Protein Alignment ARHGAP26 and RGA1

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_014770.1
• Gene: RGA1 / 854294
• SGDID: S000005653
• Length: 1007
• Species: Saccharomyces cerevisiae
• Alignment Length: 691
• Identity: 143/691 - (20%)
• Similarity: 250/691 - (36%)
• Gaps: 177/691 - (25%)

Human    13 LDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLIS------------ALKNLSSAKRKFADSLN 65
            :|....|:.|.:...|.:...:.:.|::|:.:|:..            :..|.|...||.:.||:
Yeast   356 MDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLS 420

Human    66 --------EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEV-LITPLEKFRK 121
                    ..|.:..|..:::.::..|..:..     |..:|   .|.:|.|.. |.||......
Yeast   421 RRSKDLMINLKSRATGKQDSNVKLSPASKVTS-----RRSQD---LMRDNDSHTGLDTPNSNSTS 477

Human   122 EQIGAAKEAKKKYDKETEKYCGILE----KHLNLSSKKKES-----------QLQEADSQVDLVR 171
            ..|....:....|.:.|:.  |.|.    |...|..:|..|           |.....|.|.:.|
Yeast   478 LDILVNNQKSLNYKRFTDN--GTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYR 540

Human   172 --------------------QHFYEVSLEYVFKVQ-------EVQERKMFEFVE----PLLAFLQ 205
                                |::...|.:...|.|       |.|:..::|..|    |.|.  :
Yeast   541 TPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLD--K 603

Human   206 GLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTME- 269
            .:.|..|           :..||.|:::...::.|....|:.. ||.|||....|  |..|..|
Yeast   604 EIVTAEH-----------YLKQLKINLKELESQREELMKEITE-MKSMKEALRRH--IESYNSEK 654

Human   270 GYLYVQEKR-----------HFGTS-WVKHYCTYQRDSKQITMVPFDQ-KSGGKGGEDESVILKS 321
            ..||:....           ..|.| .|||..|....::......|.: .|..|...::|:  :.
Yeast   655 NKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSI--QG 717

Human   322 CTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWM---------EAMDGR-EPVYN-SNK 375
            .:...|:||.|         ..|.:::..:......||.:         |..|.| .|:.| :|.
Yeast   718 VSTNNTNSIVK---------SAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANM 773

Human   376 DSQSEGTAQLDS---IGFSIIRK--------------CIHAVET--RGINEQGLYRIVGVNSRVQ 421
            ....:|...||.   .|.|::.:              ||..:|:  ..:..:|:||..|....::
Yeast   774 GQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIE 838

Human   422 KLLSVLMDPKTASETET-DICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAK----LEN 481
            ::.......|....||| :|..|.::..:|..||.|||.||.|:..:|.....::..|    :||
Yeast   839 EIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMEN 903

Human   482 -----------------QESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLG 529
                             ..|..|.:.:::..||.::.::|::|..|:..|......|.||:.||.
Yeast   904 LPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLA 968

Human   530 VVFGPTLLRP---QEETVAAIMDIKFQNIVIEILIENHEKI 567
            :||.|.|:|.   :::    |:|:|.:|.::..:..|::.|
Yeast   969 LVFAPGLIRDFSGEKD----IIDMKERNYIVAFIFGNYKDI 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	48/272 (18%)
		BAR-PH_GRAF_family	267..371	CDD:269953	24/127 (19%)
		RhoGAP_Graf	364..563	CDD:239839	58/244 (24%)
		SH3	759..>790	CDD:473055
RGA1	NP_014770.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	803..1002	CDD:214618	48/202 (24%)