Protein Alignment ARHGAP26 and Graf

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_996441.2
• Gene: Graf / 32522
• FlyBaseID: FBgn0030685
• Length: 1025
• Species: Drosophila melanogaster
• Alignment Length: 989
• Identity: 334/989 - (33%)
• Similarity: 482/989 - (48%)
• Gaps: 211/989 - (21%)

Human     2 GLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNE 66
            ||..|||.:|.:|||.|||.|..||.|||.|:..||.:||:.|.|:||.|.||:..::.|..||:
  Fly    10 GLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQIKRIIKEVKDLMSAAKILSTRMKQLAILLND 74

Human    67 FKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAK 131
            |.|:|||.|:||||..|..||:.|..::.|:||||.:|:..|.:.:|..||.|||:|||..||.|
  Fly    75 FNFECIGTAQTDDENVICESLKRFGAIIGNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENK 139

Human   132 KKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEF 196
            ||:||:|||:|...|:.||:|:||.|:.:||||:.:.:..:.:.:.||.||.::||||||..|||
  Fly   140 KKFDKKTEKFCQSQERFLNMSTKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEF 204

Human   197 VEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHK 261
            ||.||||:.|...|||..:|.|:|..|:...|...:|.||..||..|.:|..|..|..|...:.:
  Fly   205 VEILLAFISGWLVFYHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPE 269

Human   262 TISPYTMEGYLYVQEK---------RHFGTSWVKHYCTYQRDSKQITMVPFDQKSGG----KGGE 313
            .|  :|..|||::.||         ..|..:|.|:|||:::..::.||:.|:|.:..    :..:
  Fly   270 EI--FTKRGYLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARD 332

Human   314 DESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVI-TMQALSEEDRRLWMEAMDGREPVYNSNKDS 377
            ||.:.|.||.||.:: .|||||||:...::|||: |.|||||:|.|.|:.||||.||.|.:....
  Fly   333 DEKLTLFSCQRRASE-FEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLAPGKI 396

Human   378 QSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICA 442
            :......||..||..||:||..:|.||:.::|:||..||.:::.|||::.::.|.:.:...|...
  Fly   397 KVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFVDDKY 461

Human   443 E--WEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQ 505
            .  .|..||.||||.|||.|..|||.||:...||:|||.|....||:|:|.||::||:.|.|||.
  Fly   462 RDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNEVHKLVYKLPQPNFQMLD 526

Human   506 LLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNT 570
            :::.||.:|:..:::|.|:|.|||||||||||||:||:||||:||||.||||.|||:|:|:||..
  Fly   527 MVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVAAILDIKFNNIVINILIDNYERIFKN 591

Human   571 VP--DMPLTNAQLHLSRKKSSDSKPPSCSER----------------------PLTL-----FHT 606
            .|  |:.|.:|....|....|.|.||:...|                      |:.|     :..
  Fly   592 KPSADIKLPDATKAPSIMYPSRSSPPTRMPRASQIGKAASTGAMGSSSNTAGNPMFLNQQKIYRV 656

Human   607 VQSTEKQEQRNSIINSSLESVSSNPNSILNSSS----------SLQPNMNSSD------------ 649
            |..|...|   ..::|||:::.:..|..|.|::          ||.|.|:..:
  Fly   657 VSKTNCTE---PTMSSSLQNIPNGDNYALGSNAMNSSGGAQCISLSPPMHMLNGILSPTIGSINN 718

Human   650 ---------------------PDLAVV-------------------------------------- 655
                                 ||..::
  Fly   719 LHTISKNETSTRRYVPDTEIAPDYGIIGANNGGVTLQSHHAVPVSSTSNFRHPEYLMTTANPVTQ 783

Human   656 --------------------KPTRPNSLPPNPSPTSPL---SPSWPMFSAP-------------- 683
                                :.:..|..|||.:.....   |.|.|....|
  Fly   784 SGSSSHIYTNTSSAGANSSNRISLSNVSPPNTAMRKERFLGSASGPQQHPPVQRGLHSYGQTKHY 848

Human   684 SSPMPTSSTSSDSSPVRSVAGFVWFSVAAVV-----------LSLARSSLHAVFS---------- 727
            |..||||::||:.|...|::.......:.|.           ||...::.:|:.|
  Fly   849 SPLMPTSTSSSNDSVCDSLSSNNGLGSSIVANSGNSGNVAQHLSARNTNDYALISSQNSSLSPHL 913

Human   728 -------LLVNFVP-----C---------HPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEH 771
                   :....:|     |         :|...:..:|....:..|.||...:.:.||||..|.
  Fly   914 GPTCDEVVTATTLPSVSLSCGGTASESTEYPPSKMHRNRDVNQIKRDLSTGTARVRTLYACMGES 978

Human   772 DSELSFTAGTVFDN 785
            :.||||....:..|
  Fly   979 EGELSFEPNQIITN 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	102/205 (50%)
		BAR-PH_GRAF_family	267..371	CDD:269953	48/117 (41%)
		RhoGAP_Graf	364..563	CDD:239839	97/200 (49%)
		SH3	759..>790	CDD:473055	10/27 (37%)
Graf	NP_996441.2	BAR_RhoGAP_OPHN1-like	27..233	CDD:153286	102/205 (50%)
		BAR-PH_GRAF_family	273..390	CDD:269953	48/117 (41%)
		RhoGAP	383..584	CDD:470621	97/200 (49%)
		SH3_GRAF-like	967..1020	CDD:212815	10/26 (38%)