Protein Alignment ARHGAP26 and arhgap10

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_001038715.1
• Gene: arhgap10 / 692277
• ZFINID: ZDB-GENE-060512-221
• Length: 764
• Species: Danio rerio
• Alignment Length: 794
• Identity: 412/794 - (51%)
• Similarity: 527/794 - (66%)
• Gaps: 72/794 - (9%)

Human     1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
            |||..||||:|.||||.||:.:|:|||||:||.:|||||.||||:||:|.|.||.|::|||..|.
Zfish     1 MGLHPLEFSECYLDSPAFRDKIKAHEAELEKTGRFIKELYKDGKNLINATKQLSLAQKKFAQCLG 65

Human    66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEA 130
            ||||:.||||:||||.||..|||||:..|||||::|..|:.|.:|.|:.|||.||||.:|:||..
Zfish    66 EFKFEYIGDAKTDDEKCIDESLQEFSLFLRNLEEQRDLMMRNITETLMKPLENFRKEHLGSAKAE 130

Human   131 KKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFE 195
            :|||:||||||...|||.||:|:||||.||||||..|:|:||||.|.|||||.|:||:||||.||
Zfish   131 RKKYEKETEKYYSSLEKLLNMSAKKKEPQLQEADVSVELMRQHFQETSLEYVCKLQEIQERKKFE 195

Human   196 FVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEH 260
            .|||:|||.|.:|||||.||||||||..:|..|.|:|||||||||||||||..|||::||:|.::
Zfish   196 CVEPMLAFFQTVFTFYHQGYELAKDFDHYKKALQINIQNTRNRFEGTRSEVFELMKRIKESPQDY 260

Human   261 KTISPYTMEGYLYVQEKR--HFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCT 323
            :..||.:.||||||||||  .||:||||.|.|:.::.|.:.|..|||:||||.||.|||.||||.
Zfish   261 RQTSPISSEGYLYVQEKRPPPFGSSWVKRYSTFVKEQKILHMKTFDQRSGGKLGETESVTLKSCV 325

Human   324 RRKTDSIEKRFCFDVEAVDRPG-VITMQALSEEDRRLWMEAMDGREPVYNSNK-DSQSEG-TAQL 385
            |:.||::::|||.|:|..|||| |:|:|||||:|.:.||.||.|:||:...|: .|:..| .|||
Zfish   326 RKTTDALDRRFCLDIEITDRPGTVLTVQALSEDDHKFWMHAMGGKEPMQCLNRTHSRERGIDAQL 390

Human   386 DSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICA--EWEIKT 448
            |.:|.|.::..|:|:|.||||:|||||:|||:|:||||||:::|.|:   ::.|:.|  :|::||
Zfish   391 DDVGISFVKNSINAIEARGINDQGLYRVVGVSSKVQKLLSLMIDEKS---SDIDLSANEDWDVKT 452

Human   449 ITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLAN 513
            ||||||.|||.||.|||.|:..:.||..||..:.||||..||.|||:||||||.:|.|:..||||
Zfish   453 ITSALKLYLRSLPEPLMTYELYKEFIVPAKSASPESRVQAIHCLVHKLPEKNRLVLSLVTKHLAN 517

Human   514 VANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTN 578
            ||.|.||||||||||||||||||:||||||||||||:||||||:|||||.|||||...|....:.
Zfish   518 VAANSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIEQHEKIFGDAPSSSPSL 582

Human   579 AQLHLSRKKSSDSKPPSCSERPLTLFH----TVQSTEKQEQRNSIINSSLESVSSNPNSILNSSS 639
            |...|| ..:..||..|...|||.:::    .:|:.....:...:.|.. .||.||     .|.|
Zfish   583 ATTPLS-APTRQSKRLSRQTRPLAVYNPQVLDIQTVSPSSESAGLCNDE-TSVGSN-----ESVS 640

Human   640 SLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAG 704
            |...|.:.:.|:.:....|..::.....:.....:.||...::|:|..|..
Zfish   641 SQSSNASGTPPEKSKNHHTTISTSLQEGTGICTATASWMNSASPASLTPVK-------------- 691

Human   705 FVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKA 769
                                           |.::....::|||:|      ...||||:|.|:|
Zfish   692 -------------------------------HGSVRTEKNKPEESV------TLMKAKAVYPCEA 719

Human   770 EHDSELSFTAGTVF 783
            ||||||||..|.:|
Zfish   720 EHDSELSFQVGAIF 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	134/205 (65%)
		BAR-PH_GRAF_family	267..371	CDD:269953	63/106 (59%)
		RhoGAP_Graf	364..563	CDD:239839	125/202 (62%)
		SH3	759..>790	CDD:473055	17/25 (68%)
arhgap10	NP_001038715.1	BAR_GRAF2	19..225	CDD:153319	134/205 (65%)
		BAR-PH_GRAF_family	267..373	CDD:269953	62/105 (59%)
		RhoGAP	367..566	CDD:470621	124/201 (62%)
		DUF5585	<578..>691	CDD:465521	26/119 (22%)
		SH3	710..763	CDD:473055	17/24 (71%)