DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF1B and Khc-73

DIOPT Version :9

Sequence 1:NP_001352880.1 Gene:KIF1B / 23095 HGNCID:16636 Length:1816 Species:Homo sapiens
Sequence 2:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster


Alignment Length:1965 Identity:564/1965 - (28%)
Similarity:831/1965 - (42%) Gaps:588/1965 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINP----KNPKEAPKSFSFDYSYWSHTS 61
            |:...:||||||||||.||...::|||::|:...|.:.||    |..::.||:|:||:.::| .:
  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64

Human    62 PEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEEL 126
            |||..||||..|::.:|:.:|.:||:|||.|||||||||:||||||||.||..  ||||:||::|
  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--GIIPRLCDQL 127

Human   127 FEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190
            |..|.:....|:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192

Human   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERA 255
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257

Human   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318

Human   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRA 385
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|  
  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML-- 381

Human   386 QGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSS 450
                                          ||                     .|.||       
  Fly   382 ------------------------------KH---------------------ATGSP------- 388

Human   451 QVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVA 515
                  |..:|             ::|.|||.::.::::||||||.|||.|:.||:..|.:||::
  Fly   389 ------VGDVQ-------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGIS 434

Human   516 IREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEH 580
            ::..    |:...|...:|||||.||.::|.|:||:||.....|:..:.::.||.|||..|:.||
  Fly   435 VQAS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEH 495

Human   581 CIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAERE 645
            |:...|.|.     :.:||.:.:..:|||....:...|::|:||:.|.:|.||.|.|:...... 
  Fly   496 CVITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM- 554

Human   646 KTPSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYES 709
            .....:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.
  Fly   555 CASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYER 613

Human   710 KLQALQK---------------QVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQF 759
            :.|.|:.               .:....:...|...:...|:  |.|...|:.:.:..:.|:   
  Fly   614 QFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEK--WAQERDEMFRRSLGQLKT--- 673

Human   760 TSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTV 824
                |::..|:: ::|||.::.|::||.:|..     ||..| |..|.|..........|     
  Fly   674 ----DIMRANSL-VQEANFLAEEMEKKTKFSV-----TLQIP-PANLSPNRRRGAFVSEP----- 722

Human   825 VAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKL 889
             |:.|:...:| :..|::|||:.:|..|||||          |:..|..:.|.|           
  Fly   723 -AILVKRTNSG-SQIWTMEKLENKLIDMREMY----------QEHKERVLNGLD----------- 764

Human   890 VGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSD 954
                                                         :|.|                
  Fly   765 ---------------------------------------------EDNA---------------- 768

Human   955 LFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEA 1019
               ...||||:......|:|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.||     
  Fly   769 ---KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIA----- 825

Human  1020 PDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRIN 1084
                                    .......|..|        :.|..|.|.:....|       
  Fly   826 ------------------------GQMPQDRMCES--------VSESSGDSRDEYDDP------- 851

Human  1085 DLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYAD-IFCQFNFLHRHDE 1148
                           ::..|.:|          |.|||:..|||:....:: :|||:.| ..|.|
  Fly   852 ---------------VDPTSNQI----------TCRVTIKCASGLPLSLSNFVFCQYTF-WGHQE 890

Human  1149 AFSTEPLKN-----NGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQE 1208
              ...|:.|     :.:.....|.|.|:..|.|.|.|:::.....:..||:||........:|.|
  Fly   891 --MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWE 953

Human  1209 LNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVD 1273
            :.......|........||:.:.                      :|.||.||...|||.|..|.
  Fly   954 VEQQQAKARSLVDRWAELSRKIE----------------------LWVEIHELNDNGEYSPVEVT 996

Human  1274 HTAGLPCQGTFLLHQGIQRRITV------------------------------------------ 1296
            :...:...|.:.|.||.|||:.|                                          
  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEE 1061

Human  1297 --TIIHEKGSELHWK-------DVRELVVGRIRNKPEVDE-----------------AAVDA--- 1332
              |::.||.||...:       .::.|:....:|:.|.:.                 ..|.|   
  Fly  1062 DLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGS 1126

Human  1333 --------------------ILSLNI----ISAK-------------YLKSSHNSSRTFYRFE-- 1358
                                :|.||:    :||:             .|...|  ...||..:  
  Fly  1127 GIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEH--GHKFYTLQIL 1189

Human  1359 ----------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPA----VITKDVCM--- 1406
                      |.||||:|:|..|||||...|::|:.|...:.|.|   ||    |:.|.:.:   
  Fly  1190 QHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSH---PAPMDLVLRKRLSINIK 1251

Human  1407 ---VFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYEL----SLCKMSDTGSPGMQRRRRKI 1464
               ....|..|....|...:::.||.:....||......||    ||.:::.:|.          
  Fly  1252 KGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGD---------- 1306

Human  1465 LDTSVA--------YVRG----EENLAGWRPRGDSLILE----HQWELE---------------- 1497
             |.|.:        |.||    |..|...|.|.:..:.|    |...|.                
  Fly  1307 -DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRF 1370

Human  1498 --KLELLHEVEKTRHFL-LLRERLGDSIP---------------------KSLSDSLSPSLSSGT 1538
              .:|.|..|.::..|. |....||:...                     |..||. ||..:.|.
  Fly  1371 DASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-SPGKAFGI 1434

Human  1539 LSTSTS-ISSQISTTTFESAI--------TPSES---SGYDSGDIESLVDREKELATKCLQLLTH 1591
            .|.:|| :.....||..|..:        .|.:|   |.| :.:.|....:.|.:||:.....:.
  Fly  1435 ASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEY-AAEYEQERQQNKSMATRSRLTASK 1498

Human  1592 TFNREFSQV----------HGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSL-----VDS 1641
            |.: .|..|          :.|.::..:..::.:......||.||...:.:.:|.:|     ...
  Fly  1499 TMD-SFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASM 1562

Human  1642 RSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNEFLNLVP--DIEEIRPSSVVSK 1704
            ||.|:|: ||:.: |.:|..|...|.::              |.||..:|  .|:| :|.....|
  Fly  1563 RSMSIDE-TPDFD-RVNSNSPPNRQARV--------------NPFLKDMPKAKIQE-QPEQQAKK 1610

Human  1705 --KGYLHFKEPLYSN 1717
              :.:.|..|.|.|:
  Fly  1611 LQEAFTHPLEQLESS 1625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF1BNP_001352880.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 221/361 (61%)
Interaction with KBP. /evidence=ECO:0000269|PubMed:16225668 270..350 54/79 (68%)
Kinesin_assoc 358..555 CDD:318424 56/196 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..450 3/18 (17%)
FHA 532..636 CDD:238017 38/103 (37%)
Prefoldin 662..717 CDD:324325 15/70 (21%)
KIF1B 845..892 CDD:315155 11/46 (24%)
DUF3694 1266..1413 CDD:315198 53/276 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1570 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1617..1660 13/47 (28%)
PH_KIFIA_KIFIB 1697..1799 CDD:269939 6/23 (26%)
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 221/361 (61%)
KISc 6..359 CDD:214526 221/359 (62%)
Kinesin_assoc 356..468 CDD:292801 54/194 (28%)
FHA 446..546 CDD:238017 38/104 (37%)
KIF1B 741..786 CDD:289208 18/129 (14%)
DUF3694 <1196..1252 CDD:289256 21/58 (36%)
CAP_GLY 1786..1850 CDD:279625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

Return to query results.
Submit another query.