Protein Alignment ARHGAP26 and arhgap42a

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: XP_021324560.1
• Gene: arhgap42a / 566275
• ZFINID: ZDB-GENE-030131-8077
• Length: 900
• Species: Danio rerio
• Alignment Length: 896
• Identity: 423/896 - (47%)
• Similarity: 550/896 - (61%)
• Gaps: 109/896 - (12%)

Human     1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
            ||||||||||..||||.|||.||.||.|||:||||||||||||..||||||:||:|.:||:.||.
Zfish     1 MGLPALEFSDSFLDSPDFRERLKCHEIELDRTNKFIKELIKDGNMLISALKSLSAAVQKFSQSLQ 65

Human    66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEA 130
            :|:|:||||||||||:.||:|.:||:.:|..:|:||.|:|:||.:|||||||||||||||||||.
Zfish    66 DFQFECIGDAETDDEINIAQSFKEFSQLLNTVEEERRRLIQNADDVLITPLEKFRKEQIGAAKEG 130

Human   131 KKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFE 195
            |||:|||||||..:|||||:|||:||||.|||||:|:...||.||:.|||||||:|||||||.||
Zfish   131 KKKFDKETEKYYTVLEKHLSLSSRKKESLLQEADTQISKERQVFYDASLEYVFKIQEVQERKKFE 195

Human   196 FVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEH 260
            |||||||||||||||||.|||||.:|..:|.||..::|||||.||.||.|||:||::::....:.
Zfish   196 FVEPLLAFLQGLFTFYHEGYELAHEFEPYKQQLQFNLQNTRNNFESTRQEVENLMRRIRSAEQDF 260

Human   261 KTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKG-----GEDESVILK 320
            |....:||||:|||||||..|.:|.:|||||::.:|..||...:.|:|||.     ...|...||
Zfish   261 KAPGQWTMEGFLYVQEKRPLGCTWTRHYCTYEKGTKMFTMSNSELKTGGKQNGLIMSPPEMFKLK 325

Human   321 SCTRRKTDSIEKRFCFDVEAVD--------------------RPGVITMQALSEEDRRLWMEAMD 365
            ||.||:||||:||||||:|.|:                    |.|:||:|:|||.:|||||||||
Zfish   326 SCIRRRTDSIDKRFCFDIEVVERGNPSEGPLFSYLQCFYKAHRHGIITLQSLSESNRRLWMEAMD 390

Human   366 GREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDP 430
            |:||:|........:....|:..||:.:||||.:||.||||..|||||.||||:||:|::.:...
Zfish   391 GKEPIYTLPALLSKKEETFLNEAGFNFVRKCIESVEARGINTLGLYRIGGVNSKVQRLMTSVFAA 455

Human   431 KTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHR 495
            |..::.:.| ...|:.|||||.||.|||.|..|||.|:..:.||.|.|.::|..||..:|:||::
Zfish   456 KAPADLDLD-PDTWDNKTITSGLKNYLRCLAEPLMTYRLHKDFIMAVKSDDQNYRVCAVHALVYK 519

Human   496 LPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEIL 560
            ||:||::||.||:.||..|:.:.::|||||:||||:|||||:|.|||||||:|:|||||||:|||
Zfish   520 LPDKNKEMLNLLIKHLHVVSTHSQKNLMTVSNLGVIFGPTLMRSQEETVAAMMNIKFQNIVVEIL 584

Human   561 IENHEKIFNTVPD--MPLTNAQLH------LSRKK----SSDSKPPSCSERPLTLFHTVQSTEKQ 613
            |||::|||:..||  :||.:.|.|      ..|.|    ||.|:.......|........|....
Zfish   585 IENYDKIFHQAPDPNVPLPHPQSHSQSRGGARRSKAICLSSGSRKSRGLYPPALCLADADSDTFS 649

Human   614 EQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWP 678
            ...:|....|:||:||:.:...:.|.:..|:.|......::...|      |:||...|.||:
Zfish   650 SSPSSTPMGSMESLSSHSSEQNSCSKTGSPSRNKHKASGSLCWTT------PSPSTNGPKSPA-- 706

Human   679 MFSAPSSPMPTSSTSSD--------------SSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLL 729
            ..::|.|.....:..:|              |||...:........|....||  ||..::.||.
Zfish   707 CTTSPDSSSKEDANKTDGEWEEALSTSPGDRSSPASELLHRTLGETAEDQRSL--SSCSSLTSLH 769

Human   730 VN--FVPCHPNLHLLFDRPE----EAVH-------------EDSS-------------------- 755
            ::  |..||.::..|..|.:    :::|             :|||
Zfish   770 ISEGFRSCHGSIQSLVSRSQRDSLKSLHMPDLPPKDGMRFRDDSSASNGYQRPGSVVACRAAIFE 834

Human   756 -------TPFRKAKALYACKAEHDSELSFTAGTVFDNAECPSASTAIFTAT 799
                   |..|.|||||:|:|||..||||..|..|.|. .||.......||
Zfish   835 CPVISQPTTGRDAKALYSCQAEHSHELSFPQGAHFSNV-YPSVEPGWLQAT 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	149/205 (73%)
		BAR-PH_GRAF_family	267..371	CDD:269953	64/128 (50%)
		RhoGAP_Graf	364..563	CDD:239839	104/198 (53%)
		SH3	759..>790	CDD:473055	17/30 (57%)
arhgap42a	XP_021324560.1	BAR	19..225	CDD:472257	149/205 (73%)
		BAR-PH_GRAF_family	267..396	CDD:269953	64/128 (50%)
		RhoGAP_Graf	389..587	CDD:239839	104/198 (53%)
		Pneumo_att_G	<674..>757	CDD:114270	17/90 (19%)
		SH3_GRAF3	846..900	CDD:212999	20/40 (50%)