Protein Alignment ARHGAP26 and cnt6

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_594153.1
• Gene: cnt6 / 2542074
• PomBaseID: SPAC26A3.10
• Length: 923
• Species: Schizosaccharomyces pombe
• Alignment Length: 745
• Identity: 137/745 - (18%)
• Similarity: 259/745 - (34%)
• Gaps: 229/745 - (30%)

Human    14 DSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETD 78
            |.|.||..|...|.:......:.|:::|....|..|......|..|.:::|:|.......:.:..
pombe   230 DGPSFRSMLHELEQKSSLMKYYCKKIMKRIVQLSDAYDASQVAVMKLSETLSEASNSTSMNMDIL 294

Human    79 DEMCIARSLQEFATVLRNLEDERIRMI----ENASEVLITPLEKFRKEQIGAAKEAKKKYDKETE 139
            .:..:.:::...||.::.|..:.|.::    .|.....|.|::..|.|           :|::::
pombe   295 LDSYLTKAMDIHATFIQKLNYDLINLLYEPFHNIYSSFIKPIDDRRLE-----------FDEQSK 348

Human   140 KYCGILEKHLNLSSKKK--ESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLA 202
            .:.|.|.::|:....||  :|:..:.:....|.|..:      |.| :|::.:..:...:..:
pombe   349 SFYGSLSRYLSAKKDKKGGDSKFFQKEKTFALQRYDY------YCF-MQDLHDGSIINDINGI-- 404

Human   203 FLQGLFTFYHHGYELAKDFGDFKT-------QLTISIQNTR----NRFEGT---RSEVESLMKKM 253
            |||    ::|..|:....|.:...       ||.:.::.|:    .|.:|.   ||:|.....:.
pombe   405 FLQ----YFHRQYDHIALFSNLMNSVLPNLQQLNLKLEKTKWSTTRRDKGREMHRSQVIQTSGRP 465

Human   254 KE------NPLE-----HKTISP------------------YT--------------------ME 269
            |.      :|:.     |:..||                  :|                    .|
pombe   466 KSMAPPSPSPISPSFPLHEIQSPMPNRRMAASADDISQTSNFTTEIKGKCISNGGSASPDKIFKE 530

Human   270 GYLYVQEKRHFGT--------SWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRK 326
            |.|.|......||        :|.||:...:..|    :..:............|:.||..:..|
pombe   531 GLLLVFGATELGTDLAMVSKAAWHKHWIVVENGS----LWEYANWKDSVKSNVSSISLKHASADK 591

Human   327 TDSIEKRFCFDVEAVDRPGVIT------MQALSEEDRRLWMEAMDGRE----------------- 368
            .....:||||:        |:|      .||.|.|:...|:||:....
pombe   592 VRKQGRRFCFE--------VVTPKLKRLYQATSAEEMDSWIEAICEAAKISSFQLSRVATPLSAS 648

Human   369 --------PVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGI-NEQGLYRIVGVNS------ 418
                    |:::::    .|.|.....:..|.|:|   |...:|. |.|..:|  ..||
pombe   649 VRRPSKVFPLFSTS----FETTPISRKLSGSGIKK---AFSRKGSWNLQQFFR--SDNSGTMHME 704

Human   419 ---RVQKLLSVLMDPKTASETETDICAE--------W-----------EIKTITSALKTYLRMLP 461
               |.....::.:.....::....:||:        |           |...|..:|.|::....
pombe   705 QLERYHASANIFIQMLRKTDVSNSVCADCGSVKDVTWCSINIPVVLCIECSGIHRSLGTHISKTR 769

Human   462 GPLMMYQFQRSFIKAAKLENQESRVSEIH-------SLVHRLPEKNRQM-----LQLLMNHL--- 511
            ..|:....|:|.:...|:.|  :.|:.::       ||..: ||.|.|:     .:..:.|.
pombe   770 SLLLDSLSQQSKVLLCKIGN--AAVNRVYEKGLSNPSLKPK-PEHNAQVKLAFAQKKYVEHAFID 831

Human   512 -------ANVANNHKQNLMTVANL-----------GVVFGPTLLRPQEETVAAIMDIKFQNIVIE 558
                   |.:....:||.::...|           ||||...:.|  :.:...::::.|.|   .
pombe   832 FAGVDADATLLEGLEQNKISKILLGLAAKPNFEENGVVFLKAVTR--DTSKLHLLELLFMN---G 891

Human   559 ILIENHEKIFNTV-PDMPLTNAQLHLSRKK 587
            :|:.:.|::...| |||     |.:||:|:
pombe   892 LLLPDSEQLSEHVSPDM-----QSYLSQKQ 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	38/211 (18%)
		BAR-PH_GRAF_family	267..371	CDD:269953	29/162 (18%)
		RhoGAP_Graf	364..563	CDD:239839	46/285 (16%)
		SH3	759..>790	CDD:473055
cnt6	NP_594153.1	BAR_ArfGAP_fungi	236..430	CDD:153292	37/217 (17%)
		PH	527..632	CDD:214574	27/116 (23%)
		COG5347	714..>923	CDD:227651	41/216 (19%)