Protein Alignment ARHGAP26 and arhgap42b

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: XP_021323547.2
• Gene: arhgap42b / 569534
• ZFINID: ZDB-GENE-120217-5
• Length: 883
• Species: Danio rerio
• Alignment Length: 895
• Identity: 424/895 - (47%)
• Similarity: 535/895 - (59%)
• Gaps: 124/895 - (13%)

Human     1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
            ||||.|||||..:|||.|||.||.||.|||:||||||||||||..||.||||||:|.:||:.||.
Zfish     1 MGLPTLEFSDSFVDSPDFRERLKCHEIELDRTNKFIKELIKDGHQLICALKNLSAAVQKFSQSLQ 65

Human    66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEA 130
            ||:|:||||||||||:.||:|.:||:.:|..:|:||.|:|:||.:|||||||:|||||||||||.
Zfish    66 EFQFECIGDAETDDEVNIAQSFKEFSKLLHTMEEERRRLIQNADDVLITPLERFRKEQIGAAKEG 130

Human   131 KKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFE 195
            |||:|||.|||...|:|||||||:||||.|||||:|:|..||.||:.|||||||:|:|||:|.||
Zfish   131 KKKFDKEAEKYYSTLDKHLNLSSRKKESALQEADAQIDRERQLFYDASLEYVFKIQDVQEKKKFE 195

Human   196 FVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEH 260
            |||||||||||||||||.|||||.||..:|.||..::|||||.|..|:.|||:||.:::....:.
Zfish   196 FVEPLLAFLQGLFTFYHEGYELAHDFEPYKQQLQFNLQNTRNNFLSTKQEVENLMNRVRSADQDQ 260

Human   261 KTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMV-----PFDQKSGGKGGEDESVILK 320
            |....:||||||||||||..|.:|.:|||||.:|::..:|.     |..:::|......|...||
Zfish   261 KPPGQWTMEGYLYVQEKRPLGCTWTRHYCTYDKDNQTFSMCNTEAKPAAKQNGVTSNPPEKFRLK 325

Human   321 SCTRRKTDSIEKRFCFDVEAVD-------------------RPGVITMQALSEEDRRLWMEAMDG 366
            ||.|||||||:||||||:|.|:                   |.|:||:|||||.:||||:|||||
Zfish   326 SCIRRKTDSIDKRFCFDIEVVERNTVYRGSLFRPLQFFFKSRHGIITLQALSESNRRLWLEAMDG 390

Human   367 REPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETR-GINEQGLYRIVGVNSRVQKLLSVLMDP 430
            :||:||.......:....|:..||:.:||||..||.| |:|..||||:.|:||:||||::.:..|
Zfish   391 KEPIYNLPAILSKKEETYLNETGFNFVRKCIQLVEVRAGLNTMGLYRVGGINSKVQKLMTTVFSP 455

Human   431 KTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHR 495
            |.||:.:.| ...|:.|||||.||.|||.|..|||.|:....|:.|.|.::|..||..:|:|||:
Zfish   456 KAASDLDLD-PDTWDNKTITSGLKNYLRCLSEPLMTYKLHSDFLMAVKSDDQNYRVCAVHALVHK 519

Human   496 LPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEIL 560
            ||:|||:||::|:.||.||:::.:.|:|||:||||:|||||:|.|||||||:|:|||||||:|||
Zfish   520 LPDKNREMLEILIKHLLNVSSHSESNMMTVSNLGVIFGPTLMRSQEETVAAMMNIKFQNIVVEIL 584

Human   561 IENHEKIFNTVPD------MPLTNAQLHLSRK---KSSDSKPPSCSERPLTLFHTVQSTEKQEQR 616
            |||.||||:..||      .||:..:...||.   .|...||.|.....|.|......|......
Zfish   585 IENLEKIFHQAPDPNVPLLQPLSRPESRRSRAIGLTSGPRKPRSLYTPSLCLADADSDTFSSSSG 649

Human   617 NSIINS--SLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPM 679
            ::.|.|  ||.|.||..||...:.||.|                 ....||.|.|.||.|.|
Zfish   650 STPIGSMDSLSSHSSEQNSSSKTCSSPQ-----------------HKDKPPFPGPRSPFSRS--- 694

Human   680 FSAPSSPMPTSSTSSDS------------SPVRSVAGFVWFSVAAVVLSLARS--SLHAVFSLLV 730
            .|.|..|..|||..|.|            ..:||.........|.:..|:|:|  |||....:..
Zfish   695 SSEPQGPAGTSSPDSSSREQDCPADESFRGNLRSTTAPTKAPHAQLNRSIAQSLRSLHLTEGVCK 759

Human   731 NFVPCHPNLH----------------------------------------------LLFDRPEEA 749
            :|.   .::|                                              |||:.|...
Zfish   760 SFA---GSVHSLACVDGSKSTTCLDLPPKALLRRKLDNNSSTNGYQRPGSVVAARALLFENPSAV 821

Human   750 VHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNAECPSASTAIFTAT 799
            .|....   |.|||:|:|:|||.:||||..|..|.|. .||.......||
Zfish   822 KHPPVG---RDAKAIYSCEAEHSNELSFPQGAHFSNV-YPSVEPGWLQAT 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	148/205 (72%)
		BAR-PH_GRAF_family	267..371	CDD:269953	63/127 (50%)
		RhoGAP_Graf	364..563	CDD:239839	106/199 (53%)
		SH3	759..>790	CDD:473055	16/30 (53%)
arhgap42b	XP_021323547.2	None