Protein Alignment ARHGAP26 and rga4

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_595756.1
• Gene: rga4 / 2540593
• PomBaseID: SPBC28E12.03
• Length: 933
• Species: Schizosaccharomyces pombe
• Alignment Length: 688
• Identity: 154/688 - (22%)
• Similarity: 267/688 - (38%)
• Gaps: 185/688 - (26%)

Human     3 LPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLIS------ALKNLSS------ 55
            ||.|..::..::.|..|.:...:...:..|....|.....|:..:|      ||:::::
pombe   308 LPQLPKNESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKV 372

Human    56 -AKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERI--------RMIENASEV 111
             ..|....:|:|:   .:...|:|:....|| ...:.||...|:|:|:        :.:.|:|..
pombe   373 PRNRNSLSNLDEY---YVNGLESDETPTKAR-FPRYPTVFNKLDDKRLSSEPNGLKKRLTNSSNY 433

Human   112 LITPLEK-FRKEQIGAAKEAKKKYDKE---------TEKYCGILEKHLN-LSSKKKESQ------ 159
            ..:|..| ....|:...:..:.:|::.         |.......|:..| |:.:..|.|
pombe   434 EASPRAKSLNLSQVSLHQACEPEYNRSSLVRASDVFTSNVFDATEESANELAIRISELQAEVGTL 498

Human   160 LQEADSQVDLVRQHFYEVSLEYVFKVQEVQE--------RKMFEFVEPLLAFLQGLFTFYHHGYE 216
            |.||.|...::.|. ..||.| .||.:.|.:        ||.|   :|.|:.|.
pombe   499 LLEATSLASIIEQQ-TPVSPE-AFKQELVADLNYRLDYLRKSF---QPELSTLL----------- 547

Human   217 LAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKE-----NPLEHKTISPYTMEGYLYVQE 276
            |.:|      .|:.::...:|.:.....|...|..|..|     |.||.:         ..|::|
pombe   548 LRRD------ALSTTVSKLQNAYSTVMEETAYLNVKNTELVSLNNQLERE---------LAYLRE 597

Human   277 KRH-------FGTSWVKHYCTYQRDSK---------------QITMV-------PFDQK---SGG 309
            ::|       ||        .:..|.|               ::.||       |.|.|   |||
pombe   598 QQHKKRTSSSFG--------IFNNDKKSNRTISTPSPRESFSRLQMVASSLGFRPKDNKDKESGG 654

Human   310 KGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEE------------------- 355
            ....:..:.||.       |..|||.:   ..|.|.:.:..::|||
pombe   655 YNKRNSKIDLKK-------SFSKRFHW---KRDSPHMSSTPSISEEHLASEEQEDFVPAVGHCKL 709

Human   356 --------------------DRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400
                                ||:  .::.....||:..|.|...:....|..:. ::|..||:.:
pombe   710 CGKYSNELRAHYQDCVSSTIDRQ--YQSKKSESPVWALNPDDFDQNRLTLLRVP-TLIVSCINFI 771

Human   401 ETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLM 465
            |:.|::.:||||..|..|:::|::::|.:..|..:...||.|      :||..|.|||.||.|::
pombe   772 ESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDPSEDISA------VTSVFKQYLRNLPNPII 830

Human   466 MYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGV 530
            .|.....||.||...:.:.::.....::..||..:.::|||::.|||.||.....|.||..||.|
pombe   831 TYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAV 895

Human   531 VFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIF 568
            ||.|||:|..:.: ..::|:..:|..:..||::..::|
pombe   896 VFSPTLIRDPDNS-RDVIDMTVKNYSLAFLIDHVHEVF 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	50/251 (20%)
		BAR-PH_GRAF_family	267..371	CDD:269953	29/174 (17%)
		RhoGAP_Graf	364..563	CDD:239839	62/198 (31%)
		SH3	759..>790	CDD:473055
rga4	NP_595756.1	LIM	24..78	CDD:259829
		CENP-H	543..>606	CDD:461756	16/88 (18%)
		RhoGAP	759..928	CDD:214618	57/176 (32%)