Protein Alignment ARHGAP26 and T04C9.1

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: NP_741163.2
• Gene: T04C9.1 / 175849
• WormBaseID: WBGene00020209
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 885
• Identity: 310/885 - (35%)
• Similarity: 459/885 - (51%)
• Gaps: 134/885 - (15%)

Human     1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
            |.|.||||||...|||.||:.|..||..||...|.||.:....|.||:..|.||:|:|.||.:|:
 Worm     1 MVLRALEFSDSISDSPWFRQNLHDHEVALDDAFKNIKLIENQCKELIACTKKLSTAQRAFAKTLS 65

Human    66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIG-AAKE 129
            ||||:.:|..:||||..||..|:||.:::..:||||::::..|.|..:.|::|||.|.|| ..||
 Worm    66 EFKFETVGTNQTDDERFIATCLKEFGSLINQVEDERMKLVGQAEESYLEPIKKFRTEAIGRTLKE 130

Human   130 AKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMF 194
            .|.|||||:.|:...|||||:||: .:.:..:.||:|::..:::|::.||:||.:||.||||..|
 Worm   131 EKNKYDKESSKFYQTLEKHLHLST-VRNNDFRAADAQLETQQKNFFQASLQYVAEVQSVQERMRF 194

Human   195 EFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPL- 258
            ||||.|.:::....:|:|.|..:.:||..|...:...:|.|:..:..|.:|.|.|.||:..:..
 Worm   195 EFVETLGSYVYSWLSFFHVGSVIHQDFKPFLDNVQTKVQKTKENYNATNAEAEELKKKLLASHTK 259

Human   259 ---EHKTISPYTMEGYLYVQEKRHFGTS---------WVKHYCTYQRDSKQITMV------PFDQ 305
               |.:..:|...:||:|:|||.....:         |.|:||.|.|:::..|||      ..|.
 Worm   260 PGSEDRRPTPSIKQGYVYMQEKSKIPKTIGRDVLLGRWTKYYCVYSRETRIFTMVSANSATKTDM 324

Human   306 KSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDG-REP 369
            ||.  ..:..:...|||:||..|||:|||||||...::..|:|||||||:|...|::|||| ::.
 Worm   325 KSA--VAQTATFKFKSCSRRPMDSIDKRFCFDVCVEEKNDVMTMQALSEKDLCEWIDAMDGAKQN 387

Human   370 VYNS--NKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKT 432
            .|.:  |....:....|||.|||..:::||..:|..||:|||:||..||.|:|||::.:.:|.:.
 Worm   388 SYTAGENPSCSTYKQTQLDDIGFEFVQQCIDILEESGIHEQGVYRNCGVTSKVQKMMMLGLDRRK 452

Human   433 ASE-----TETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSL 492
            |||     ...|   |||.|||:||:||:||.||.|||.::....||.|||:.:...|:..||..
 Worm   453 ASEKGGLNLRDD---EWETKTISSAVKTFLRNLPEPLMTFELHNVFINAAKMGDATMRIDHIHFY 514

Human   493 VHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVI 557
            ||:||.::.:||::::.||..||:...:|||||:||||.||||||||:||||||||||||.|:|:
 Worm   515 VHQLPAQHLRMLEIVVRHLKRVADLSNENLMTVSNLGVCFGPTLLRPKEETVAAIMDIKFCNVVV 579

Human   558 EILIENHEKIFNTVP--------------------DMPLTNAQLHLS-----RKKSSDSKPPSCS 597
            |:||.|::|||.:.|                    ..||.......|     ..:|...|.|...
 Worm   580 EVLISNYDKIFKSKPKSSFGSAVPPKPDHHTSYDNGRPLATRSFGTSTPSPITSRSRSPKTPGVG 644

Human   598 ERPLTLFHTVQSTEKQ--EQRNSIINSSL-------------ESVSSNPNSILNSSSSLQPNMNS 647
            .:.:.....|.|:..:  ::|:::..|.:             :....|..|.|.|.:.:.|..:.
 Worm   645 SKIVRSTQVVSSSYSRGMQKRDAMYPSEIARHGIGFDVGELGDFQIENNRSPLTSPTGIAPLASG 709

Human   648 SDPDLAVVKPTRPNS----------------------LPPNPSPTSPLSPSWPM-FSAPSSPMPT 689
            |..::..|.....||                      ..|:....|.:.|.:.: :::..:.:|.
 Worm   710 SIEEIDEVAKKERNSSDSLNSLGSFGSVGDESTATVVAAPDGFGKSIVKPKYSVSYASTYNRIPA 774

Human   690 SS---TSSDSSPVRSVAGFVWFSVAAVVL------SLARSSLHAVFSLLVNFVPCHPNLHLLFDR 745
            .|   |||.|.......|.|..|..::..      :|..||:...:..|
 Worm   775 DSSKLTSSISCTTVDSTGVVETSFTSLTRQNYLRGTLDSSSMGTTYKYL---------------- 823

Human   746 PEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDN 785
                        .|:.|.||||..:|.|||||..|.:..|
 Worm   824 ------------SRRVKTLYACTPDHHSELSFEPGQIITN 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	88/206 (43%)
		BAR-PH_GRAF_family	267..371	CDD:269953	47/119 (39%)
		RhoGAP_Graf	364..563	CDD:239839	101/206 (49%)
		SH3	759..>790	CDD:473055	14/27 (52%)
T04C9.1	NP_741163.2	BAR_RhoGAP_OPHN1-like	19..225	CDD:153286	88/206 (43%)
		BAR-PH_GRAF_family	271..388	CDD:269953	47/118 (40%)
		RhoGAP	381..585	CDD:470621	101/206 (49%)
		SH3_GRAF-like	826..879	CDD:212815	13/26 (50%)