Protein Alignment ARHGAP26 and arhgap26

DIOPT Version :10

• Sequence 1: XP_047272926.1
• Gene: ARHGAP26 / 23092
• HGNCID: 17073
• Length: 816
• Species: Homo sapiens
• Sequence 2: XP_012814023.2
• Gene: arhgap26 / 100145296
• XenbaseID: XB-GENE-1011980
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 801
• Identity: 617/801 - (77%)
• Similarity: 668/801 - (83%)
• Gaps: 75/801 - (9%)

Human     1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
            ||||.||||||.||||.|||.|||||.|||||||||||||||||||::|.||||.||||||.|||
 Frog     1 MGLPPLEFSDCYLDSPQFRERLKSHEIELDKTNKFIKELIKDGKSLVAAHKNLSCAKRKFAGSLN 65

Human    66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEA 130
            ||||:||||||||||:||||||||||.||.||||||||||:|:.||||:|||||||||:|||||.
 Frog    66 EFKFRCIGDAETDDEICIARSLQEFAAVLGNLEDERIRMIDNSGEVLISPLEKFRKEQVGAAKEV 130

Human   131 KKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFE 195
            |||||||:||||.:||||:||||||||..|.|||.|:|.:||||||||||||.||.|||||||||
 Frog   131 KKKYDKESEKYCAMLEKHMNLSSKKKEVLLHEADVQLDQMRQHFYEVSLEYVLKVHEVQERKMFE 195

Human   196 FVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEH 260
            ||||||||||||||||||||||||||.||||||:|||||||:||||||||||||||||||||.||
 Frog   196 FVEPLLAFLQGLFTFYHHGYELAKDFSDFKTQLSISIQNTRDRFEGTRSEVESLMKKMKENPHEH 260

Human   261 KTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRR 325
            ..:||||||||||||||||||||||||||||||::||:||||||||||||.||:|.:.||||.||
 Frog   261 LALSPYTMEGYLYVQEKRHFGTSWVKHYCTYQRETKQMTMVPFDQKSGGKVGEEEIIHLKSCIRR 325

Human   326 KTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGF 390
            ||:|||||||||||.||||.|:||||||||||:||||||||||||||||||||||||||||:|||
 Frog   326 KTESIEKRFCFDVEGVDRPTVLTMQALSEEDRKLWMEAMDGREPVYNSNKDSQSEGTAQLDNIGF 390

Human   391 SIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKT 455
            |||||||.||||||||||||||||||||||||||:.|||||.:.||||:|.:|||||||||:|||
 Frog   391 SIIRKCIQAVETRGINEQGLYRIVGVNSRVQKLLNFLMDPKISPETETEIPSEWEIKTITSSLKT 455

Human   456 YLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQ 520
            ||||||||||.|||||||||||||||||||:.|||.|:|||||||||||.|||.||||||.:|||
 Frog   456 YLRMLPGPLMTYQFQRSFIKAAKLENQESRIKEIHCLIHRLPEKNRQMLNLLMTHLANVAAHHKQ 520

Human   521 NLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSR 585
            |||||||||:||||||||||||||||||||||||||:||:|||:||:|:|||:||.||:||||||
 Frog   521 NLMTVANLGIVFGPTLLRPQEETVAAIMDIKFQNIVVEIIIENYEKMFSTVPEMPQTNSQLHLSR 585

Human   586 KKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESV-SSNPNSILNSS---SSLQPNMN 646
            |:|||||||||||||||||||..||||:|:||| :|||.||| |||.||..||:   .|...|:|
 Frog   586 KRSSDSKPPSCSERPLTLFHTTHSTEKEEKRNS-VNSSAESVSSSNANSSANSTCTQCSNMNNLN 649

Human   647 SSDPDLAVVKPTRPNS----------LPP--NPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPV 699
            :|||||.|.|.:||||          ||.  |||||||  |:.||||||||||||||||||||||
 Frog   650 ASDPDLDVAKASRPNSLLNPKNISGLLPSSLNPSPTSP--PTCPMFSAPSSPMPTSSTSSDSSPV 712

Human   700 RSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKAL 764
                                                                   |.| ||||||
 Frog   713 -------------------------------------------------------SVP-RKAKAL 721

Human   765 YACKAEHDSELSFTAGTVFDN 785
            |||||||||||||:|||||||
 Frog   722 YACKAEHDSELSFSAGTVFDN 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP26	XP_047272926.1	BAR_GRAF	19..225	CDD:153320	174/205 (85%)
		BAR-PH_GRAF_family	267..371	CDD:269953	89/103 (86%)
		RhoGAP_Graf	364..563	CDD:239839	175/198 (88%)
		SH3	759..>790	CDD:473055	26/27 (96%)
arhgap26	XP_012814023.2	BAR_GRAF	19..225	CDD:153320	174/205 (85%)
		BAR-PH_GRAF_family	267..371	CDD:269953	89/103 (86%)
		RhoGAP_Graf	364..563	CDD:239839	175/198 (88%)
		SH3_GRAF	716..771	CDD:212997	26/27 (96%)