Protein Alignment ARHGAP26 and RGA2

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_010667.1
• Gene: RGA2 / 851985
• SGDID: S000002787
• Length: 1009
• Species: Saccharomyces cerevisiae
• Alignment Length: 506
• Identity: 118/506 - (23%)
• Similarity: 203/506 - (40%)
• Gaps: 146/506 - (28%)

Human   143 GILEKHLNLSSKK---KESQLQ---------EADS-QVDLVRQ---------HFYEVSLEYV-FK 184
            |.|.|..:|||:.   :.|.||         |.|| :||...:         :|.|::|..: ..
Yeast   567 GPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLD 631

Human   185 VQEVQ--ERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQN-TRNRFEGTRSEV 246
            |:|::  ::|:.:.||.|               .|||:      :|...:.| ||.:.:.:.|..
Yeast   632 VRELEGTKKKLLQDVENL---------------RLAKE------RLLNDVDNLTREKDKQSASSR 675

Human   247 ESLMKKMKENPLEHKTI----------------SPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDS 295
            |||  :.|||.....|:                ||......::...|.|
Yeast   676 ESL--EQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDH---------------- 722

Human   296 KQITMVPFDQKS-GGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRL 359
             |:..:...|:| ....|...::..|..:..|...:.       :.:..||.:   .||...:||
Yeast   723 -QVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVH-------DELPSPGKV---PLSPSPKRL 776

Human   360 WMEAMDGREPVYNSNKDSQ---SEGTAQLDSIGFSIIRKCIHAVETR--GINEQGLYRIVGVNSR 419
             ....||.. :|.|:..::   .:.|..:      |||.||..:|..  |:|.:||||..|..:.
Yeast   777 -DYTPDGSH-LYGSSLQARCAYEKSTVPI------IIRCCIDRIEKDDIGLNMEGLYRKSGSQTL 833

Human   420 VQK----------LLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQF----- 469
            |::          |.|..:.||..:....||.|      :.|.||.|||.||.|::.:..
Yeast   834 VEEIENEFAQNNSLHSDTLSPKLNALLNQDIHA------VASVLKRYLRKLPDPVLSFSIYDALI 892

Human   470 ----QRSFIKAAKLENQE-----SRVSEIHSLVHR--------LPEKNRQMLQLLMNHLANVANN 517
                ....|:...|.|.:     .:|: |:.:|.:        ||.:::::|::|..|:..|...
Yeast   893 DLVRNNQLIERLPLNNDKFLDSPQKVT-IYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRC 956

Human   518 HKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
            .::|||.:.||.:||.|:|:. ..:....|:|:|.:|.::|.::.|:..||
Yeast   957 SERNLMNLHNLSLVFAPSLIH-DFDGEKDIVDMKERNYIVEFILGNYRDIF 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	26/106 (25%)
		BAR-PH_GRAF_family	267..371	CDD:269953	16/104 (15%)
		RhoGAP_Graf	364..563	CDD:239839	61/235 (26%)
		SH3	759..>790	CDD:473055
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		RhoGAP	815..1002	CDD:214618	50/194 (26%)