 LGAMSLPDAEELQNLQEEL---ANERALAQQEDALLESMMMQMEQIKNLRSKNSI------SMSV 749

Human   782 ELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKLK 846
            .|.|..:                    :.:.:.|            .:.|:|:|...|
  Fly   750 HLNKMEE--------------------SRLTRNH------------RIDDIKSGIQDY------- 775

Human   847 QRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYD---------RFHWFKL-----------VG 891
            |:|.:         |.:.|||.|..:.:.......|         :.|...|           ||
  Fly   776 QKLGI---------EASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVG 831

Human   892 SSPIFHGCVN----------ERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDA--G 944
            |..:.|..|.          |.:.::|        :.::.::.|.:|..:.: |.:.|:..|  .
  Fly   832 SVRVHHNQVEIICQESKQQLEAVQEKT--------EVNLEQMVDARQQLITE-DRQRFIGHATVA 887

Human   945 SDAGTEEGSDLFSD 958
            :|. .:|.:..||:
  Fly   888 TDL-VQESNRQFSE 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF1B	NP_001352880.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	136/381 (36%)
		Interaction with KBP. /evidence=ECO:0000269|PubMed:16225668	270..350		36/79 (46%)
		Kinesin_assoc	358..555	CDD:318424	35/222 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..450		4/18 (22%)
		FHA	532..636	CDD:238017	18/104 (17%)
		Prefoldin	662..717	CDD:324325	13/59 (22%)
		KIF1B	845..892	CDD:315155	11/66 (17%)
		DUF3694	1266..1413	CDD:315198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1617..1660
		PH_KIFIA_KIFIB	1697..1799	CDD:269939
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	137/384 (36%)
		Kinesin	25..356	CDD:278646	133/367 (36%)
		Microtub_bind	923..>1009	CDD:290642

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910